Omeprazole

Manufactured by Tokyo Chemical Industry

Sourced in Japan

Omeprazole is a proton pump inhibitor (PPI) used to reduce gastric acid production. It is a white to off-white crystalline powder that is soluble in water and alcohol. Omeprazole functions by inhibiting the H+/K+-ATPase enzyme system, which is responsible for the final step in gastric acid secretion.

Automatically generated - may contain errors

Lab products found in correlation

Potassium phosphate dibasic, by Merck Group (1 mentions) Methanol chromasolv, by Merck Group (1 mentions) Verapamil, by Merck Group (1 mentions)

3 protocols using omeprazole

Amlodipine-Omeprazole Compatibility Assessment

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Amlodipine besilate and omeprazole were obtained from Tokyo Chemical Industry Ltd., Oxford, UK. Amlodipine besilate (5 mg tablets) and omeprazole (20 mg gastro-resistant capsules) were obtained from Teva Ltd., Castleford, UK. Orablend^® was obtained from Fagron, Newcastle upon Tyne, UK. Polyfuser B, the sodium bicarbonate solution (8.4%), was purchased from Fresenius Kabi, Chesire, UK. All other reagents for HPLC analysis, including potassium phosphate dibasic (≥99.0%) and methanol CHROMASOLV^® (≥99.0%) were purchased from Sigma-Aldrich, Dorset, UK.

Kirkby M., Moffatt K., Rogers A.M., McCague P.J., McElnay J.C., Quinn C., McCullough L.A., Barry J, & Donnelly R.F. (2020). A Drug Content, Stability Analysis, and Qualitative Assessment of Pharmacists’ Opinions of Two Exemplar Extemporaneous Formulations. Molecules, 25(13), 3078.

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Synthesis and Quantification of Omeprazole Metabolites

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Omeprazole was acquired from Tokyo chemical industry (Nihonbashi-honcho, Tokyo, Japan) while D3–Omeprazole was acquired from Cayman chemical (Ann Arbor, MI 48108, USA). Verapamil was obtained from Merck & Sigma–Aldrich (Yong-in, Gyeonggi-Do, Korea). Dimethyl sulfoxide (DMSO), formic acid, methanol (MeOH), HPLC grade acetonitrile (ACN) and HPLC grade distilled water (DW) were all obtained from Duksan reagents (Ansan, Gyeonggi-Do, Korea).

Shin S.H., Park Y., Park M.H., Byeon J.J., Lee B.I., Choi J, & Shin Y.G. (2020). Profiling and Identification of Omeprazole Metabolites in Mouse Brain and Plasma by Isotope Ratio-Monitoring Liquid Chromatography-Mass Spectrometric Method. Life, 10(7), 115.

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Omeprazole Treatment in LDO Differentiation

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LDOs in DM with doxycycline at 2 µg/mL on day 5 for differentiation induction were treated with 100-µM omeprazole (Tokyo Chemical Industry Co., Japan) in DM for 48 hours. mRNA was extracted and subjected to qRT-PCR.

Tomofuji K., Kondo J., Onuma K., Coppo R., Horie H., Oyama K., Miyoshi E., Fukumitsu K., Ishii T., Hatano E, & Inoue M. (2023). Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors. Hepatology Communications, 7(5), e0134.

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