1 palmitoyl 2 oleoyl sn glycero 3 phosphocholine

1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1, 2- dioleoyl-sn-glycero-3-phosphocholine (DOPC) were purchased from the NOF Corporation (Tokyo, Japan). 1,2-dioleoyl-sn-glycero-3-phsphoEthanolamine-N-(lissamine rhodamine B sulfonyl) (Rho-PE) was purchased from Avanti Polar Lipids, Inc. (810150C, Alabaster, AL, USA). Ethanol, sodium chloride, and chloroform were purchased from Wako Pure Chemical Industries, Ltd. (Osaka, Japan).

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 1,2-dioleoyl-sn-glycero-3-phosphoEthanolamine (DOPE), 1,2-dioleoyl-3-dimethylammonium-propane (DODAP), and 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (DMG-PEG2K) were purchased from the NOF Corporation (Tokyo, Japan). Cholesterol was purchased from Sigma-Aldrich (St. Louis, MO, USA). A pH-sensitive cationic lipid, CL4H6, was synthesized in the laboratory as previously described.^{19 (link)} Ethanol, sodium chloride, citric acid, 2-morpholinoethanesulfonic acid (MES), monohydrate, and phosphate-buffered saline (PBS) were purchased from FUJIFILM Wako Pure Chemical Corporation (Osaka, Japan). The siFVII and Cy-5-labeled siGL4 were purchased from Hokkaido System Science Co. Ltd. (Sapporo, Japan). Table S4† shows the sense and antisense strand sequences of siFVII and Cy5-siGL4. Quant-iT™ Ribogreen™ RNA reagent and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI) were obtained from Thermo Fisher Scientific (Waltman, MA, USA). SU-8 3050 was obtained from Nippon Kayaku Co., Ltd. (Tokyo, Japan).