All participants were scanned on the same 3.0-T MRI, Magnetom Skyra (Siemens Healthineers, Erlangen, Germany), within 1 month after diagnosis. The anatomical sequence was a sagittal Three-dimensional (3D) T1-weighted magnetization-prepared rapid gradient-echo, MPRAGE. The DCE sequence was a 3D T1-weighted volumetric interpolated breath-hold examination, VIBE, spoiled gradient echo with 80 frames and temporal resolution 7.2 s. Contrast agent was injected intravenously after 10 frames (Dotarem, Guerbet, Villepinte, France) 0.2 mL/kg, 0.5 mmol/mL, at the rate of 2 mL/s, followed by 20 mL of saline solution (power injector, MedRad Spectris Solaris EP, Bayer, Leverkusen, Germany). Precontrast T1 mapping was done with a dual flip angle 3D spoiled gradient-echo sequence with geometry identical to that of the DCE sequence. Detailed scan parameters are presented in Supplemental Table S1 .
Medrad spectris solaris ep
Manufactured by Bayer
Sourced in Germany
The Medrad Spectris Solaris EP is a piece of lab equipment designed for medical imaging. It is primarily used in the administration and monitoring of contrast media during diagnostic imaging procedures.
Automatically generated - may contain errors
4 protocols using medrad spectris solaris ep
1
MRI Imaging Protocol for Diagnostic Evaluation
2
In Vivo Ciprofloxacin Biodistribution
3
Gadolinium-Enhanced 3D Nerve Imaging Protocol
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Each subject underwent routine MRI pre-examination preparation, which included weight measurement and the placement of intravenous indwelling needles. All examinations were conducted using a Philips Ingenia 3.0T MRI scanner (Philips Healthcare). Patients were asked to empty their bladder and bowel prior to MR examination. The subjects were positioned in a supine position with their hands raised above their heads. To obtain a high signal-to-noise ratio, a 32-channel abdominal coil (anterior coil) was utilized to cover the pelvis. The coil was positioned parallel to the coronal plane of the body and the scanning bed. Before and after gadolinium contrast administration, 3D NerveVIEW scans were performed. The contrast was injected by power injector (Medrad Spectris Solaris EP, Bayer Healthcare) at a flow rate of 2.0 mL/s and a dosage of 0.2 mmol/kg, followed by rinsing with 20 mL of physiological saline at the same injection rate.
4
Quantitative Multimodal Neuroimaging Protocol
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All images were acquired using computed tomography (CT) and MR simulations. During CT simulation, the patient was supine, with their head fixed with a thermoplastic film, and a Philips Brilliance Big Bore CT positioning machine (Philips Healthcare, Best, Netherlands) was used to scan with a 3-mm layer thickness and 3-mm layer spacing. Following CT simulation, the patients were placed in the same position and fixed mode using a 6-channel flex coil in GE 3.0 T MR scanner (Discovery 750 W; GE Healthcare, Chicago, IL, USA), and T1 plain scan and multi-phase enhanced 3D T1-weighted gradient-echo brain volume images (T1 BRAVO) at 1, 3, 5, 10, 18, and 20 min were obtained after intravenous injection of gadolinium-containing contrast medium.
The scan parameters were set as follows: TR = 8.5 ms, TE = 3.2 ms, matrix = 256 × 256, FOV = 256 mm × 256 mm, slice thickness = 1 mm, and slice number = 50–52; the T1 acquisition time of one phase was limited to between 1 min 55 s and 1 min 58 s. Gadoteric acid meglumine salt was injected with a binocular high-pressure syringe system (MEDRAD® Spectris Solaris EP, Bayer, Leverkusen, Germany) at a rate of 2 mL/s and dose of 0.2 mL/kg and flushed with 20 mL saline.
The scan parameters were set as follows: TR = 8.5 ms, TE = 3.2 ms, matrix = 256 × 256, FOV = 256 mm × 256 mm, slice thickness = 1 mm, and slice number = 50–52; the T1 acquisition time of one phase was limited to between 1 min 55 s and 1 min 58 s. Gadoteric acid meglumine salt was injected with a binocular high-pressure syringe system (MEDRAD® Spectris Solaris EP, Bayer, Leverkusen, Germany) at a rate of 2 mL/s and dose of 0.2 mL/kg and flushed with 20 mL saline.
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