The Dade Behring N Latex Cystatin C assay is a particle-enhanced nephelometric assay (PENIA). It was utilized to assess Cystatin C levels in blood samples. This assay was performed on the Dade Behring Nephelometer II (BNII; Finney et al., 1997 (link)). According to Newman’s (2002) (link) assessment of various assay methodologies, the current assay is the most accurate and precise among automated assays across the clinical concentration range, with an intra-assay imprecision range between 2.0 and 3.0% coefficient of variation. The inter-assay imprecision range is between 3.2 and 4.4% coefficient of variation. Additionally, the assay range is between 0.23 and 7.25 mg/dl. Newman also found that this assay had superior sensitivity and lacked analytical interference compared to other automated assays. The participants’ serum Cystatin C level was categorized into four groups (quartile one, quartile two, quartile three, and quartile four).
N latex cystatin c assay
Manufactured by Siemens
The N Latex Cystatin C assay is a laboratory equipment product designed to measure cystatin C levels in human serum or plasma samples. Cystatin C is a protein that is produced at a relatively constant rate by all nucleated cells and is filtered by the kidneys. The assay provides a quantitative determination of cystatin C concentrations, which can be used as an indicator of kidney function.
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4 protocols using n latex cystatin c assay
1
Cystatin C Assay Precision and Accuracy
2
Cystatin C Measurement in Children
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Cystatin C was measured by a particle-enhanced immunonephelometric assay (N Latex Cystatin C assay; Dade Behring, Deerfield, IL) using a nephelometer (BN-II; Dade Behring). The normal value for children between 4 and 12 years of age was defined as 0.53–0.95 mg/l. The same method was used to evaluate cystatin C levels in children 7 and 11 years of age.
3
NHANES Creatinine Measurement Harmonization
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NHANES 1999–2000 creatinine measurements used the Jaffe kinetic alkaline picrate method, while NHANES 2001–2002 used a Roche coupled enzymatic analysis, at the Cleveland Clinic Foundation (CCF) laboratory. There were significant differences in results between these two measurements. We referred to the official NHANES analysis notes and corrected the values for 1999–2000 according to the CCF laboratory standards by multiplying by 1.013 and then adding 0.147 (Nhanes-1999–2000, Standard Biochemistry Profile & Hormones). All assays of cystatin C were conducted using the Dade Behring N Latex Cystatin C assay (14 (link)).
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Standardizing Serum Creatinine and Cystatin C Measurements in NHANES
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NHANES 1999–2000 serum creatinine measurements used the Jaffe kinetic alkaline picrate method, while NHANES 2001–2002 used a Roche coupled enzymatic analysis, at the Cleveland Clinic Foundation (CCF) laboratory. There were significant differences in results between these two measurements. We referred to the official NHANES analysis notes and corrected the values for 1999–2000 according to the CCF laboratory standards by multiplying by 1.013 and then adding 0.147. Serum cystatin C was only measured in the NHANES 1999–2002. Serum cystatin C was measured in a subset of 4261 participants, including all participants aged 60 years or older with available specimens and a 25% random sample of participants aged 12 to 59 years. All assays of cystatin C were conducted using the Dade Behring N Latex Cystatin C assay.12 Detailed specimen collections and processing instructions for other indicators are provided in the NHANES Laboratory Procedures Manual, which is available on the NHANES website.
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