Three-dimensional sagittal T1-weighted images were acquired using three 3.0-Tesla MR scanners from the three hospitals, including two Discovery MR750 scanners (General Electric, Milwaukee, WI, USA) and a Magnetom Trio Tim MR scanner (Siemens, Erlangen, Germany). The repetition time (ms)/echo time (ms)/flip angle/matrix/slices were 8.2/3.2/11°/256 × 256/188 for the MR750 scanner and 2000/2.3/9°/256 × 232/192 for the Trio Tim scanner. All scans used the same field of view (256 mm × 256 mm), slice thickness (1 mm and no gap) and spatial resolution (1 × 1 × 1 mm3).
Discovery mr750 scanner
Manufactured by GE Healthcare
Sourced in United States
The Discovery MR750 scanner is a magnetic resonance imaging (MRI) system designed and manufactured by GE Healthcare. It is a powerful diagnostic tool that uses strong magnetic fields and radio waves to generate detailed images of the body's internal structures. The core function of the Discovery MR750 scanner is to provide high-quality imaging for medical professionals to aid in the diagnosis and treatment of various conditions.
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Lab products found in correlation
Discovery mr750w scanner, by GE Healthcare (3 mentions)
Magnetom trio tim mr scanner, by Siemens (2 mentions)
Tim trio system scanner, by GE Healthcare (2 mentions)
Biograph mct pet computed tomography scanner, by Siemens (2 mentions)
Biograph 6 truepoint pet computed tomography scanner, by Siemens (2 mentions)
Tim trio or skyra scanner, by Siemens (2 mentions)
Tim trio or prisma scanner, by Siemens (2 mentions)
Discovery 690 pet scanner, by GE Healthcare (2 mentions)
High resolution research tomograph scanner, by Siemens (2 mentions)
Discovery and discovery mi pet scanners, by GE Healthcare (2 mentions)
3.0t tim trio or prisma scanner, by Siemens (2 mentions)
3.0 tim trio scanner, by Siemens (2 mentions)
Biograph mct pet ct scanner, by Siemens (2 mentions)
Biograph 6 truepoint pet ct scanner, by Siemens (2 mentions)
Tim trio system, by GE Healthcare (1 mentions)
Eight channel head coil, by Siemens (1 mentions)
Tim trio mri scanner, by Siemens (1 mentions)
Signa hdx scanner, by GE Healthcare (1 mentions)
Nova medical 32 channel head coil, by GE Healthcare (1 mentions)
32 channel head coil, by GE Healthcare (1 mentions)
97 protocols using discovery mr750 scanner
1
Standardized 3D T1-weighted MRI Acquisition
2
Multimodal Brain Imaging in Infants
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All participants participated in multiple scans in each session to obtain anatomical MRI, qMRI, and dMRI data. Data were acquired at two identical 3T GE Discovery MR750 Scanners (GE Healthcare) and Nova 32-ch head coils (Nova Medical) located at Stanford University: (i) Center for Cognitive and Neurobiological Imaging (CNI) and (ii) Lucas Imaging Center using identical acquisition sequences and protocols. Prior work has shown that quantitative imaging metrics are replicable across scanners and subjects and have low intersite discrepancies68 (link),69 (link). As infants have low weight, all imaging was done with Normal SAR level to ensure their safety.
3
Standardized 3D T1-weighted MRI Acquisition
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Three-dimensional sagittal T1-weighted images were acquired using three 3.0-Tesla MR scanners from the three hospitals, including two Discovery MR750 scanners (General Electric, Milwaukee, WI, USA) and a Magnetom Trio Tim MR scanner (Siemens, Erlangen, Germany). The repetition time (ms)/echo time (ms)/flip angle/matrix/slices were 8.2/3.2/11°/256 × 256/188 for MR750 scanner, and 2000/2.3/9°/256 × 232/192 for Trio Tim scanner, respectively. All scans used the same field of view (256 mm × 256 mm), slice thickness (1 mm and no gap) and spatial resolution (1 × 1 × 1 mm3).
4
Multimodal MRI Acquisition Protocol for Stroke Evaluation
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Two Discovery MR750 scanners (General Electric, Milwaukee, WI, USA) in two hospitals were utilized to obtain MRI data from all patients. We captured DWI, T1-weighted (T1WI), T2-weighted (T2WI), and T2 fluid-attenuated inversion recovery (T2-FLAIR) images to identify stroke lesions, white-matter hyperintensity, and relapsed stroke or additional brain abnormalities. The DWI parameters were as follows: repetition time (TR) = 3,000 ms; echo time (TE) = 61 ms; matrix = 160 × 160; field of view (FOV) = 240 mm × 240 mm; slices = 20; slice thickness = 6 mm; b-value = 1,000 s/mm2. In addition, clinical standard sequences were utilized to obtain T1WI and T2WI, and the voxel size was 0.5 mm × 0.5 mm × 6 mm. Moreover, parameters used for T2-FLAIR included TR/TE/matrix/slices/slice thickness = 8,500 ms/158 ms/256 × 256/20/5 mm, respectively.
Brain volume sequences were applied in acquiring sagittal three-dimensional T1WIs for calculating cortical structural measures using the following parameters: TR/TE/flip angle/matrix/FOV/slices/slice thickness/voxel size = 8.2 ms/3.2 ms/11°/256 × 256/256 mm × 256 mm/188/1 mm/1 mm × 1 mm × 1 mm, respectively.
