Kaempferol

Manufactured by Selleck Chemicals

Sourced in China

Kaempferol is a chemical compound that functions as a flavonoid. It is a naturally occurring substance found in various plants. Kaempferol serves as a core component in laboratory research and analysis processes.

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Lab products found in correlation

3 protocols using kaempferol

Kaempferol Rescues Premature Ovarian Failure

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Female 129S1 Sirt3^+/+ or Sirt3^−/− mice with successful premature ovarian failure modeling received further Kaempferol treatment. Kaempferol (SELLECK, S2314) was dissolved in DMSO to prepare a stock solution of 50 mg/mL, and then it was diluted with normal saline so that the DMSO concentration was 0.72% v/v, while the Kaempferol concentration was 0.36 mg/mL. The Kaempferol-treated mice were injected with Kaempferol (10 mg/kg, i.p.) from day 46 for 14 days, while the control mice were injected with an equal volume of 0.72% v/v DMSO/NS solution at the same time. After the end of the Kaempferol treatment (day 60 from VCD modeling starting), the behavioral tests were performed, and then, the hippocampus/ovary/blood were collected. The procedure of study was exhibited in Figure 2A and Table S1.

Li H.Y., Wang J., Liang L.F., Shen S.Y., Li W., Chen X.R., Li B., Zhang Y.Q, & Yu J. (2022). Sirtuin 3 Plays a Critical Role in the Antidepressant- and Anxiolytic-like Effects of Kaempferol. Antioxidants, 11(10), 1886.

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Kaempferol Regulates IQGAP3 Expression

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ZR-75-30 and BT474 cells were respectively divided into groups infected with the lentiviruses of IQGAP3 overexpression (IQGAP3) and negative control (Vector), respectively, with RPMI-1640 medium-treated cells as control. After 48 h of transfection, the expression of IQGAP3 in ZR-75-30 and BT474 cells was detected by real-time PCR and Western blot analysis.
To further investigate the interaction between Kaempferol and IQGAP3, as well as the potential underlying mechanism, ZR-75-30 and BT474 cells were divided into groups treated with Vector+DMSO, IQGAP3+DMSO, 20 μM PD98059 (ERK inhibitor, Selleck, S1177; solvent: DMSO), Vector+25 μmol/l Kaempferol (Source Leaf Biotechnology Co., B21126, Shanghai, China; solvent: DMSO), IQGAP3+25 μmol/l Kaempferol, Vector+25 μmol/l Kaempferol+100 ng/ml EGF (R&D, 236-EG, USA; solvent: PBS), or IQGAP3+25 μmol/l Kaempferol+100 ng/ml EGF. Cell apoptosis and Western blot assays were performed after 48 h of treatment.

Hu G., Liu H., Wang M, & Peng W. (2019). IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 25, 7666-7674.

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Dietary Compounds from Selleckchem in Research

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The following dietary compounds were purchased from Selleckchem: apigenin (Selleckchem, Cat#- S2262), baicalein (Selleckchem, Cat#- S2269), baicalin (Selleckchem, Cat#- S2268), berberine hydrochloride (Selleckchem, Cat#- S2271), Cat#- S2268), caffeic acid (Selleckchem, Cat#- S2277), dihydromyricetin (Selleckchem, Cat#- S2399), emodin (Selleckchem, Cat#- S2295), (−)-epigallacatechin gallate (Selleckchem, Cat#- 2250), gossypol acetate (Selleckchem, Cat#- S2303), hematoxylin (Selleckchem, Cat#- S2384), indirubin (Selleckchem, Cat#- S2386), kaempferol (Selleckchem, Cat#- S2314), luteolin (Selleckchem, Cat#- S2320), morin hydrate (Selleckchem, Cat#- S2325), myricetin (Selleckchem, Cat#- S2326), myricitrin (Selleckchem, Cat#- S2327), palmatine chloride (Selleckchem, Cat#- S2397) and quercetin dihydrate (Selleckchem, Cat#- S2347).

Evans L., Shen Y., Bender A., Burnett L.E., Li M., Habibian J.S., Zhou T, & Ferguson B.S. (2021). Divergent and Overlapping Roles for Selected Phytochemicals in the Regulation of Pathological Cardiac Hypertrophy. Molecules, 26(5), 1210.

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