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4 cyano 4 phenylcarbonothioylthio pentanoic acid cpa

Manufactured by Merck Group
Sourced in United States

4-Cyano-4-(phenylcarbonothioylthio)pentanoic acid (CPA) is a chemical compound used as a reagent in various laboratory applications. It serves as a chain transfer agent in controlled radical polymerization reactions. The compound has the molecular formula C15H17NO2S2.

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2 protocols using 4 cyano 4 phenylcarbonothioylthio pentanoic acid cpa

1

Biodegradable Polymer Synthesis and Characterization

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ε-Caprolactone (CL, Acros, 99% purity), 2-ethylhexanoic acid tin(II) salt (Sn(Oct)2; Sigma-Aldrich, St. Louis, MO, USA, purity ≥95%), 4,4′-Azobis(4-cyanovaleric acid) (ACVA; Sigma-Aldrich, purity ≥ 98%), 4-Cyano-4-(phenylcarbonothioylthio)pentanoic acid (CPA; Sigma-Aldrich, purity ≥ 97%), poly(ethylene glycol) methyl ether methacrylate (PEGMA; Sigma-Aldrich, Mn 950 Da), Tween80 (Sigma-Aldrich), Diethyl ether (DEE, Sigma-Aldrich, ≥99%), Deuterated chloroform (CDCl3, Sigma-Aldrich, 99.8%), Ethanol (EtOH, Sigma-Aldrich, 99.8%), acetonitrile (ACN, Sigma-Aldrich, 99.9%), 6-hydroxycaproic acid (HCA, ABCR, Karlsruhe, Germany, 95%) were used as received without further treatments. The cell medium is composed by high glucose DMEM/F12 (Biowest, Nuaillé, France) supplemented with 10% fetal bovine serum (Lonza, Basel, Switzerland). Phosphate-buffered saline solution (PBS) was purchased from Sigma-Aldrich. For gel permeation chromatography (SEC) analysis Tetrahydrofuran (THF, Sigma-Aldrich, purity ≥ 99.7%) was used as eluent.
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2

Polymer-based Biomaterial Synthesis Protocol

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A PEEK sheet (APTIV1000 sheet, 100 mm thick) was obtained from Victrex PLC (Lancashire, UK). MPC and Lipidure s -PMB (water-soluble random PMB) were purchased from NOF Co., Ltd (Tokyo, Japan), which was synthesized using a previously reported procedure. 27 Additionally, 2,2 0 -azobisisobutyronitrile (AIBN) was purchased from Kanto Chemical Co., Inc. (Tokyo, Japan). Ethylene bis(2-bromoisobutyrate) (EBBiB), tris(2pyridylmethyl) amine (TPMA), and 4-cyano-4-(phenylcarbonothioylthio)pentanoic acid (CPA) were purchased from Sigma-Aldrich (St Louis, MO, USA). L-Ascorbic acid, copper(II) bromide (CuBr 2 ), and albumin from bovine serum (BSA, 019-21272) were obtained from Wako Pure Chemical Industries (Osaka, Japan). All reagents were of extra-pure grade and were used without further purification.
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