SSR-PET/CT scans were acquired on a Discovery 64-slice PET/CT scanner (GE Healthcare) (n = 33) or a Biograph 64 TruePoint w/TrueV and Biograph mCT Flow 20-4R PET/CT scanner (Siemens, Healthcare GmbH, Erlangen, Germany) (n = 2350) and were initiated approximately 60 min after intravenous administration of a standard amount of approx. 180 MBq radiolabelled somatostatin analogues (68Ga-DOTATOC and 68Ga-DOTATATE). After intravenous injection of contrast agent 1.5 times the body weight (Ultravist 300, Bayer Vital GmbH, Leverkusen, Germany or Imeron 350 mg/mL, 2.5 ml/s, Bracco Imaging Deutschland GmbH, Konstanz, Germany) diagnostic venous-phase CT scans of the neck, thorax, abdomen, and pelvis (100–190 mAs; 120 kV) were acquired. Patients received diagnostic CT scan without contrast enhancement in case of known allergic reactions to iodinated contrast agent, renal impairment/failure or hyperthyreoidism. Imaging construction was automatically performed using built-in software. 3 mm-slice reconstructions were used for reading.
Imeron 350
Manufactured by Bracco
Sourced in Germany, Italy
Imeron 350 is a contrast agent used in medical imaging procedures. It is a water-soluble, iodinated compound that is administered intravenously to enhance the visibility of organs and blood vessels during diagnostic imaging tests.
Automatically generated - may contain errors
Lab products found in correlation
Somatom force, by Siemens (5 mentions)
Ultravist 300, by Bayer (5 mentions)
Biograph mct flow 20 4r pet ct scanner, by Siemens (3 mentions)
Biograph 64 pet ct scanner, by Siemens (3 mentions)
Biograph mct scanner, by Siemens (3 mentions)
Somatom sensation 64, by Siemens (2 mentions)
Corevalve evolut r, by Medtronic (2 mentions)
Somatom definition as, by Siemens (2 mentions)
Discovery 64 slice pet ct scanner, by GE Healthcare (1 mentions)
Axiom artis zee, by Siemens (1 mentions)
Gemini tf 16, by Philips (1 mentions)
Syngo plaza, by Siemens (1 mentions)
Gammex, by Sun Nuclear (1 mentions)
Iomeprol, by Bracco (1 mentions)
Definition flash, by Siemens (1 mentions)
Lightspeed ultra, by GE Healthcare (1 mentions)
Gastrografin, by Bayer (1 mentions)
Biograph mct flow 20 4r, by Siemens (1 mentions)
Discovery hd 750, by GE Healthcare (1 mentions)
Somatom as, by Siemens (1 mentions)
37 protocols using imeron 350
1
Somatostatin Receptor PET/CT Imaging
2
Dynamic C-arm CBCTP Acquisition Protocol
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Dynamic C-arm CBCTP data were acquired using a biplane flat detector angiographic system (Axiom Artis zee; Siemens Medical Solutions, Forchheim, Germany). Contrast was injected into a peripheral vein with the use of a dual-syringe angiographic power injector (Medtron Accutron HP-D, Saarbrücken, Germany). Sixty milliliters contrast material (Imeron 350; Bracco Imaging, Milan, Italy) was injected at a rate of 5 mL/s followed by 60-mL saline flush. Briefly, nine bidirectional rotational scans (5 forward rotations and 4 reverse rotations) were performed; contrast was injected 5 s after the start of the acquisition so that the first 2 are the baseline set of nonenhanced (mask) images and the following 7 are contrast enhanced (fill) images. Rotation angle was 200° by ≈5-s rotation time each; 248 projections were acquired during each rotation (angulation step 0.80/frame). Each projection was acquired at 77 kVp and 0.36 μGy/frame dose level. This acquisition protocol resulted in a sampling rate of ≈5 s, with a total acquisition duration of 41 s. Clinical dose levels for a state-of-the-art CTP scan with a 16cm (whole head) coverage are on average 5.0 mSv. 25 A multisweep C-arm CBCT acquisition, the basis for perfusion CBCT, exposes the patient to a radiation dose of 4.6 mSv at the same coverage level. 26 (link)
3
Claustrophobia-Friendly FMISO-PET/CT Imaging
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In a single patient with severe claustrophobia, pretherapeutic FMISO-PET/CT was performed instead of PET/MRI. After intravenous injection of 171 MBq [
18F]FMISO (1.8 MBq/kg), PET acquisition was performed with the above-named PET/CT scanner (Philips Gemini TF 16) after 197 min for 15 min in a single bed position (matrix, 144 × 144). PET data were reconstructed with identical parameters as described for FDG-PET/CT imaging. Additionally, a venous-phase contrast enhanced, diagnostic CT (automated tube current modulation; maximum tube current-time product, 200 mAs; tube voltage, 120 kV; FOV, 395 × 395 mm
2; voxel size, 0.77 × 0.77 × 3.0 mm
3) was performed 100 s after intravenous injection of 120 ml of Imeron 350 (bolus rate, 2 ml/s; Bracco Imaging Deutschland GmbH, Konstanz, Germany).
