Vereos pet ct scanner

Manufactured by Philips

Sourced in United States

The Vereos PET/CT scanner is a diagnostic imaging device that combines positron emission tomography (PET) and computed tomography (CT) technologies. It is designed to capture high-quality images of the body's internal structures and functions.

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Lab products found in correlation

16 slice gemini tf big bore, by Philips (2 mentions) Digital photon counting, by Philips (1 mentions) Gemini tf big bore, by Philips (1 mentions) Eclipse v15, by Agilent Technologies (1 mentions) Tf big bore, by Philips (1 mentions) Gemini tf, by Philips (1 mentions)

13 protocols using vereos pet ct scanner

FDG-PET Imaging Protocol for EARL Accreditation

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FDG‐PET images were acquired on a Vereos PET/CT scanner (Philips Medical Systems, Best, The Netherlands) using two‐bed positions with an acquisition time of 3 min per bed position. For each repeated scan, the time per bed position was increased to assure similar count statistics for each scan. The scanner was EARL accredited and reconstruction was performed using an EARL‐based reconstruction protocol using a blob‐based 3D iterative reconstruction algorithm (blobTOF; three iterations and 15 subsets) followed by a 5.5 mm full width at half maximum post‐reconstruction Gaussian filter.¹⁷ The image voxel size was 4 × 4 × 4 mm³. A low dose CT scan (40 mAs, 120 kVp) was acquired prior to the PET acquisition for the purpose of attenuation correction.

Kalisvaart G.M., van Velden F.H., Hernández‐Girón I., Meijer K.M., Ghesquiere‐Dierickx L.M., Brink W.M., Webb A., de Geus‐Oei L., Slump C.H., Kuznetsov D.V., Schaart D.R, & Grootjans W. (2022). Design and evaluation of a modular multimodality imaging phantom to simulate heterogeneous uptake and enhancement patterns for radiomic quantification in hybrid imaging: A feasibility study. Medical Physics, 49(5), 3093-3106.

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Synthesis and PET Imaging of [18F]PSMA-1007

Cited 2 times

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[18F]PSMA-1007 had been synthesized according to Cardinale et al. (18 (link)). The mean injected activity of [¹⁸F]PSMA-1007 was 299 MBq (min–max: 249–370 MBq). Patients underwent a whole-body PET scan starting 2 h after injection. Scans were performed with a 16-slice Gemini TF big bore in one patient and a Vereos PET/CT scanner in nine patients (all Philips Healthcare, USA). A phantom study was performed and comparable SUV values were obtained in both systems (19 (link)). Both scanners fulfilled the requirements indicated in the European Association of Nuclear Medicine (EANM) imaging guidelines and obtained EANM Research Ltd (EARL). accreditation during acquisition. At the time of the PET scan, either a contrast-enhanced or native diagnostic CT scan (120 kVp, 100–400 mAs, dose modulation) was performed for attenuation correction (depending on previous CT scans and contraindications). Please see (19 (link)) for details about reconstruction methods. All systems resulted in a PET image with a voxel size of 2 × 2 × 2 mm³. The uptake of [¹⁸F]PSMA-1007 was quantified in terms of standardized uptake values (SUV) normalized body weight.

Spohn S.K., Kramer M., Kiefer S., Bronsert P., Sigle A., Schultze-Seemann W., Jilg C.A., Sprave T., Ceci L., Fassbender T.F., Nicolay N.H., Ruf J., Grosu A.L, & Zamboglou C. (2020). Comparison of Manual and Semi-Automatic [18F]PSMA-1007 PET Based Contouring Techniques for Intraprostatic Tumor Delineation in Patients With Primary Prostate Cancer and Validation With Histopathology as Standard of Reference. Frontiers in Oncology, 10, 600690.

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PennPET Explorer Scanner Prototype

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Measurements were made on the prototype PennPET Explorer, consisting of 3 rings of detectors. The scanner is based on detector tiles of 64 lutetium-yttrium oxyorthosilicate (LYSO) scintillation crystals, currently used in the Philips Vereos PET/CT scanner [27 (link)]. Each tile has an 8 × 8 array of 3.86 × 3.86 × 19-mm³ crystals, coupled to a digital SiPM developed by Philips Digital Photon Counting [28 , 29 ]. A ring measures 76.4 cm in diameter and 22.9 cm axially, consisting of 18 modules of 28 detector tiles in a 4 × 7 array. The PennPET Explorer is scalable, with rings stacked axially to form scanners of various axial lengths (with a 1-cm physical gap between rings). In its prototype version, data readout limitations led to 2 rows of inactive tiles (16 inactive crystals) out of the 7 rows in each ring that created a combined 7.6-cm gap in detector coverage between rings. As we extend the scanner from 3 rings to a 6-ring configuration, we are modifying the tile sensor board firmware so that we can read out all 7 rows of detector tiles in each ring but may initially still be limited to 5 active rows/ring. Data with the PennPET Explorer are acquired as singles events from each ring independently but with alignment in timing to allow coincidence sorting. This allows flexibility in setting the axial acceptance angle post-acquisition, before reconstruction of the data.

