Trp53fl fl mice

Gen1^−/− mice were generated at the Memorial Sloan Kettering Cancer Center Mouse Genetics Core Facility. Mus81^fl/fl mice were generated using ES cell clone purchased from EUCOMM (Skarnes et al., 2011 (link)). Mb1 (Cd79a)-Cre mice were purchased from The Jackson Laboratory (strain #:020505) (Hobeika et al., 2006 (link)). Cd23-Cre (Kwon et al., 2008 (link)) and Aicda^−/− (Muramatsu et al., 2000 (link)) mice were gifted by Meinrad Busslinger (Research Institute of Molecular Pathology, Austria) and Tasuku Honjo (University of Kyoto, Japan), respectively. Trp53^fl/fl mice were purchased from The Jackson Laboratory (strain #:008462) (Marino et al., 2000 (link)). Experiments were performed using mice between 8- and 16-week-old. When littermate controls were unavailable, age-matched controls were employed in experiments. All mice were housed and maintained in groups of five under specific pathogen-free conditions, and euthanized at the time of analyses in accordance with guidelines for animal care established by Memorial Sloan Kettering Cancer Center Research Animal Resource Center and the Institutional Animal Care and Use Committee (IACUC).