18F]FMISO (1.8 MBq/kg), PET acquisition was performed with the above-named PET/CT scanner (Philips Gemini TF 16) after 197 min for 15 min in a single bed position (matrix, 144 × 144). PET data were reconstructed with identical parameters as described for FDG-PET/CT imaging. Additionally, a venous-phase contrast enhanced, diagnostic CT (automated tube current modulation; maximum tube current-time product, 200 mAs; tube voltage, 120 kV; FOV, 395 × 395 mm
2; voxel size, 0.77 × 0.77 × 3.0 mm
3) was performed 100 s after intravenous injection of 120 ml of Imeron 350 (bolus rate, 2 ml/s; Bracco Imaging Deutschland GmbH, Konstanz, Germany).
4
Dual-Energy CT Imaging Protocol
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All CT-examinations were performed on a 256-slice dual-energy CT-scanner (Siemens Definition Flash; Forchheim, Germany). All patients underwent first unenhanced dual-energy CT using ref. tube current 100mAs (CARE Dose4D) for tube A (100 kV) and ref. 77mAs tube current for tube B (Sn140kV), 0.6 mm single collimation width, table speed of 70 cm/s, table feed per rotation of 23 cm, spiral pitch factor 0.6, matrix 512 x 512 and a reconstruction kernel Q40f. Subsequently, contrast-enhanced CT in the portal-venous phase was performed using 80–100 mL contrast agent volume (Imeron 350, BRACCO Imaging Germany GmbH), a flow of 2mL/s, same slice thickness and collimation parameters as for unenhanced helical using ref. tube current 300mAs (CARE Dose4D) for tube A (100 kV) and ref. 232mAs tube current for tube B (Sn140kV) and reconstruction kernel I 30f/1. Mean "Computed Tomography Dose Index per Volume" (CTDIVol) was 2.824 mGy for unenhanced and 10.286 mGy for enhanced image data sets. A sinogram affirmed iterative reconstruction (SAFIRE) at level1 was used.
5
Standardized PET Imaging Protocol for PSMA-1007
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A median activity of 246 MBq (range 217–268 MBq) 18F-PSMA-1007 was injected intravenously in line with previously reported radiosynthesis and administration procedures [16 (link)]. Additionally, the patients were premedicated with furosemide (20 mg) if no contraindication was given [17 (link)]. The radiopharmaceutical was used on an individual patient basis according to German Pharmaceuticals Act §13(2b). PET was performed from the skull base to the mid-thigh using a Biograph mCT scanner or a Biograph 64 PET/CT scanner (Siemens Healthineers Erlangen, Germany) 60 min after tracer injection. PET/CT included a diagnostic, contrast-enhanced CT scan in the portal–venous phase (Imeron 350; 1.5 ml/kg body weight; Bracco Imaging, Milano, Italy). PET was acquired with 2.5 min per bed position and reconstructed iteratively using TrueX (three iterations, 21 subsets) with Gaussian postreconstruction smoothing (2 mm full-width at half-maximum).
6
Comprehensive Cardiac CT Angiography Protocol
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A dual-source CT scanner (SOMATOM Force, Siemens Healthcare GmbH, Erlangen, Germany) was used to generate contrast-enhanced MDCT scans in a prospectively ECG-triggered high-pitch spiral acquisition mode. The region of interest extended from the clavicles to the femoral heads. CT angiography was performed with bolus tracking in the descending aorta using a contrast agent bolus of 80 ml (Imeron 350, Bracco Imaging, Konstanz, Germany) followed by a 40 ml saline chaser, both at a flow rate of 4 ml/sec. Scan parameters were as follows: 2 × 192 × 0.6 mm collimation, 250 ms rotation time, pitch of 3.2, automated tube current adaption. A small field of view data set with medium soft convolution kernel (Siemens Bv36), 0.75 mm slice thickness and 0.5 mm slice increment was generated for the assessment of the aortic annulus, root, and valve morphology and dimensions. All data were analysed using dedicated software (3 Mensio, Structural Heart, V9.1., Pie Medical Imaging, Maastricht, Netherlands).
7
Standardized CT Imaging Protocol for Distal Tibiofibular Ligaments
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To avoid any technical bias resulting from different CT technologies only patients examined on one particular scanner at our institution (Somatom Sensation 64, Siemens Healthcare, Erlangen, Germany) were included. Scanning parameters (120 kV, 200 eff. mAs, anatomy based tube current modulation) were identical in all examinations. The collimation was 64 x 0.6 mm. Patients were examined in the supine position with their arms lowered. Intravenous contrast media (Imeron 350, Bracco Imaging, Konstanz, Germany) was applied via an antecubital vein at a flow rate of 2.5 ml/s and the scan was started after a delay of 80 seconds.
All examinations were evaluated on a dedicated PACS (Picture Archiving and Communication System) workstation (syngo.plaza, Siemens, Germany). All examinations were anonymized and randomized. A board-certified radiologist (Siegfried A. Schwab) and a Ph.D. student (Benedikt Schlude) evaluated the distal TD and RLD in consensus on axial and coronal 3 mm reconstructions in soft tissue windowing (window 400, center 50).
