Voriconazole

Manufactured by Thermo Fisher Scientific

Sourced in United Kingdom

Voriconazole is a pharmaceutical product used as an antifungal agent. It is designed to inhibit the growth of various types of fungal organisms. The core function of Voriconazole is to provide an effective treatment option for fungal infections.

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Lab products found in correlation

Chloramphenicol, by Thermo Fisher Scientific (3 mentions) Sabouraud dextrose agar, by Thermo Fisher Scientific (3 mentions) Mueller hinton agar, by Thermo Fisher Scientific (3 mentions) Fluconazole, by Thermo Fisher Scientific (2 mentions) Nystatin, by Merck Group (2 mentions) Caspofungin, by Merck Group (2 mentions) Rpmi 1640 media, by Thermo Fisher Scientific (1 mentions) Fluconazole, by Pfizer (1 mentions) Itraconazole, by Thermo Fisher Scientific (1 mentions) Whatman, by Cytiva (1 mentions)

5 protocols using voriconazole

Antifungal and Antibacterial Susceptibility Testing

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Fluconazole, voriconazole, chloramphenicol, Mueller-Hinton (MH) agar and Sabouraud Dextrose Agar (SDA) were obtained from Thermo Fisher (Oxoid Limited, Hampshire, UK). All the organic solvents were purchased from BDH laboratory supplies (Merck Ltd, Lutterworth, UK).

Harley B.K., Neglo D., Tawiah P., Pipim M.A., Mireku-Gyimah N.A., Tettey C.O., Amengor C.D., Fleischer T.C, & Waikhom S.D. (2021). Bioactive triterpenoids from Solanum torvum fruits with antifungal, resistance modulatory and anti-biofilm formation activities against fluconazole-resistant candida albicans strains. PLoS ONE, 16(12), e0260956.

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Comparative Antifungal Susceptibility Assay

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Fluconazole, Mueller-Hinton (MH) agar, voriconazole, Sabouraud Dextrose Agar (SDA), and chloramphenicol were bought from Thermo Fisher (Oxoid Limited, Hampshire, UK). Nystatin and caspofungin were bought from Sigma Aldrich (St. Louis, MO, United States).

Harley B.K., Neglo D., Aggrey M.O., Quagraine A.M., Orman E., Jato J., Mireku-Gyimah N.A., Amengor C.D, & Fleischer T.C. (2022). Antifungal Activities of Phytochemically Characterized Hydroethanolic Extracts of Sclerocarya birrea Leaves and Stem Bark against Fluconazole-Resistant Candida albicans Strains. BioMed Research International, 2022, 4261741.

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Antifungal Drug Susceptibility Assay

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Sabouraud Dextrose Agar (SDA), Mueller-Hinton (MH) agar, RPMI 1640 media, XTT assay reagent, voriconazole and chloramphenicol were obtained from Thermo Fisher (Oxoid Limited, Hampshire, UK). Other drugs used in the experiment include fluconazole (Pfizer Inc., New York, NY, United States), nystatin and caspofungin (Sigma Chemical Co., St. Louis, MO, United States).

Harley B.K., Quagraine A.M., Neglo D., Aggrey M.O., Orman E., Mireku-Gyimah N.A., Amengor C.D., Jato J., Saaka Y, & Fleischer T.C. (2022). Metabolite profiling, antifungal, biofilm formation prevention and disruption of mature biofilm activities of Erythrina senegalensis stem bark extract against Candida albicans and Candida glabrata. PLOS ONE, 17(11), e0278096.

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Disk Assay for Antifungal Persistence

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To determine persistence using the disc assay, 4 × 10⁴ conidia of each isolate was evenly spread on a solidified RPMI plate (1.5% agar), and 10 μL of 0.8 mg/mL voriconazole or 3.2 mg/mL itraconazole (Acros Organics) was added to a Whatman 6-mm antibiotic assay disc, which was placed in the middle of the plate. For in vitro treatment with adjuvant and combinatorial drugs, the agents were added to the RPMI medium at the final concentration detailed in each section. Plates were incubated for 5 days at 37°C. Persister colonies were defined as those with a degree of physical separation from the edge of the loan of growth into the halo of inhibition.
MICs were calculated using the broth microdilution method according to EUCAST E.Def. 9.3 instructions (128 (link)). A total of 2.5 × 10⁴ conidia were used in each well.

Scott J., Valero C., Mato-López Á., Donaldson I.J., Roldán A., Chown H., Van Rhijn N., Lobo-Vega R., Gago S., Furukawa T., Morogovsky A., Ben Ami R., Bowyer P., Osherov N., Fontaine T., Goldman G.H., Mellado E., Bromley M, & Amich J. (2023). Aspergillus fumigatus Can Display Persistence to the Fungicidal Drug Voriconazole. Microbiology Spectrum, 11(2), e04770-22.

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Cytotoxicity Evaluation of Voriconazole

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Voriconazole was purchased from Acros Organics (Geel, Belgium). 2-hydroxypropyl-β-cyclodextrin Human fibronectin was purchased from Roche Diagnostics (Mannheim, Germany). 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was purchased from Tocris/Bio-Techne (Bristol, UK).

Morgan S.R., Pilia N., Hewitt M., Moses R.L., Moseley R., Lewis P.N., Morrison P.W.J., Kelly S.L., Parker J.E., Whitaker D., Quantock A.J, & Heard C.M. (2020). Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis. International journal of pharmaceutics, 579.

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