Vantage titan 3t scanner

¹⁸F-THK5351 and ¹¹C-Pittsburgh compound B (PiB) were manufactured at the Cyclotron and Radioisotope Center of Tohoku University using a semiautomated system developed in-house. The injectable solutions of ¹⁸F-THK5351 and ¹¹C-PiB were obtained with a radiochemical purity of >95% and specific activity of 357 ± 270 and 240 ± 48 GBq/μmol. PET imaging was performed using an Eminence STARGATE scanner (Shimadzu, Kyoto, Japan). After rapidly injecting 185-MBq ¹⁸F-THK5351 or 296-MBq ¹¹C-PiB, PET images were obtained for 20 min (4 scans × 300 s) from 40 to 60 min or 50–70 min postinjection and used for further analysis. In addition, a 3D volumetric acquisition of a T1-weighted gradient echo sequence produced a gapless series of thin axial sections using a spoiled gradient recall sequence (echo time/repetition time, 3.4/7.2 ms; flip angle, 9°; acquisition matrix, 240 × 256; 1 excitation; field of view, 25.6 cm; slice thickness, 0.8 mm) of a Vantage Titan™ 3T scanner (Canon Medical Systems, Otawara, Japan).

We retrospectively enrolled patients who underwent both PET/CT and MRI at the Peking Union Medical College Hospital. The PET/CT scan was performed on a Siemens BioGraph PET/CT scanner (Siemens Healthineers, Erlangen, Germany). The whole-body PET/CT scanning protocol was described in a previous study [28 (link)]. A separate head CT imaging was also performed, and a full head coverage from vertex to skull base was achieved. The voltage output of the X-Ray generator was 120 kVp and the X-Ray tube current was 300 mAs. The head CT images had the voxel spacing (resolution) of 0.6 × 0.6 × 1.5 mm³ with dimensions of 512 × 512 × 148. The MRI scan was performed on a Toshiba Vantage Titan 3 T scanner (Canon Medical Systems, Tochigi, Japan). Both T1-weighted (T1-w) and T2-weighted (T2-w) MR images were acquired. T1-w images were obtained using the sequence with the following parameters: TR 2100 ms, TE 10 ms, TI 900 ms. T2-w images used these parameters: TR 4650 ms, TE 95 ms. For both T1-w images and T2-w images, the dimensions were 640 × 640 × 24 and the voxel spacing was 0.36 × 0.36 × 6 mm³. During post-processing, both CT images and MR images were reconstructed to have the same resolution of 1 × 1 × 2 mm³, resulting in a single voxel volume of 2 mm³.