The in vitro MRI experiments of the USL with different concentrations were performed using an MRI scanner (3.0 T, uMR 780, United Imaging). USL with Gd concentrations ranging from 2–22 × 10−6 m was dispersed in water. The in vitro T1‐weighed MRI was performed with the following scan parameters: slice thickness = 1.0 mm, TE = 277.2 ms, TR 2000 ms; bandwidth, 520 Hz Px−1. In vivo MRI was performed using 3.0 T magnetic resonance imaging (uMR 780, United Imaging). When the tumor size approached ≈100 mm3, tumor‐bearing mice were administrated USL via intravenous injection (5 mg kg−1), and the MRI was obtained at the time point of 15 min after the injection. Parameter settings: TR = 2000, TE = 277.2.
Umr 780
Manufactured by United Imaging
Sourced in China
The UMR 780 is a magnetic resonance imaging (MRI) system designed for research applications. It provides high-quality imaging capabilities for advanced medical research. The core function of the UMR 780 is to enable non-invasive, high-resolution imaging of anatomical structures and physiological processes.
Automatically generated - may contain errors
14 protocols using umr 780
1
In Vivo and In Vitro MRI Evaluation of USL
2
Carotid Artery Stenosis Assessment
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The degree of stenosis of the patient’s carotid artery was calculated according to the MRC European Carotid Surgery Trial (ECST) method based on the patient’s CTA images. The 100 patients were categorized into five groups according to the degree of stenosis: group A (stenosis rate 60–70%), group B (stenosis rate 70–80%), group C (stenosis rate 80–90%), group D (stenosis rate 90–95%), and group E (stenosis rate 95–99%, nearly occluded).
All participants underwent carotid vessel wall MRI on a 3.0-T MR scanner (uMR780, United Imaging Healthcare, Shanghai, China) with an 8-channel dedicated carotid coil. The specific magnetic resonance imaging scheme has been described in previous studies [15 (link)].
Carotid plaque traits (including morphological features and compositional features) represented by the images in the four sequences above were interpreted using Vascular Explorer 2 software (TSimaging Healthcare, Beijing, China). The exact method of manually outlining the boundaries of the lumen, wall, and plaque components at each axial MR image of the carotid artery has been described in previous studies [15 (link)].
All participants underwent carotid vessel wall MRI on a 3.0-T MR scanner (uMR780, United Imaging Healthcare, Shanghai, China) with an 8-channel dedicated carotid coil. The specific magnetic resonance imaging scheme has been described in previous studies [15 (link)].
Carotid plaque traits (including morphological features and compositional features) represented by the images in the four sequences above were interpreted using Vascular Explorer 2 software (TSimaging Healthcare, Beijing, China). The exact method of manually outlining the boundaries of the lumen, wall, and plaque components at each axial MR image of the carotid artery has been described in previous studies [15 (link)].
3
Comprehensive 3T MRI Examination Protocol
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All the MRI examinations were performed on a 3.0T MR scanner (uMR 780, United Imaging Healthcare, Shanghai, China) with a commercial 12-channel body phased array coil. MR sequences included: 1) axial T1-weighted (T1W) fast spin echo (FSE) sequence; 2) axial T2-weighted (T2W) FSE sequence; 3) coronal fat-suppressed T2W FSE sequence; 4) sagittal T2W FSE sequence; and 5) diffusion-weighted imaging with a series of b-value 0, 20, 40, 80, 160, 200, 500, 1,000, and 2,000 s/mm2. Table 1
4
Comprehensive 3T MRI Protocol for Research
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All the MR examinations were performed with a commercial 3T MR scanner (uMR 780; United Imaging Healthcare, Shanghai, China) with a 12-channel body coil. Clinical routine MR protocols contained a T2-weighted (T2W) fast spin echo (FSE) sequence, a T1-weighted (T1W) 3D gradient echo (GRE) sequence, a T1W dual-echo (in and out phase) 3D GRE sequence, an echo planar imaging (EPI) based spin echo sequence for diffusion weighted imaging (DWI). For SWI, a 2D breath-hold GRE sequence was utilized. The detailed parameters of above MR sequences were shown in Table 1 .
5
Free-Breathing Lung MRI Acquisition
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Pulmonary free-breathing 1H MRI images were acquired from all subjects using a 3-T scanner (uMR 780, United Imaging Healthcare) in head-first supine position. One coronal slice at the middle of lungs was acquired using a chest coil. The acquisitions were performed during free tidal breathing using a spoiled gradient echo sequence over a period of 85 s at a temporal resolution of 0.441 s (total 192 time-series 1H MRI images for each subject). The sequence settings were field of view 50 × 50 cm2, matrix size 256 × 256, slice thickness 15 mm, echo time 1.04 ms, repetition time 3 ms, flip angle 5°, and bandwidth 384 kHz (1500 Hz/pixel × 256 pixel).
