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Lorglumide

Manufactured by Merck Group
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Sourced in United States, Sao Tome and Principe

Lorglumide is a laboratory equipment product manufactured by Merck Group. It is a chemical compound used in research and scientific experimentation. The core function of Lorglumide is to serve as a tool for researchers and scientists in their investigations, without making any claims about its intended use or applications.

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Lab products found in correlation

Dipeptide library, by AnaSpec (1 mentions) Cck 8, by Merck Group (1 mentions) High performance liquid chromatography (hplc), by Shimadzu (1 mentions) Dexamethasone (dex), by Merck Group (1 mentions) Haloperidol, by Merck Group (1 mentions) Tricaine, by Merck Group (1 mentions) Sincalide, by Merck Group (1 mentions) Devazepide, by Bio-Techne (1 mentions) Cabergoline, by Merck Group (1 mentions)

3 protocols using lorglumide

1

Dipeptide Library Evaluation for Biological Activity

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The dipeptide library was purchased from Anaspec (California, USA). Ser-Tyr (SY) was purchased from BACHEM AG (Bubendorf, Switzerland). Asn-Ala was purchased from RS synthesis (Louisville, KY, USA). Indometacin, a cyclooxygenase (COX) inhibitor, was purchased from Wako Pure Chemical Industries, Ltd. (Osaka, Japan). NG-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, was obtained from Nacalai Tesque, Inc. (Kyoto, Japan). Lorglumide, an antagonist of the cholecystokinin1 CCK1 receptor, was from Sigma-Aldrich Co. (St. Louis, MO, USA).
Koyama D., Sun X., Sasai M., Matsumura S., Inoue K, & Ohinata K. (2019). Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms. Aging (Albany NY), 11(21), 9492-9499.
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2

High-Purity Rb1 Extraction from Ginseng

Cited 1 time
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Rb1 purified from ginseng roots by High-performance liquid chromatography (HPLC) was purchased from Jilin University in China. High-performance liquid chromatography (Shimadzu, Kyoto, Japan) analysis was performed in our laboratory and confirmed that the Rb1 had a purity of ≥ 98% using an Rb1 standard obtained from LKT laboratories (St. Paul, MN) [2 (link)]. CCK-8, Lorglumide and other chemicals were purchased from Sigma (St. Louis, MO).
Shen L., Wang D.Q., Lo C.C., Arnold M., Tso P., Woods S.C, & Liu M. (2015). Gut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats. Physiology & behavior, 152(0 0), 62-67.
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3

Zebrafish Model of Intestinal Inflammation

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Animal research was conducted with approval from The University of Auckland Animal Ethics Committee. Zebrafish larvae were anaesthetized with 120 µg/mL tricaine (Sigma-Aldrich) prior to mounting for imaging.
Zebrafish embryos were obtained from natural spawnings and raised at 28.5° in E3 embryo medium supplemented with methylene blue until 1 dpf. E3 used after 1 dpf did not contain methylene blue, which has antimicrobial activity. Induction of enterocolitis by DSS or TNBS exposure was carried out essentially as previously described [20 (link)]. All analyses were performed at 6 dpf unless otherwise noted. Dexamethasone (Sigma-Aldrich), devazepide (Tocris Biosciences) and haloperidol (Sigma-Aldrich) were dissolved in dimethyl sulfoxide (DMSO). Cabergoline (Sigma-Aldrich) was dissolved in ethanol. Lorglumide and sincalide (Sigma-Aldrich) were dissolved in water.
Oehlers S.H., Flores M.V., Hall C.J., Wang L., Ko D.C., Crosier K.E, & Crosier P.S. (2017). A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation. The FEBS journal, 284(3), 402-413.
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