All mouse experiments were approved by the MSKCC and/or CSHL Internal Animal Care and Use Committee (animal protocol 11-06-011 at MSKCC and 21-4 at CSHL). All relevant animal use guidelines and ethical regulations were followed. Mice were maintained under specific pathogen-free conditions. Housing was on a 12-h–12-h light–dark cycle under standard temperature and humidity of approximately 18–24 °C and 40–60%, respectively. The following mice were used: 3- to 4-month-old C57BL/6 mice (purchased from Charles River), 18-month-old C57BL/6 mice (obtained from the National Institute of Aging) and 6-week-old B6.SJL-Ptrca/BoyAiTac (CD45.1) mice (purchased from Taconic). Mice of both sexes were used at 8–12 weeks of age and 18–20 months of age for the aging experiments, males of 8–12 weeks old for the HFD experiments and females of 6–10 weeks old for T cell isolation. Mice were kept in group housing. Mice had free access to food and water except during the starvation period before glucose or insulin tolerance testing. Aging mice were fed a normal diet (PicoLab Rodent Diet 20, LabDiet), mice on the HFD experiments were fed an HFD (TD.06414, 60% of kcal from fat; Envigo).
B6 sjl ptrca boyaitac cd45.1 mice
Manufactured by Taconic Biosciences
B6.SJL-Ptrca/BoyAiTac (CD45.1 mice) are a strain of laboratory mice that express the CD45.1 allele. The CD45 protein is a receptor-linked protein tyrosine phosphatase that is important for the development and activation of T and B lymphocytes. The CD45.1 allele is a genetic marker that can be used to distinguish these mice from other strains that express the CD45.2 allele.
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4 protocols using b6 sjl ptrca boyaitac cd45.1 mice
1
Aging and High-Fat Diet Mice Studies
2
Mouse Experiments for Cancer Research
3
Aging and Diet Experiment Protocols
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All mouse experiments were approved by the MSKCC and/or CSHL Internal Animal Care and Use Committee. All relevant animal use guidelines and ethical regulations were followed. Mice were maintained under specific pathogen-free conditions. The following mice were used: 3- to 4-month-old C57BL/6 mice (purchased from Charles River), 18-month-old C57BL/6 mice (obtained from the National Institute of Aging), and 6-week-old B6.SJL-Ptrca/BoyAiTac (CD45.1 mice) (purchased from Taconic). Mice of both sexes were used at 8–12 weeks of age and 18–20 months of age for the aging experiment, males of 8–12 weeks for the high fat diet experiments and females of 6–10 weeks old for T cell isolation. Mice were kept in group housing. Mice had free access to food and water except during the starvation period before glucose or insulin tolerance testing. Aging mice were fed a normal diet (PicoLab Rodent Diet 20, LabDiet), mice on the high fat diet (HFD) experiments were fed a HFD (TD.06414, 60% of kcal from fat; Envigo). Mice were randomly assigned to the experimental groups.
4
Mouse Experiments for Cancer Research
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All mouse experiments were approved by the Memorial Sloan Kettering Cancer Center (MSKCC) Internal Animal Care and Use Committee. All relevant animal use guidelines and ethical regulations were followed. Mice were maintained under specific pathogen-free conditions, and food and water were provided ad libitum. The following mice were used: C57BL/6N background, NOD-scid IL2Rgnull (NSG) mice (purchased from The Jackson laboratory) and B6.SJL-Ptrca/BoyAiTac (CD45.1 mice) (purchased from Taconic). Mice were female and/or male and were used at 8–12 weeks of age (5–7 weeks old for the xenograft experiments and 6–10 weeks old for T cell isolation) and were kept in group housing. Mice were randomly assigned to the experimental groups.
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