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Accelerated Lumbar MRI Protocol Evaluation
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All lumbar MRI examinations were performed on a 3T scanner (uMR780, United Imaging Healthcare, Shanghai, China). The lumbar were examined with 2D ACS accelerated sequences and 2D traditional sequences for all patients and normal healthy subjects, respectively. Acquisitions included sagittal T2WI, T1WI, Fat Suppression in T2-Weighted (T2-fs) and axial T2WI sequences. The acquisition time of ACS accelerated sequences was 7 min 40s in total, which was shortened compared with 9 min 27s for routine sequence. The specific parameters of these sequences are listed in Table 2 .
MRI Acquisition Parameters for ACS Accelerated Sequences and Routine 2D Sequences
| 2D ACS accelerated Sequences | Routine 2D Sequences | |||||||
|---|---|---|---|---|---|---|---|---|
| Sagittal T1 | Sagittal T2 | Sagittal T2-fs | Axial T2 | Sagittal T1 | Sagittal T2 | Sagittal T2-fs | Axial T2 | |
| 11.98 | 119.4 | 91.14 | 109.44 | 11.98 | 108.54 | 91.14 | 107.04 | |
| 638 | 2000 | 3000 | 3721 | 550 | 2600 | 2500 | 2500 | |
| 11 | 11 | 11 | 3 | 11 | 11 | 11 | 3 | |
| 4 | 4 | 4 | 3.5 | 4 | 4 | 4 | 3.5 | |
| 20 | 10 | 20 | 10 | 20 | 20 | 20 | 10 | |
| 200 | 200 | 200 | 220 | 200 | 200 | 200 | 220 | |
| 300 | 340 | 300 | 280 | 300 | 300 | 300 | 180 | |
| 256 | 240 | 224 | 320 | 256 | 272 | 224 | 320 | |
| 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | |
| 0.78*0.78*4.00 | 0.83*0.83*4.00 | 0.89*0.89*4.00 | 0.69*0.69*3.50 | 0.78*0.78*4.00 | 0.74*0.74*4.00 | 0.89*0.89*4.00 | 0.69*0.69*3.50 | |
7
MRI Lesion Assessment in TBI
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Seven days after TBI, A 3T small-animal Magnetic Resonance Imaging (MRI) scanner (UMR780, United imaging, China) was used to generate series of brain images. T2-weighted imaging (T2) was performed to assess total lesion volume. The setup parameters were as follows: repetition time (TR) = 1,000 ms, echo time (TE) = 110.5 ms, field of view (FOV) = 90 × 90 mm2, image matrix = 336 × 446, and 0.7-mm slice thickness. Image J (Version 1.53C, Maryland, MD, United States) was used to calculate the lesion volume in each brain.
8
Standardized 3T MRI Protocol for Gastrointestinal Imaging
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All examinations are performed on one of four 3.0 T MR scanners (GE Discovery 750HD, GE Healthcare; Siemens MAGNETOM Skyra (2 sets), Siemens AG; uMR 780, United Imaging Healthcare). All patients underwent pre-scan preparation as recommended by the European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and European Society of Pediatric Radiology (ESPR) [17 (link)]; that is, fasting for 4–6 h before the scan and drinking 1000–1500 mL of 2.5% aqueous mannitol solution regularly within 30–45 min before the scan. To minimize bowel peristalsis, 10 mg anisodamine was orally administered 30 min before the examination to patients without contraindications, including glaucoma and prostatic hypertrophy. Additionally, routine MRE sequences were consistent with those suggested by ESGAR/ESPR, as shown in the Additional file 1 : Table S1.
9
3D Fast Spin-Echo MRI Imaging Protocol
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All MRVWI images were acquired using a T1-weighted 3D-variable flip-angle fast spin-echo (FSE) sequence, namely MATRIX (Modulated flip Angle Technique in Refocused Imaging with extended echo train) on a 3T whole-body MR system (uMR780, United Imaging Healthcare Co., Ltd., Shanghai, China). The imaging parameters were as follows: sagittal imaging orientation, repetition time (TR)/echo time (TE) = 800/13.92 ms, field of view = 230 mm × 192 mm × 154 mm, matrix size = 384 × 320 × 256, spatial resolution = 0.6 mm × 0.6 mm × 0.6 mm without interpolation, echo train length = 46, receiver bandwidth = 600 Hz/pixel, compress sensing-based acceleration rate (uCS) = 5.2, scan time = 4 min and 49 s. The study was approved by the local institutional review board, and informed consent was waived for the retrospective study.
10
Multimodal MRI Protocol for Brain Imaging
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All local MR images were acquired with 3.0-T MR imaging systems [uMR 780 (United Imaging), or Achieva (Philips), or Espree (Siemens Healthcare), or Discovery MR 750 (GE)]. T1w images were acquired at repetition time of 160–2,836.25 ms, echo time of 8–43 ms, and section thickness of 4.0–6.0 mm. T1c images were acquired at repetition time of 110–1,900 ms, echo time of 1.8–22 ms, and section thickness of 0.85–6.0 mm. T2w images were obtained with repetition time of 1,991.31–12,528.89 ms, echo time of 76.2–139.55 ms, and section thickness of 4.0–8.0 mm. FLAIR images were obtained with a repetition time of 2,000–9,600 ms, echo time of 20–141.3 ms, and section thickness of 4.0–6.0 mm.
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