All examinations were evaluated on a dedicated PACS (Picture Archiving and Communication System) workstation (syngo.plaza, Siemens, Germany). All examinations were anonymized and randomized. A board-certified radiologist (Siegfried A. Schwab) and a Ph.D. student (Benedikt Schlude) evaluated the distal TD and RLD in consensus on axial and coronal 3 mm reconstructions in soft tissue windowing (window 400, center 50).
8
Iodine-Doped Tissue-Mimicking Phantoms
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Phantoms were created from distilled water, agar (Biovita Naturkost GmbH, Hameln, Germany), and 0%, 5%, 10%, 25%, and 40% volume percent of plant fat (Palmin; Peter Kölln GmbH, Elmshorn, Germany). Plant fat was chosen due to its higher melting point, which resulted in more homogeneous phantoms than lard-based approaches. Each fat concentration series was generated with 0, 4.9, and 7.0 mg/mL iodine (Imeron 350; Bracco Imaging, Milan, Italy), which corresponds to concentrations in clinical abdominal CT scans if a patient blood volume between 4 and 5.7 L is assumed and 80 mL of contrast agent are injected. To increase the Compton and photoelectric attenuation of the water, agar mixture such that it was closer to that of liver tissue, 3 g of potassium (Kalinor; DESMA GmbH, Mainz-Kastel, Germany) was added to each phantom.
After the phantoms solidified, drilling cores were made via a 3D-printed (PreForm 2; Formlab, Somerville, MA) drill set and inserted into a multienergy CT phantom (Gammex; Sun Nuclear Corporation, Melbourne, Australia) (Fig.1 A).
After the phantoms solidified, drilling cores were made via a 3D-printed (PreForm 2; Formlab, Somerville, MA) drill set and inserted into a multienergy CT phantom (Gammex; Sun Nuclear Corporation, Melbourne, Australia) (Fig.
9
Multimodal Imaging for Body Composition
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All participants received a clinically indicated dlsCT scan (Philips, Amsterdam, the Netherlands) and an additional 3 T MRI scan (Philips, Amsterdam, the Netherlands) of the liver and the skeletal muscle within 7 days (median, 0 days; range, 0–7 days).
Computed tomography scans were performed with 120 kV, a dose right index of 16 with boost for the liver (+3), and otherwise identical parameters as for the phantom scans. Image acquisition started 90 seconds after injection of 80 mL Imeron 350 (Bracco Imaging, Konstanz, Germany) with a flow rate of 2 mL/s.
The MRI protocol included a T2-weighted sagittal sequence (TE, 80 milliseconds; TR, 484 milliseconds; FA, 90 degrees) and transverse T1-weighted mDIXON sequences (TE, 1.3/2.3 milliseconds; TR, 3.7 milliseconds; FA, 10 degrees) of the liver and the muscle for anatomic orientation. Furthermore, transverse 3D gradient echo sequences with 20 TEs as used for the phantom scans were acquired of the liver and the muscle for MRR.
Magnetic resonance imaging muscle measurements were performed at the level of the third lumbar vertebra (L3), as single-energy CT body composition measurements of the skeletal muscle are acquired at that level.25 (link)
Computed tomography scans were performed with 120 kV, a dose right index of 16 with boost for the liver (+3), and otherwise identical parameters as for the phantom scans. Image acquisition started 90 seconds after injection of 80 mL Imeron 350 (Bracco Imaging, Konstanz, Germany) with a flow rate of 2 mL/s.
The MRI protocol included a T2-weighted sagittal sequence (TE, 80 milliseconds; TR, 484 milliseconds; FA, 90 degrees) and transverse T1-weighted mDIXON sequences (TE, 1.3/2.3 milliseconds; TR, 3.7 milliseconds; FA, 10 degrees) of the liver and the muscle for anatomic orientation. Furthermore, transverse 3D gradient echo sequences with 20 TEs as used for the phantom scans were acquired of the liver and the muscle for MRR.
Magnetic resonance imaging muscle measurements were performed at the level of the third lumbar vertebra (L3), as single-energy CT body composition measurements of the skeletal muscle are acquired at that level.25 (link)
10
Remote Ischemic Preconditioning for TAVI
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Aortic valves were implanted through the transfemoral approach and under general anesthesia as previously described [9 (link)]. Application of RIPC started with the induction of anesthesia. We performed three cycles of ischemia for five minutes followed by reperfusion for five minutes (Figure 2 ). To induce ischemia, the cuff of a standard blood-pressure-manometer (Boso, Jungingen, Germany) was inflated 20–30 mmHg above the systolic arterial pressure. Efficacy was assessed clinically by pulselessness of radial artery and acrocyanosis followed by reactive hyperemia. The time interval between the end of the RIPC procedure and the start of the TAVI intervention was less than 30 min. Patients of each group received either a self-expandable CoreValve Evolut R (Medtronic, Minneapolis, Minnesota, USA) (n = 44) or a balloon-expandable Sapien XT/Sapien 3 (Edwards Lifesciences Inc., Irvine, CA, USA) (n = 22) valve. We used Imeron 350 (Bracco S.p.A., Milan, Italy) as contrast agent.
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