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5 4 phenoxybutoxy psoralen pap 1

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5-(4-Phenoxybutoxy) psoralen (PAP-1) is a laboratory compound. It has the chemical formula C20H20O4. PAP-1 is a psoralen derivative.

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Lab products found in correlation

Staurosporine, by Merck Group (1 mentions) Clofazimine, by Merck Group (1 mentions) Margatoxin, by Merck Group (1 mentions) F ara a, by Merck Group (1 mentions)

Spelling variants of this product

Psoralen (26 citations) PAP-1 (4 citations)

3 protocols using 5 4 phenoxybutoxy psoralen pap 1

1

Photosensitive Compound Solubilization Protocol

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All membrane-permeant substances were protected from UV sources to prevent their photo-oxidation. Psoralen, 5-(4-Phenoxybutoxy) psoralen (PAP-1; Merck-Sigma-Aldrich, Germany), PAPTP, PCARBTP, clofazimine (Merck-Sigma-Aldrich, Germany) were dissolved in dimethyl sulfoxide (DMSO). Staurosporine (Merck-Sigma-Aldrich, Germany) was dissolved in absolute ethanol (EtOH), and diluted in DMEM. The final concentration of DMSO was ≤0.5% in all assays.
Peruzzo R., Mattarei A., Romio M., Paradisi C., Zoratti M., Szabò I, & Leanza L. (2017). Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells. Frontiers in Oncology, 7, 239.
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2

Vascular Smooth Muscle Cell Serum Response

Cited 1 time
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Primary HASMC were obtained from Innoprot (Derio, Spain) and cultured as described.10 (link) Confluent cells were treated with medium supplemented with 20% of control or uremic human serum for the indicated period of time. When applicable, the Kv1.3-specific inhibitors 5-(4-phenoxybutoxy) psoralen (PAP-1, Sigma-Aldrich) and margatoxin (MgTx) were used at 100 nM22 (link),23 (link) and 10 nM,24 (link) respectively. All experiments were performed using cells between Passages 3 and 5.
Cazaña-Pérez V., Cidad P., Navarro-González J.F., Rojo-Mencía J., Jaisser F., López-López J.R., Alvarez de la Rosa D., Giraldez T, & Pérez-García M.T. (2020). Kv1.3 Channel Inhibition Limits Uremia-Induced Calcification in Mouse and Human Vascular Smooth Muscle. Function, 2(1), zqaa036.
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3

Preparation of KV1.3 Inhibitor Solutions

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F-ara-A (Sigma–Aldrich) was dissolved in DMSO to yield stock solution of 35 mM from which further dilutions in the patch-clamp external solution were made. The KV1.3 selective inhibitor 5-(4-phenoxybutoxy)psoralen (PAP-1; Sigma–Aldrich) was dissolved in DMSO to yield stock solution of 1 mM from which further dilutions in the patch-clamp external solution were made.
de la Cruz A., Vera-Zambrano A., Peraza D.A., Valenzuela C., Zapata J.M., Perez-Chacon G, & Gonzalez T. (2017). Fludarabine Inhibits KV1.3 Currents in Human B Lymphocytes. Frontiers in Pharmacology, 8, 177.
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