18F-SynVesT-1 was synthesized using previously described methods [22 (link)]. Participants discontinued all AEDs for at least 24 h before PET scans and fasted for at least 6 h before 18F-FDG injection. Patients were monitored and confirmed to have had no clinically visible seizures within 24 h before PET examinations. Continuous EEG recording was started 2 h before radioligand injection to ensure the lack of seizure and that the radioligands were not administered in a postictal situation [23 (link)]. All patients were scanned first with 18F-FDG and then with 18F-SynVesT-1 at the same time on the following day, while controls had only an 18F-SynVesT-1 PET scan. Static PET images were acquired in three dimensions for 5 min, starting at ~ 60 min after intravenous injection of the radioligands. PET/computed tomography (CT) images were acquired by a Discovery Elite PET/CT scanner (GE Healthcare, Waukesha, USA). The scanning protocol was the same as described previously [24 ].
Discovery elite pet ct scanner
Manufactured by GE Healthcare
Sourced in United States
The Discovery Elite PET/CT scanner is a diagnostic imaging device that combines positron emission tomography (PET) and computed tomography (CT) technologies. It is designed to capture high-quality images of the body's physiological processes and anatomical structures.
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5 protocols using discovery elite pet ct scanner
1
PET Imaging of Synaptic Vesicle Glycoprotein 2A
2
FDG-PET Neuroimaging Protocol for Spatial Normalization
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FDG-PET was acquired using a Discovery Elite PET/CT scanner (GE Healthcare, Chicago, IL, United States) prior to surgical resection. Images were acquired in 3 dimensions over a 60-min time period, following the scanning protocol described by Tang et al. (2018) (link). Images were reconstructed with an ordered subset expectation maximization algorithm with 6 iterations and 6 subset methods. Individual FDG-PET image volumes were spatially normalized into standard stereotactic Montreal Neurological Institute (MNI) space with linear and nonlinear 3D transformations using statistical parametric mapping software (SPM, Wellcome Department of Cognitive Neurology, London, United Kingdom) on MATLAB (MathWorks, Natick, MA, United States). To facilitate comparison across all participants, the intensity of images was globally normalized. After that, the automated anatomical labeling (AAL) (Tzourio-Mazoyer et al., 2002 (link)) atlas was applied to segment the cerebral cortex into 90 regions (45 for each hemisphere without the cerebellum).
3
PET Imaging Protocol for Seizure Studies
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Within 1 week of clinical evaluation, 18F‐FDG‐PET scanning was performed using a Discovery Elite PET/CT scanner (GE Healthcare). Antiseizure medications (ASMs) were discontinued for at least 24 h, and patients fasted for at least 6 h before 18F‐FDG injection. Under strict surveillance, patients had no clinically visible seizures within 24 h and had a continuous EEG recording 2 h before tracer injection to ensure that 18F‐FDG was not implemented in a postictal situation.21 18F‐FDG was injected intravenously through the cubital vein at a dose of 3.7 MBq/kg over 1 min. Static PET/CT images were acquired in three dimensions over 60 min after tracer injection. Participants were laid flat in the PET scanner, which allowed slices to be parallel to the canthomeatal line. The full width of the scan at half maximum was 5.4 mm. The detailed protocol of the PET scan has been described previously.22
4
Standardized 18F-FDG PET/CT Imaging Protocol
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18F-FDG PET/CT image acquisition was performed with Discovery PET/CT Elite scanner (GE Healthcare). After fasting for at least 6 h, patients were intravenously injected with 18F-FDG (3.5 to 4.0 MBq/kg). The weight of the patients was obtained and the fasting blood glucose levels were controlled to less than 150 mg/dl before injection. Patients after injection were advised to rest for 1 h before initiating the PET/CT scan. Patients were placed in a supine position with quiet breathing. CT images were acquired from the skull vertex to proximal thigh initially and then the corresponding PET data were collected. CT data were used for attenuation correction and the standard protocol settings were as follows: 120 KV, 180 mA, slice thickness of 3.75 mm. PET scanning images were acquired in 7 to 8 bed positions and the acquisition time was 3 min per bed position. Image fusion was performed after reconstruction by iterative method.
5
Automated Quantification of Abdominal Fat
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This research used the tomography/computed tomography (PET/CT) examination to obtain CT images. All patients, placed in a supine position with both upper limbs raised above the head, underwent whole-body CT examination using discovery PET / CT elite scanner (GE Healthcare, Milwaukee, Wisconsin, USA) and light speed 128 slice spiral. After the completion of the CT localization image, CT scanning was performed and the corresponding data were collected. The scanning range was from the cranial apex to the middle part of the thigh. CT scanning parameters: 120 kV, 180 mA, rotation time 0.5 s/r, pitch 1.375, layer thickness 3.75 mm, layer spacing 3.25 mm. After scanning, the whole-body CT image was transmitted to GE Advantage workstations (GEAW) 4.5 post-processing workstation, the image was positioned to the level of navel, and the “X-Sect” mode was started to draw the total area along the abdominal skin contour, and then the abdominal area was drawn along the inner edge of abdominal wall muscle tissue, and the fat attenuation range (−190 ~ −30 Hounsfield units) was adjusted. The color part is the fat area (Figure 1 ), and then the post-processing workstation calculates the TFA and VFA. SFA was calculated by subtracting VFA from TFA. VFA, TFA, SFA were computed for each image in cm2.
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