The reagents used for the synthesis of ionophores Mg1–Mg5 included 1,10-diaza-18-crown-6 (Synthon); BOP-Cl, diethyl methylmalonate, diethyl n-butylmalonate, adamantylamine, n-octadecylamine, n-dodecylamine, triethylamine, thionyl chloride (Sigma-Aldrich) and other typical reagents and solvents.
The reaction progress and purity of products were monitored by TLC using aluminum sheets covered with silica gel 60F254 (Merck, Kenilworth, NJ, USA). Reaction mixtures were separated using classical column (silica gel 60, 0.063–0.200 mm, Merck). Reagent grade solvents were used.
1H NMR spectra were recorded on Varian INOVA 500 spectrometer at 500 MHz. Chemical shifts are reported in δ (ppm) units. FTIR spectra (film and KBr pellet) were taken on a Nicolet iS10 apparatus. ESI mass spectra were taken on SYNAPT G2-S HDMS (Waters, Milford, MA, USA) spectrometer using a TOF mass analyzer.
RP-18 F254S 0.25 mm modified silica gel reverse phase TLC plates (20 × 20 cm) from Merck were used for the determination of ionophore lipophilicity.
Plasticizers with known lipophilicity, namely o-NPOE, DOS, and BBPA (Sigma-Aldrich, St. Louis, MO, USA), were used as reference.
The reaction progress and purity of products were monitored by TLC using aluminum sheets covered with silica gel 60F254 (Merck, Kenilworth, NJ, USA). Reaction mixtures were separated using classical column (silica gel 60, 0.063–0.200 mm, Merck). Reagent grade solvents were used.
1H NMR spectra were recorded on Varian INOVA 500 spectrometer at 500 MHz. Chemical shifts are reported in δ (ppm) units. FTIR spectra (film and KBr pellet) were taken on a Nicolet iS10 apparatus. ESI mass spectra were taken on SYNAPT G2-S HDMS (Waters, Milford, MA, USA) spectrometer using a TOF mass analyzer.
RP-18 F254S 0.25 mm modified silica gel reverse phase TLC plates (20 × 20 cm) from Merck were used for the determination of ionophore lipophilicity.
Plasticizers with known lipophilicity, namely o-NPOE, DOS, and BBPA (Sigma-Aldrich, St. Louis, MO, USA), were used as reference.