Lyso-7, [(5Z)-5-[5-bromo-1H-indol-3-yl)methylene]-3-(4-chlorobenzyl)-thiazolidine-2,4-dione] (CAS Number 1505484-42-3) (CAS Registry Number 1505484-42-3), Mw 447.73 g/mol, was synthesized, purified and characterized by Prof Ivan da Rocha Pitta as reported [11 (link)]. PLA polymer, a poly-rac-lactide Mn 75,000–120,000 g/mol, poloxamer 188, polysorbate 80, polyethylene glycol 300 (PEG 300), glucose, ethanol and methanol (HPLC grade) were purchased from Sigma-Aldrich (Cotia, Brazil). Symplicity® System (Millipore, Bedford, MA, USA) produced Milli-Q water to prepare all solutions throughout the experiments. Soy lecithin with 75% of phosphatidylcholine (Epikuron® 170) was a generous gift from Lucas Meyer (Champlan, France). Sasol Olefins & Surfactants GmbH (Hamburg, Germany) provided Miglyol 810 N. Tedia (Rio de Janeiro, Brazil) provided ethyl acetate, acetone, N,N-dimethylacetamide (DMA), acetone and dimethylsulfoxide (DMSO) (analytical grade).
Symplicity system
Manufactured by Merck Group
Sourced in United States
The Symplicity® System is a laboratory equipment product developed by Merck Group. It is designed to provide a controlled and automated environment for various experimental procedures. The core function of the Symplicity® System is to facilitate precise and consistent sample handling and processing.
Automatically generated - may contain errors
Lab products found in correlation
Poloxamer 188, by Merck Group (3 mentions)
Polysorbate 80, by Merck Group (1 mentions)
Pla polymer, by Merck Group (1 mentions)
Hplc grade, by Merck Group (1 mentions)
Ethanol, by Merck Group (1 mentions)
Methanol, by Merck Group (1 mentions)
Poly ε caprolactone, by Merck Group (1 mentions)
α tocopherol, by Merck Group (1 mentions)
Hydrogen peroxide h2o2, by Merck Group (1 mentions)
Acetone, by Mallinckrodt (1 mentions)
Polyethylene glycol 300, by Merck Group (1 mentions)
Dimethyl sulfoxide (dmso), by Tedia (1 mentions)
Hplc grade methanol, by Merck Group (1 mentions)
Tween 80, by Merck Group (1 mentions)
Ethyl acetate, by Tedia (1 mentions)
3 protocols using symplicity system
1
Synthesis and Characterization of Lyso-7 Compound
2
Nanocarriers for Targeted Delivery
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All reagents for culture cells were obtained from Life Technologies SARL (Cergy Pontoise Cedex, France). Epikuron® 170 (~70 % soy phosphatidylcholine) was a gift from Lucas Meyer (Le Blanc Mesnil, France). Miglyol® 810 N oil (capryc/caprylic triglyceride) was purchased from Hülls (Frankfurt, Germany). The poly-ε-caprolactone (PεCL, average 42,500 Da), Poloxamer®188, DHA, α-tocopherol (vitamin E) and hydrogen peroxide (H2O2) were provided by Sigma-Aldrich (St. Louis, MO) and the acetone was purchased from Mallinckrodt chemicals (USA). Symplicity® System (Millipore, Bedford, USA) was used to produce Milli-Q water (18.2 MΩ), which was used to prepare nanocapsules and all solutions for this study. The synthesis of 4(RS)-4F4t-neuroprostane was performed according to our published procedure [47 ].
3
Synthesis and Characterization of Lyso-7 Compound
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Lyso-7, [(5Z)-5-[5-bromo-1H-indol-3-yl)methylene]-3-(4-chlorobenzyl)-thiazolidine-2,4-dione] (CAS Registry Number 1505484-42-3) (1), Mw 447.73 g/mol, log p = 5.642 (calculated by ACD/Lab software V11.02©) was synthesized, purified and provided by Prof. Ivan da Rocha Pitta (UFPE), as recently reported [10, 11] . Benznidazole (BZ) (N-benzyl-(2-nitro-1H-imidazol-1-yl), Mw 260.25 g/mol, purity 99.85% (2) (Fig. 1), Poloxamer ® 188 and polymer poly-rac-lactide (PLA), Mn 75,000-120,000 g/mol, Tween ® 80, Polyethylene glycol 300 and methanol (HPLC grade) were purchased from Sigma-Aldrich (Brazil). Symplicity ® System (Millipore, Bedford, USA) was used to produce Milli-Q water, which was used to prepare all solutions throughout the experiments. Soy lecithin (Epikuron ® 170) was provided by Lucas Meyer (France) as a kind gift. Mygliol 810 N was provided by Hulls (Germany). Ethyl acetate, N,N-dimethylacetamide (DMA) and dimethylsulfoxide (DMSO) (analytical grade) were provided by Tedia (Rio de Janeiro, Brazil).
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