Aldh1a3 antibody

Manufactured by Abcam

ALDH1A3 antibody is a primary antibody that recognizes the ALDH1A3 protein, which is a member of the aldehyde dehydrogenase family. ALDH1A3 is involved in the oxidation of retinal to retinoic acid, a crucial process in the metabolism of vitamin A.

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Lab products found in correlation

Sox2 antibody, by Abcam (1 mentions) Cd44 antibody, by Abcam (1 mentions)

2 protocols using aldh1a3 antibody

Immunohistochemical and Immunofluorescent Analysis of Paraffin-Embedded Tissues

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Paraffin-embedded tissues with complete clinical information were obtained from CGGA Tissue Bank. This study was approved by the institutional review boards, and written informed consent was obtained from each patient. Antibodies for immunohistochemical staining were ALDH1A3 antibody (1:100, Abcam), CD44 antibody (1:100, Cell signal), andSOX2 antibody (1:100, Abcam). Antibodies for immunofluorescent staining were ALDH1A3 antibody (1:100, Abcam), CD44 antibody (1:1000, Cell signal), and SOX2 antibody (1:200, Abcam).

Li G., Li Y., Liu X., Wang Z., Zhang C., Wu F., Jiang H., Zhang W., Bao Z., Wang Y., Cai J., Zhao L., Kahlert U.D., Jiang T, & Zhang W. (2018). ALDH1A3 induces mesenchymal differentiation and serves as a predictor for survival in glioblastoma. Cell Death & Disease, 9(12), 1190.

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ALDH1A3 Expression in NSCLC Tissues

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Formalin-fixed and paraffin-embedded (FFPE) tissues from clinically annotated, surgically resected lung cancer specimens were obtained from the Lung Cancer Specialized Program of Research Excellence (SPORE) Tissue Bank at MD Anderson Cancer Center used to construct NSCLC tissue microarray (TMA). Tissue sections (5 μm) were stained with ALDH1A3 antibody (1:100, Abcam) and assigned expression scores. NSCLCs were dichotomized into ALDH1A3 high and low expression classes on the basis of its median expression scores.

Shao C., Sullivan J.P., Girard L., Augustyn A., Yenerall P., Rodriguez J., Liu H., Behrens C., Shay J.W., Wistuba I.I, & Minna J.D. (2014). Essential role of aldehyde dehydrogenase 1A3 (ALDH1A3) for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway. Clinical cancer research : an official journal of the American Association for Cancer Research, 20(15), 4154-4166.

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