Hardness of the tablet, which is the force applied across the diameter of the tablet to break a tablet into halves, was measured using a Pfizer tablet hardness tester. Tablet's friability was measured using Roche friabilator (USP) at 25 rpm for 4 min[12 ].
Tablet hardness tester
Manufactured by Pfizer
The Tablet Hardness Tester is a device used to measure the physical strength and integrity of solid oral dosage forms, such as tablets and capsules. It assesses the force required to break or fracture the sample, providing data on the tablet's mechanical properties. This information is crucial in evaluating the quality and consistency of pharmaceutical products during the manufacturing process.
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Lab products found in correlation
3 protocols using tablet hardness tester
1
Tablet Hardness and Friability Evaluation
2
Tablet Hardness Evaluation of Enteric-Coated ASA
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Each tablet was solely kept between the jaws Pfizer tablet hardness tester and pushed till it infatuates, and the mean was recorded.
As the ASA tablets were enteric-coated, no need to perform the friability test.
As the ASA tablets were enteric-coated, no need to perform the friability test.
3
Tablet Hardness and Friability Test
Check if the same lab product or an alternative is used in the 5 most similar protocols
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The tablets were pressed between the two poles of the Pfizer tablet hardness tester. The force to break the tablets was recorded thrice. Surface attrition may transpire while tablet handling can be illuminated by Roche Friabilator. 10 tablets weighed (W initial ), positioned, and allowed to fall from a height of 6 inches for 4 min at 25 rpm, later the final weight of tablets (W final ) was taken. The weight loss of tablets was assessed as follows.
Calibration curve 100 mg of LCD dissolved in pH 1.2 solution (0.1M HCl). A series of dilutions (2, 4, 6, 8, and 10 µg/ml) were prepared scanned spectrophotometrically at 239 nm then the absorbance versus concentrations gives a calibration curve.
Calibration curve 100 mg of LCD dissolved in pH 1.2 solution (0.1M HCl). A series of dilutions (2, 4, 6, 8, and 10 µg/ml) were prepared scanned spectrophotometrically at 239 nm then the absorbance versus concentrations gives a calibration curve.
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