Brain volume sequences were applied in acquiring sagittal three-dimensional T1WIs for calculating cortical structural measures using the following parameters: TR/TE/flip angle/matrix/FOV/slices/slice thickness/voxel size = 8.2 ms/3.2 ms/11°/256 × 256/256 mm × 256 mm/188/1 mm/1 mm × 1 mm × 1 mm, respectively.
5
Comprehensive Abdominal MRI Protocol
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Abdominal MRIs were performed in a supine position with 1.5-T, 3-T, and 750 W MR scanners, including GE MR Singna HDX 3.0T, GE MR Singna HD Excite scanners 1.5T, Simen MR Skyra 3.0T, Simen magnetom avanto Dot1.5T, and GE discovery MR 750 scanners. T2-weighted sequence, diffusion-weighted sequence (b-values: 800 s/mm2) from standard institutional liver MR imaging protocols were performed with acquisition times of 2–2.5 and 2–2.5 min. Contrast-enhanced T1 sequences were used with acquisition times of 12–18 s. Two different contrast agents were used, i.e., Gadopentetate dimeglumine and Gadoxetic Acid Disodium (Primovist) at doses of 0.2 and 0.1 mmol/kg, respectively. Except for pre-contrast T1, T2, and diffusion images, post- contrast images were analyzed, including late arterial phase (~15 s post-injection), portal venous phase (~60 s post-injection), and equilibrium phase (~3 min post- injection). Imaging parameters varied across different scanners and time frames (Table S4 ).
6
3.0T MRI Acquisition Protocol for Neuroimaging
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MRI acquisition for all participants was performed at the Department of Neuroradiology, Walton Centre NHS Foundation Trust using a 3.0 Tesla General Electric Discovery MR750 scanner with a 32‐channel head coil. Sequences used for analysis in this paper included: (a) 3D axial T1w fast spoiled gradient echo (FSPGR) MRI with Phased Array Uniformity Enhancement (PURE) signal inhomogeneity correction (pulse sequence = BRAVO; TR = 8.2 ms, TI = 450 ms, TE = 3.22 ms, flip angle = 12, slice thickness = 1 mm, voxel size = 0.94 mm × 0.94 mm, 136 slices, FOV = 24 cm) and (b) resting‐state functional MRI using a gradient echo EPI sequence (TR = 2000 ms, TE = 25 ms, flip angle = 75, slice thickness = 2.4 mm, voxel size = 3.75 mm × 3.75 mm, 180 volumes, 38 slices, FOV = 24 cm). No task was used, and sedation was not administered during scanning. For all participants, image acquisition was performed while awake and with visual fixation on a white crosshair with a black background.
7
Multimodal Brain Connectivity Analysis
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Neuroimaging data of resting-state functional MRI (rs-fMRI) and DTI for all participants were acquired by a 3.0T GE Discovery MR750 scanner in the Center for MRI Research, Peking University. After preprocessing, 274 samples with brain maps of ReHo for rs-fMRI and FA for DTI were obtained. The three-dimensional brain image of each subject was reshaped into a one-dimensional vector and stacked, forming a subject by voxel matrix (FA: 274 × 59 155; ReHo: 274 × 77 039).
Details for data collection and preprocessing are provided in Supplementary Methods.
Details for data collection and preprocessing are provided in Supplementary Methods.
8
Resting-state fMRI Acquisition Protocol
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All participants provided written informed consent before scanning. Resting-state fMRI scans were collected at seven sites using a 3T Siemens Tim Trio System scanner in six locations and a 3T General Electric Discovery MR750 scanner in one location. Participants were asked to lay still, stay awake and keep their eyes closed during the whole scan duration. In all sites, T2∗-weighted gradient-echo echo-planar images (EPIs) were acquired with the following parameters: voxel size = 3.4375 × 3.4375 × 4.0 mm3, repetition time (TR) = 2 s, eco time (TE) = 30 ms, flip angle (FA) = 77 degrees, field of view (FOV) = 220 × 220 mm (64 × 64 matrix), slice thickness = 4 mm, gap = 1 mm, number of slices = 32 sequential ascending slices. Scans lasted 5:4 min, a total of 162 volumes of echo planar imaging BOLD fMRI were collected.
9
Resting-state fMRI analysis of schizophrenia
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In this work, we analyzed eyes-closed resting-state fMRI data collected from 160 controls and 151 age, gender, and mean framewise displacement (FD)–matched individuals with schizophrenia (SZ) (age: p = 0.18; gender: p = 0.39; mean FD: p = 0.97) by the Function Biomedical Informatics Research Network (fBIRN) (Keator et al., 2016 (link)). fBIRN demographics are available in Supporting Information Table S1 . Written informed consent was obtained from all subjects. Data were collected using 3T scanners with a repetition time (TR) of 2 s, voxel spacing size of 3.44 × 3.44 × 4 mm, a slice gap of 1 mm, and a total of 162 volumes at seven different sites. Data for six of the seven sites were collected on a 3T Siemens Tim Trio System, and for one other site, a 3T General Electric DiscoveryMR750 scanner was used. Further details on the dataset can be found in Fu, Iraji, et al. (2021) (link) and Fu, Sui, et al. (2021) (link).
10
3T MRI Imaging Protocol Comparison
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