Magnetom trio a 3t mr scanner

Before scanning, the participants were told to remain at rest and awake without thinking or falling asleep. Their heads were fixed to reduce any head motion. The images were collected by using a Magnetom Trio A 3T MR Scanner (Siemens AG, Erlangen, Germany). Rs-fMRI images were acquired using a Gradient Echo-Echo Planar Imaging (GRE-EPI) sequence with the following parameters: interleaved scanning order; Field of view = 240 × 240 mm²; matrix size = 64 × 64; slice number = 43; Time of repetition/echo = 3000/30 ms; flip angle = 90°; slice thickness = 3.0 mm; acquisition voxel size = 3.4 × 3.4 × 3.2 mm³; and number of repetitions = 240. The Graph-theoretical Network Analysis Toolkit (GRETNA, www.nitrc.org) was applied for data preprocessing as follows: remove the first 10 volume, slice timing, realignment, normalization by the EPI template of the Montreal Neurological Institute (MNI) space, resampling to 3.0 × 3.0 × 3.0 mm³, spatial smoothing with a 4-mm full-width at half-maximum Gaussian kernel, temporal detrending and filtering (0.01–0.1 Hz), regressing out of covariates. Finally, the data from four HCs and three patients were excluded because of excessive head motion (more than 2° and 2 mm) or serious artifacts. The data of forty-six participants were analyzed in the next steps.