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Abemaciclib mesylate

Manufactured by Selleck Chemicals
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Sourced in China

Abemaciclib mesylate is a white to light yellow solid compound that is used as a pharmaceutical intermediate. It functions as a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. This compound is utilized in the development and production of various drug products.

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Lab products found in correlation

Ab64883, by Abcam (1 mentions) Fulvestrant, by Selleck Chemicals (1 mentions) Tamoxifen metabolite 4 hydroxytamoxifen 4 oht, by Merck Group (1 mentions) Anti β actin 60008 1 lg, by Proteintech (1 mentions) Normal igg peroxidase conjugated affinipure goat anti rabbit mouse igg h l, by Jackson ImmunoResearch (1 mentions) Palbociclib hcl, by Selleck Chemicals (1 mentions)

2 protocols using abemaciclib mesylate

1

Western Blot Antibody Validation

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Antibodies used in immunoblotting: COL11A1 (ab64883, Abcam, 1:1000 dilution), ERα (No.8644, CST, 1:1000 dilution), anti-β-actin (60008-1-lg, Proteintech, 1:5000 dilution). Normal IgG/Peroxidase-conjugated AffiniPure Goat Anti-Rabbit/Mouse IgG (H + L) was purchased from Jackson Immuno Research. Tamoxifen metabolite 4-hydroxytamoxifen (4-OHT) was purchased from Sigma. Palbociclib HCl (#S1116), abemaciclib mesylate (#S7158), ribociclib HCl (#S5187) and fulvestrant (#S1191) were obtained from Selleck (Shanghai, China).
Fu C., Duan S., Zhou X., Meng Y, & Chen X. (2024). Overexpression of COL11A1 confers tamoxifen resistance in breast cancer. NPJ Breast Cancer, 10, 38.
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2

Abemaciclib Mesylate Protocol

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The CDK4/6 inhibitor abemaciclib mesylate (LY2835219) was purchased from Selleckchem.
Singh A., Pruett N., Pahwa R., Mahajan A.P., Schrump D.S, & Hoang C.D. (2021). MicroRNA-206 suppresses mesothelioma progression via the Ras signaling axis. Molecular Therapy. Nucleic Acids, 24, 669-681.
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