Daube-Witherspoon M.E., Viswanath V., Werner M.E, & Karp J.S. (2020). Performance Characteristics of Long Axial Field-of-View PET Scanners with Axial Gaps. IEEE transactions on radiation and plasma medical sciences, 5(3), 322-330.

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Standardized 18F-FDG PET/CT Imaging Protocol

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All scans were acquired on a digital Vereos PET/CT scanner (Philips Healthcare, Best, The Netherlands) according to the most recent European Association for Nuclear Medicine (EANM) procedure guidelines for tumor imaging [18 (link)]. The PET/CT scanner was accredited by the Research4Life (EARL) initiative for quantitative PET/CT imaging. Patients fasted at least 6 h before imaging and were hydrated with 500 mL of water. [¹⁸F]FDG was administered 60 min before the acquisition of the PET scan. A low-dose CT scan (52 mAs, 120 kVp) was acquired prior to PET acquisition for the purpose of attenuation correction and anatomical reference. Standard [¹⁸F]FDG PET/CT scans were acquired from the skull base to mid-thigh or toes depending on the location of the primary tumor. Image acquisition time was 2 min per bed position. Image reconstruction was performed using a blob-based 3D iterative reconstruction algorithm (blobTOF; 3 iterations and 9 subsets) followed by a 5.5 mm full-width at half maximum (FWHM) post-reconstruction Gaussian filter. The image voxel size was 4 × 4 × 4 mm³. After reconstruction, all PET images were expressed in SUV by normalizing voxel radioactivity concentrations [kBq·mL⁻¹] to the injected dose of [¹⁸F]FDG [MBq] and the patient’s body weight (kg).

Kalisvaart G.M., Grootjans W., Bovée J.V., Gelderblom H., van der Hage J.A., van de Sande M.A., van Velden F.H., Bloem J.L, & de Geus-Oei L.F. (2021). Prognostic Value of Quantitative [18F]FDG-PET Features in Patients with Metastases from Soft Tissue Sarcoma. Diagnostics, 11(12), 2271.

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PSMA-1007 PET/CT Imaging Protocol

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Center 1, Freiburg: [¹⁸F] PSMA-1007 had been synthesized according to Cardinale et al. (11 (link)). The patients underwent a whole-body PET scan starting 2 h after injection (median activity in megaBecquerel: 313 MBq, range: 245–454 MBq). The scans were performed with a 64-slice Vereos PET/CT scanner in 61 patients and with a Gemini TF Big Bore in 23 patients (Philips Healthcare, USA). During the PET scan, a contrast-enhanced diagnostic CT scan (120 kVp, 100–400 mAs, dose modulation) was performed. The tracer uptake was quantified using standardized uptake values (SUV) normalized body weight.

Marinescu I.M., Spohn S.K., Kiefer S., Bronsert P., Ceci L., Holzschuh J., Sigle A., Jilg C.A., Rühle A., Sprave T., Nicolay N.H., Winzer R., Rehm J., Kotzerke J., Hölscher T., Grosu A.L., Ruf J., Benndorf M, & Zamboglou C. (2022). Intraindividual Comparison Between [18F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients. Frontiers in Oncology, 12, 880042.

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PET-CT Imaging of Household Contacts and PLHIV

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Household Contacts, PLHIV, and a subset of the Community Controls had PET-CT imaging performed in addition to the routine chest radiographs, according to their study protocol. PET-CT imaging was done at the Nuclear Medicine Research Institute Node for Infection Imaging (NII), Stellenbosch University, South Africa with a Vereos PET-CT scanner (Philips, Amsterdam, Netherlands).^{10 (link)} 18F-fluorodeoxyglucose (FDG) radiotracer was administered at a dose of 2.8 mBq per kg, 60 min before imaging. Results were reported by consensus between a nuclear medicine physician and a radiologist.

Shaw J.A., Meiring M., Allies D., Cruywagen L., Fisher T.L., Kasavan K., Roos K., Botha S.M., MacDonald C., Hiemstra A.M., Simon D., van Rensburg I., Flinn M., Shabangu A., Kuivaniemi H., Tromp G., Malherbe S.T., Walzl G, & du Plessis N. (2023). Optimising the yield from bronchoalveolar lavage on human participants in infectious disease immunology research. Research Square.

