Lysophosphatidylserine

Manufactured by Avanti Polar Lipids

Sourced in United States

Lysophosphatidylserine is a phospholipid compound produced by Avanti Polar Lipids. It is a precursor molecule used in various biochemical and biophysical applications.

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3 protocols using lysophosphatidylserine

Lipid Standards for Lipidomic Analysis

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The following lipids were purchased from Avanti Polar Lipids: dioleoyl-phosphatidic acid, dioleoyl-phosphatidylcholine, dioleoyl-phosphatidylethanolamine, phosphatidylglycerol (PG), dioleoyl-phosphatidylinositol, and dioleoyl-phosphatidylserine and the corresponding lysophospholipids monooleoyl(sn-1)-lysophosphatidic acid, -lysophosphatidylcholine, -lysophosphatidylethanolamine, -lysophosphatidylglycerol, -lysophosphatidylinositol, and -lysophosphatidylserine; dioctanoyl-phosphatidylcholine and dioctanoyl-PG; bis-dioleoyl cardiolipin; bis(dioleoylglycero)phosphate; N-acylphosphatidylethanolamine; plasmanylcholine; sn-3,3′-oleoyl-BMP(S,S and R,R); 1-oleoyl-N-heptadecanoyl-d-erythro-sphingosine; and 1,2-diacyl-3-O-β-d-galactosyl-sn-glycerol. The following lipids were purchased from Sigma-Aldrich: dioleoylglycerol, trioleoylglycerol, glyceryl trioctanoate, monoolein, retinyl palmitate, arachidyl laurate, cholesteryloleate, and oleoyl-carmitin. Methylpalmitate, ethylpalmitate, propylpalmitate, and butylpalmitate as well as sn-2,2′-oleoyl-BMP(S,S) were synthesized according to published procedures (20 , 21 (link)). Labeled BMP was synthesized using oleic acid ¹³C₁₈ (Sigma-Aldrich) according to Refs. 21 (link).

Pribasnig M.A., Mrak I., Grabner G.F., Taschler U., Knittelfelder O., Scherz B., Eichmann T.O., Heier C., Grumet L., Kowaliuk J., Romauch M., Holler S., Anderl F., Wolinski H., Lass A., Breinbauer R., Marsche G., Brown J.M, & Zimmermann R. (2015). α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate. The Journal of Biological Chemistry, 290(50), 29869-29881.

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Lysophospholipid Profiling in Mouse RBCs

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Lysophospholipids in fresh and stored RBCs from FVB mice were analyzed by liquid chromatography–tandem mass spectrometry (LC–MS/MS) as described previously.^{29 (link)} Briefly, analytes were extracted by 80% methanol (vol/vol) with an internal standard mixture containing lyso-platelet-activating factor C-16-d4 (LPAF 16:0-d4, Cayman Chemical); 17:1 lysophosphatidylcholine (LPC 17:1), 17:1 lysophosphatidylethanolamine (LPE 17:1), and 17:1 lysophosphatidylserine (LPS 17:1) from Avanti Polar Lipids. LC–MS analysis was performed on a QTrap 6500 mass spectrometer (AB Sciex) coupled with an Acquity I-class UPLC (Waters). Analytes were detected using multiple reaction monitoring (MRM) in the negative-ion mode. Data were analyzed by using the MultiQuant software (AB Sciex) and peak areas were used for relative quantification.

Medved J., Knott B.M., Tarrah S.N., Li A.N., Shah N., Moscovich T.C., Boscia A.R., Salazar J.E., Santhanakrishnan M., Hendrickson J.E., Fu X., Zimring J.C, & Luckey C.J. (2021). The lysophospholipid-binding molecule CD1D is not required for the alloimmunization response to fresh or stored RBCs in mice despite RBC storage driving alterations in lysophospholipids. Transfusion, 61(7), 2169-2178.

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Lysophospholipid Receptor Antagonist Assay

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AA, a mixture of AAI and AAII, was purchased from Across Organics (Geel, Belgium). Ki16425, an LPA₁, ₃ receptor antagonist, was obtained from Cayman Chemical (Ann Arbor, MI, USA). Sepasol RNA I super and polyethylene glycol #400 were obtained from Nakarai tesque (Kyoto, Japan). 1-Heptadecanoyl (17:0) LPC, 1-heptadecenoyl (17:1) lysophosphatidylinositol (LPI), 17:0 lysophosphatidylglycerol (LPG), 17:0 lysophosphatidylethanolamine (LPE), and 17:0 lysophosphatidylserine (LPS) were purchased from Avanti Polar Lipids (Alabaster, AL, USA). 17:0 LPA was prepared from 17:0 LPC using phospholipase D from Streptomyces chromofuscus as described previously [12] (link). Egg yolk phosphatidylcholine (PC), 1-palmitoyl LPC, and 1-palmitoyl LPA as standards for TLC were obtained from Funakoshi Co. (Tokyo, Japan). Alzet™ osmotic pumps were purchased from Durect (Cupertino, CA, USA). Chow (MF) purchased from Oriental Yeast (Tokyo, Japan) had the following components: powders of wheat, defatted soybean, alfalfa, defatted rice, defatted bovine milk, soybean oil, corn, white fish meal, and beer yeast.

Tsutsumi T., Yamakawa S., Ishihara A., Yamamoto A., Tanaka T, & Tokumura A. (2015). Reduced kidney levels of lysophosphatidic acids in rats after chronic administration of aristolochic acid: Its possible protective role in renal fibrosis. Toxicology Reports, 2, 121-129.

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