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Tina quant d dimer

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Tina-quant D-dimer is a quantitative assay for the measurement of D-dimer in human plasma or serum. D-dimer is a fibrin degradation product that is used as a marker for the activation of the coagulation and fibrinolytic systems.

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Lab products found in correlation

Multifibren u, by Siemens (3 mentions) Actin fsl, by Siemens (3 mentions) Nycotest pt, by Axis-Shield (3 mentions) Enzygnost f1 2, by Siemens (2 mentions)

5 protocols using tina quant d dimer

1

Platelet Function and Coagulation Markers

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Measurement of MPV and IPF% as well as the assessment of platelet functions with PFA-100 and Multiplate is described in detail in our recent article.[10 (link)]Fibrinogen was measured with a modification of the Clauss method (Multifibren U, Siemens Healthcare Diagnostics), d-dimer with an immunoturbidimetric assay (Tina-quant D-Dimer, Roche Diagnostics, Mannheim, Germany), and F1 + 2 with an enzyme immunoassay (Enzygnost F1 + 2, monoclonal, Siemens Healthcare Diagnostics). The reference values were 1.7 to 4.0 g/L for fibrinogen, ≤0.5 mg/L for d-dimer, and 69 to 229 pmol/L for F1 + 2.
Laine O., Joutsi-Korhonen L., Lassila R., Huhtala H., Vaheri A., Mäkelä S, & Mustonen J. (2016). Elevated thrombopoietin and platelet indices confirm active thrombopoiesis but fail to predict clinical severity of puumala hantavirus infection. Medicine, 95(52), e5689.
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2

Coagulation Profile Assessment Protocol

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Citrated 3.2% plasma was used for coagulation samples. Prothrombin time was analyzed with Nycotest PT (Axis-Shield PoC As, Oslo, Norway) and APTT with Actin FSL (Siemens Healthcare Diagnostics, Marburg, Germany, and all following reagents provided by Siemens are from the same source). Fibrinogen levels were determined using Multifibren U (Siemens and BC Thrombin Reagent (Siemens) was used to determine TT. Factor VIII: C (FVIII) was analyzed with a 1-stage clotting assay (Pathromtin SL and Coagulation Factor VIII Deficient Plasma; Siemens) and AT was measured with a chromogenic assay (Berichrom Antithrombin III; Siemens). D-dimer levels were measured with an immunoturbidimetric assay (Tina-quant D-dimer; Roche Diagnostics, Mannheim, Germany).
Mattila N., Seppänen H., Mustonen H., Przybyla B., Haglund C, & Lassila R. (2018). Preoperative Biomarker Panel, Including Fibrinogen and FVIII, Improves Diagnostic Accuracy for Pancreatic Ductal Adenocarcinoma. Clinical and Applied Thrombosis/Hemostasis, 24(8), 1267-1275.
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3

Thromboembolic Events Coagulation Profile

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We recorded thromboembolic events and collected the coagulation and fibrinolysis index profile of these patients. The thromboembolic events were recorded according to vascular ultrasound and computed tomography. Since this was a retrospective analysis, the individual method employed was based solely on the treating physician's choice. The coagulation and fibrinolysis index, including plasma prothrombin time (PT) (Nycotest PT, Axis-Shield Poc As, Oslo, Norway, the normal range of PT is between 9.8 and 12.4 sec), activated partial thromboplastin time (APTT) (Actin FSL Siemens Healthcare Diagnostics, Marburg, Germany, the normal range of APTT is between 26.9 and 37.6 sec), D-dimer (Tina-quant D-dimer, Roche Diagnostics, Mannheim, Germany, the normal range of D-dimer is between 0.1–0.5mg/L) and fibrin degradation products (FDP) (SpliPrest, Diagnostica Stago, the normal range of FDP is between 0 and 5 mg/L), were measure by the Central Laboratory Department of our hospital. The D-dimer was in Fibrinogen units. The International Sensitivity Index (ISI) value for the PT assay ranged from 0.96 to 0.99. During the fibrinolysis, dissolution of crosslinked fibrin leads to formation of specific degradation products, including D-dimer [9] (link). A normal D-dimer value excludes the diagnosis of venous thrombosis, while an elevated value supports it [10] (link).
Ma T.T., Huang Y.M., Wang C., Zhao M.H, & Chen M. (2014). Coagulation and Fibrinolysis Index Profile in Patients with ANCA-Associated Vasculitis. PLoS ONE, 9(5), e97843.
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4

Comprehensive Coagulation Profile Analysis

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Citrated 3.2% plasma was analyzed for PT with Nycotest PT (Axis-Shield PoC As, Oslo, Norway) and APTT with Actin FSL (Siemens Healthcare Diagnostics, Marburg, Germany, also providing the following reagents). Fibrinogen levels were determined using Multifibren U, and BC Thrombin Reagent was used for TT. FVIII was analyzed with a one-stage clotting assay (Pathromtin SL and Coagulation Factor VIII Deficient Plasma), and antithrombin (AT) was measured with a chromogenic assay (Berichrom Antithrombin III). D-dimer levels were captured with an immunoturbidimetric assay (Tina-quant D-dimer; Roche Diagnostics, Mannheim, Germany).
Matilainen S., Kask G., Nieminen J., Lassila R, & Laitinen M. (2022). Preoperative coagulation biomarkers associate with survival and pulmonary embolism after surgical treatment of non-spinal skeletal metastases. Thrombosis Journal, 20, 70.
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5

Coagulation Markers in Acute CAT®

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The study design was longitudinal with two time-points of blood draw for CAT®. The acute phase samples (n=27) were taken median 7 days (range 4-12 days) from the onset of fever. Control samples (n=23) were taken at the follow-up visit, median 43 days (range 38-76 days) from the onset of fever. The blood count was assessed in the acute and control phase of CAT® study days, and the lowest platelet count during the hospital stay was recorded.
CAT® analyses and plasma measurements of fibrinogen, F1+2 and D-dimer were carried out in Clinical Chemistry coagulation laboratory (HUSLAB Laboratory Services, Helsinki University Central Hospital, Finland). D-dimer (Tina Quant D-Dimer®, Roche Diagnostics, Mannheim, Germany) and fibrinogen (Multifibren U® Siemens Healthcare Diagnostics) levels were determined according to manufacturer's recommendations. F1+2 were measured by an enzyme immunoassay (Enzygnost® F1+2, monoclonal, Siemens Healthcare Diagnostics). The reference values for D-dimer were ≤ 0.5 mg/l, fibrinogen 1.7-4.0 g/l and F1+2 69-229 pmol/l.
Koskela S.M., Joutsi-Korhonen L., Mäkelä S.M., Huhtala H., Vaheri A.I., Pörsti I., Mustonen J.T, & Laine O.K. (2018). Diminished coagulation capacity assessed by calibrated automated thrombography during acute Puumala hantavirus infection. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 29(1).
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