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Blood tests included white blood cell (WBC, expressed as /μL, normal range: 3300-8600/μL), hemoglobin (Hb, expressed as g/dL, normal range: 13.7–16.8 g/dL), platelet count (expressed as 10⁴/μL, normal range: 13.1–36.2x10⁴/μL), prothrombin time-international normalized ratio (PT-INR, normal range: 0.90–1.10), activated partial thromboplastin time (APTT, expressed as second (s), normal range: 25.0–40.0 s), fibrinogen (expressed as mg/dL, normal range: 200–400 mg/dL), fibrin degradation products (FDP, expressed as μg/mL, normal range: 0.0–5.0 μg/mL), D-dimer (DD, expressed as μg/mL, normal range: 0.00–1.00 μg/mL) and lactate (expressed as mmol/L, normal range: 0.5–1.6 mmol/L).
WBC, Hb and platelet were measured by the Sysmex XN-9000 (SYSMEX CORPORATION, Kobe, Japan); values of PT-INR, APTT, FDP and DD were obtained by the CP3000 (SEKISUI MEDICAL CO., LTD., Tokyo, Japan); and lactate level was measured by the ABL825 (Radiometer CO., LTD., Tokyo, Japan). The following reagents were used for coagulation tests: PT-INR (Thromborel^® S, Siemens Healthcare Diagnostics Products GmbH, Marburg, Germany), APTT (Coagpia^® APTT-N, SEKISUI MEDICAL CO., LTD., Tokyo, Japan), fibrinogen (Coagpia^® Fbg, SEKISUI MEDICAL CO., LTD., Tokyo, Japan), FDP (Nanopia^® P-FDP, SEKISUI MEDICAL CO., LTD., Tokyo, Japan) and DD (Nanopia^® D-dimer, SEKISUI MEDICAL CO., LTD., Tokyo, Japan).