Stata software version 14 for windows

Statistical analysis was performed using the STATA software version 14 for Windows (Stata Corp., College Station, TX, US). Based on the results of normality tests, continuous variables (i.e., duration of disease, glycemic indices) are presented either as mean±SD, and categorical outcomes (i.e., meeting the preset glycemic targets) are demonstrated as proportions (95% confidence interval [95% CI]) or mean±SEM.

Statistical analysis was performed using the STATA software version 14 for Windows (Stata Corp., College Station, TX, US).
Based on the results of normality tests, continuous variables (i.e. blood pressure, duration of disease, glycemic, and lipid indices) are presented either as mean ± standard deviation (SD)/standard error. Categorical outcomes (i.e. meeting the preset glycemic, blood pressure and lipid control targets) are demonstrated as proportions (95% confidence interval [95% CI]) or mean ± S.E.M. For comparing multivariate sample means, we used Multivariate Analysis of Variance (MANOVA) analysis.

In our study, categorical variables were compared using Pearson's chi-squared tests for. OS was calculated using the Kaplan—Meier method and compared using the log-rank test. We also used cumulative incidence risk to analyze the first events of CNS progression. Other first events of non-CNS progression, death or loss to follow-up beyond progression were analyzed as competing risks. HRs were used in Cox proportional hazard models, and the corresponding 95% CIs were used to compare the OS between the treatment subgroups. The Statistical Package for the Social Sciences for Windows software version 18.0 (SPSS Inc., Chicago, IL, USA) were used for all statistical analyses. OS and cumulative incidence curves were plotted using STATA for Windows software version 14.0 (StataCorp, College station, TX, USA). A two-sided P < 0.05 was considered statistically significant.