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Pazopanib

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Pazopanib is a small molecule kinase inhibitor developed by Santa Cruz Biotechnology. It primarily targets vascular endothelial growth factor receptors (VEGFR) and platelet-derived growth factor receptors (PDGFR). Pazopanib is used as a research tool to investigate angiogenesis and tumor growth pathways.

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Lab products found in correlation

Su5416, by Merck Group (2 mentions) Metronidazole, by Merck Group (2 mentions) Sunitinib, by Merck Group (1 mentions) Vinblastine, by Merck Group (1 mentions) Cyclopamine, by Merck Group (1 mentions) Ribavirin, by Merck Group (1 mentions) Dasatinib, by Merck Group (1 mentions) Docetaxel, by Merck Group (1 mentions) Akti 1 2, by Selleck Chemicals (1 mentions) Abt 737, by Santa Cruz Biotechnology (1 mentions) Bicalutamide, by Merck Group (1 mentions) Salinomycin, by Merck Group (1 mentions) 4egi 1, by Santa Cruz Biotechnology (1 mentions) Amg102, by Amgen (1 mentions) As 252424, by Cayman Chemical (1 mentions) Cgp 57380, by Cayman Chemical (1 mentions) Tamoxifen, by Merck Group (1 mentions) Doxorubicin, by Merck Group (1 mentions) Pd98059, by Merck Group (1 mentions) Su11274, by Merck Group (1 mentions)

3 protocols using pazopanib

1

Zebrafish Drug Treatment Protocol

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Metronidazole (M1547; Sigma-Aldrich; final concentration 5 mM) was dissolved in water, the relatively high concentration of Metronidazole seems to be a function of bioavailability in zebrafish as higher concentrations are routinely required for nitroreductase mediated cellular ablation studies38 (link). Pazopanib (sc-364564; Santa Cruz Biotechnology; final concentration 250 nM for larvae, 1 μM for adults) and SU5416 (S8442; Sigma-Aldrich; final concentration 250 nM) were dissolved in DMSO. Metronidazole, Pazopanib, SU5416 were added immediately after infection and refreshed every two days for the duration of the experiment. Randomisation into drug treatment groups was achieved by random selection of infected zebrafish from a single pool prior to addition of drugs.
Oehlers S.H., Cronan M.R., Scott N.R., Thomas M.I., Okuda K.S., Walton E.M., Beerman R.W., Crosier P.S, & Tobin D.M. (2014). Interception of host angiogenic signalling limits mycobacterial growth. Nature, 517(7536), 612-615.
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2

Comprehensive Pharmacological Screening Protocol

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The following 43 reagents were used in this study: AMG 102 and panitumumab (Amgen); cercosporamide (BioAustralis); AKT inhibitor V (Calbiochem); AS-252424, bisindolylmaleimide, CGP 57380 and imatinib (Cayman Chemical); CTX ILK inhibitor (CRC); Avastin (bevacizumab) (Genentech/Roche); 4EGI-1, ABT-737, ABT-737 enantiomer, pazopanib, and retinoic acid (Santa Cruz Biotechnology); erlotinib, lapatinib, sorafenib, and temsirolimus (Scientifix); bortezomib and CYT387 (Selleck Chemicals); AKT-I-1/2, axitinib, bicalutamide, cilostazol, cyclopamine, DAPT, dasatinib, docetaxel, doxorubicin, floxuridine, fluorouracil, goserelin, ifosfamide, PD98059, ribavirin, salinomycin, SU11274, sunitinib, Tamoxifen, and vinblastine (Sigma); NSC 7908 (Tocris); and temozolomide (Wyeth).
Kerr L.T., Donoghue J.F., Wilding A.L, & Johns T.G. (2016). Axitinib Has Antiangiogenic and Antitumorigenic Activity in Myxoid Liposarcoma. Sarcoma, 2016, 3484673.
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3

Zebrafish Drug Treatment Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols
Metronidazole (M1547; Sigma-Aldrich; final concentration 5 mM) was dissolved in water, the relatively high concentration of Metronidazole seems to be a function of bioavailability in zebrafish as higher concentrations are routinely required for nitroreductase mediated cellular ablation studies38 (link). Pazopanib (sc-364564; Santa Cruz Biotechnology; final concentration 250 nM for larvae, 1 μM for adults) and SU5416 (S8442; Sigma-Aldrich; final concentration 250 nM) were dissolved in DMSO. Metronidazole, Pazopanib, SU5416 were added immediately after infection and refreshed every two days for the duration of the experiment. Randomisation into drug treatment groups was achieved by random selection of infected zebrafish from a single pool prior to addition of drugs.
Oehlers S.H., Cronan M.R., Scott N.R., Thomas M.I., Okuda K.S., Walton E.M., Beerman R.W., Crosier P.S, & Tobin D.M. (2014). Interception of host angiogenic signalling limits mycobacterial growth. Nature, 517(7536), 612-615.
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