B6 129 mavstm1zjc j

Manufactured by Jackson ImmunoResearch

B6;129-Mavstm1Zjc/J is a transgenic mouse strain that expresses a mutant form of the mouse Mast Cell Function-associated Antigen (Mast) gene. The core function of this product is to serve as a research model for studying the effects of the Mast gene mutation on various biological processes.

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2 protocols using b6 129 mavstm1zjc j

Rotavirus Infection in Genetically Modified Mice

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B6129SF2/J wild-type and Mavs^-/- mice (B6;129-Mavs^tm1Zjc/J) were purchased from the Jackson laboratory (stock number: 101045 and 008634 respectively) and bred in-house at the Veterinary Medical Unit of Palo Alto VA Health Care System (PAVAHCS). C57/BL6, Ifnar1^-/-, Casp1^-/-, Il18^-/-, Nlrp9b^-/- were used as previously described (Lin et al., 2016 (link); Zhu et al., 2017 (link)). For all RV infections, sex and age-matched suckling pups at 5 days of age were used and whenever possible, littermates were used to minimize the effect of specific microbiome differences on the experiments.
IEC isolation by EDTA-DTT extraction method and flow cytometry of mature villous IECs were performed as previously described (Sen et al., 2012 (link)). Fecal shedding of viral antigens, and detection of RV replication by RT-qPCR were performed as described (Li et al., 2017 (link)).

Ding S., Zhu S., Ren L., Feng N., Song Y., Ge X., Li B., Flavell R.A, & Greenberg H.B. (2018). Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells. eLife, 7, e39494.

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Murine Models for Immunological Studies

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Female C57BL/6J (stock 000664), B6.Cg-Ptprc^aPepc^b Tg(TcrLCMV)1Aox/Ppmj (SMARTA-1; stock 030450), B6.129S(C)-Batf3^tm1Kmm/J (Batf3 knockout; stock 013755), B6(Cg)-Sting1^tm1.2Camb/J (Sting-1 knockout; stock 025805), B6.129S6-Clec7a^tm1Gdb/J (Dectin-1 knockout; stock 012337), B6.129P2(SJL)-Myd88^tm1.1Defr/J (Myd88 knockout, stock 009088), C57BL/6J-Ticam1Lps2/J (Trif knockout, stock 005037), B6.129-Mavs^tm1Zjc/J (MAVS knockout, stock 008634), B6.Cg-Ifih1^tm1.1Cln/J (Mda5 knockout, stock 015812), B6.129S2-H2dlAb1-Ea/J (MHC class II knockout; stock 003584), Il17a^{tm1.1(icre)Stck}/J (IL-17a knockout; stock 016879), B6.129P2-Rorc^tm1Litt/J (RORγt knockout; stock 007571) and B6.129S2-Cd8a^tm1Mak/J (CD8a knockout; 002665) mice were obtained from the Jackson Laboratories. OT-II⁺ TCRα^−/− CD45.1^+/+(OT-II) mice were kindly provided by Arlene Sharpe (Harvard Medical School, Boston, USA). Animals were housed in specific pathogen free and BSL2 conditions at The University of Chicago, and all experiments were performed in accordance with the US National Institutes of Health Guide for the Care and Use of Laboratory Animals and approved by The University of Chicago Institutional Animal Care and Use Committee.

Pandey S., Gruenbaum A., Kanashova T., Mertins P., Cluzel P, & Chevrier N. (2020). Pairwise Stimulations of Pathogen-Sensing Pathways Predict Immune Responses to Multi-Adjuvant Combinations. Cell systems, 11(5), 495-508.e10.

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