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PSMA-HBED-CC Radiolabeling with 68Ga

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The PSMA-HBED-CC radiolabeling with ⁶⁸GaCl₃ was performed according to good laboratory practice using a fully automated synthesis module (Ecker & Ziegler, Germany) and sterile single-use cassettes. The decay-corrected yield was > 95%, and radiochemical purity of the final product was ≥ 97%. The mean injected activity of ⁶⁸Ga-HBED-CC-PSMA was 205.4 MBq (95% CI 200.1–210.7 MBq). Patients underwent a whole-body PET scan starting 1 h after injection. Scans were performed with either a 64-slice Gemini TF PET/CT scanner, a 16-slice Gemini TF big bore, or Vereos PET/CT scanner (all Philips Healthcare, USA). Cross-calibration of the three scanners was performed to ensure comparability of the quantitative measurements. At the time of the PET scan, either a contrast-enhanced diagnostic CT scan (120 kVp, 100–400 mAs, dose modulation) or a low-dose CT scan (120 kVp, 25 mAs) was performed for attenuation correction (depending on previous CT scans and contraindications). The uptake of ⁶⁸Ga-PSMA was quantified in terms of standardized uptake values (SUV) normalized body weight.

Spohn S., Jaegle C., Fassbender T.F., Sprave T., Gkika E., Nicolay N.H., Bock M., Ruf J., Benndorf M., Gratzke C., Grosu A.L, & Zamboglou C. (2020). Intraindividual comparison between 68Ga-PSMA-PET/CT and mpMRI for intraprostatic tumor delineation in patients with primary prostate cancer: a retrospective analysis in 101 patients. European Journal of Nuclear Medicine and Molecular Imaging, 47(12), 2796-2803.

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PSMA-1007 PET/CT Protocol for Prostate Cancer Imaging

Cited 2 times

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[¹⁸F]PSMA-1007 had been synthesized according to Cardinale et al.^{22 (link)}. The mean injected activity of [¹⁸F]PSMA-1007 was 310 MBq (min–max: 249–370 MBq). Patients underwent a whole-body PET scan starting 2 h after injection. Scans were performed with a 64-slice Vereos PET/CT scanner in all 10 patients (Philips Healthcare, USA). At the time of the PET scan, a contrast-enhanced diagnostic CT scan (120 kVp, 100–400 mAs, dose modulation) was performed for attenuation correction. The uptake of [¹⁸F]PSMA-1007 was quantified in terms of standardized uptake values (SUV) normalized body weight.
Two radiation oncologists with 6 (CZ) and 2 years (SS) experience in interpretation of PSMA-PET images, respectively, contoured GTV-PET in consensus by applying SUVmin–max 0–10^{23 (link)} in Eclipse v15.1 software (Varian Medical Systems, USA). The presence of PCa on PET images was defined as mono- or multifocal uptake greater than adjacent background in more than one slice (GTV-PET). Apart from PET and CT images for anatomical orientation, no additional clinical information was provided. The prostate volume on CT was delineated by an experienced reader (CZ).

Zamboglou C., Kramer M., Kiefer S., Bronsert P., Ceci L., Sigle A., Schultze-Seemann W., Jilg C.A., Sprave T., Fassbender T.F., Nicolay N.H., Ruf J., Benndorf M., Grosu A.L, & Spohn S.K. (2021). The impact of the co-registration technique and analysis methodology in comparison studies between advanced imaging modalities and whole-mount-histology reference in primary prostate cancer. Scientific Reports, 11, 5836.

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PET/CT Imaging for Surgical Guidance

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All patients underwent [¹⁸F]FDG PET/CT before surgery or biopsy. A PHILIPS GEMINI GXL16 PET/CT scanner and PHILIPS VEREOS PET/CT scanner were used. Patients fasted for at least 6 h before injection with 3.70–5.55 MBq/kg [¹⁸F]FDG, and PET/CT acquisition was performed 60 ± 5 min after the injection. The fasting blood glucose concentration was controlled below 11.1 mmol/L. The body scanning range was from the skull base to the upper femur. The CT data were used to correct the attenuation of the PET image, and the corrected PET image was fused with the CT image.

Zhao X., Zhao Y., Zhang J., Zhang Z., Liu L, & Zhao X. (2023). Predicting PD-L1 expression status in patients with non-small cell lung cancer using [18F]FDG PET/CT radiomics. EJNMMI Research, 13, 4.

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PET-CT Imaging of Household Contacts

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Household Contacts, PLHIV, and a subset of the Community Controls had PET-CT imaging performed in addition to the routine chest radiographs, according to their study protocol. PET-CT imaging was done at the Nuclear Medicine Research Institute Node for Infection Imaging (NII), Stellenbosch University, South Africa with a Vereos PET-CT scanner (Philips, Amsterdam, Netherlands)^{10 (link)}. 18F-fluorodeoxyglucose (FDG) radiotracer was administered at a dose of 2.8 mBq per kg, 60 min before imaging. Results were reported by consensus between a nuclear medicine physician and a radiologist.

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