Elecys 2010 analyzer

Manufactured by Roche

Sourced in United States, United Kingdom

The Roche Elecsys 2010 Analyzer is an automated immunoassay analyzer used in clinical laboratories. It is designed for the quantitative determination of various analytes in human samples, such as serum, plasma, and urine. The Elecsys 2010 Analyzer utilizes electrochemiluminescence (ECL) technology to perform immunoassay tests, providing accurate and reliable results.

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Cobas e411 analyzer, by Roche (3 mentions) Elecsys 2010 analyzer, by Roche (1 mentions)

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Elecys 2010 (4 citations)

6 protocols using elecys 2010 analyzer

Cardiac Troponin T Measurement Across Time

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Cardiac troponin T was measured at 2 time points, 6 years apart, using the same highly sensitive (precommercial) sandwich immunoassay method (Roche Elecsys T, Roche Diagnostics, Indianapolis, IN). We measured hs-cTnT in stored serum samples collected at visit 2 using a Roche Elecys 2010 Analyzer (Roche Diagnostics, Indianapolis, Indiana) at the University of Minnesota in 2012–2013. Samples had been stored since collection at −70°C. Coefficients of variation (CVs) were 6.0% at a mean cTnT concentration of 25 ng/L and 3.7% at a concentration of 1940 ng/L. ^{8 (link)} We measured hs-cTnT in stored plasma samples from visit 4 using the same assay implemented on a Cobas e411 analyzer (Roche Diagnostics, Indianapolis, Indiana) at Baylor College of Medicine in 2010. Plasma samples had been stored since collection at −80°C. CVs were 6.9% and 2.6% at mean cTnT concentrations of 29 ng/L and 2378 ng/L. ¹⁴ Finally, a formal calibration study evaluating heterogeneity across specimen type and laboratory has been conducted and no significant differences were observed (N=200 paired samples). ¹⁵

McEvoy J.W., Lazo M., Chen Y., Shen L., Nambi V., Hoogeveen R.C., Ballantyne C.M., Blumenthal R.S., Coresh J, & Selvin E. (2015). Patterns and Determinants of Temporal Change in High-sensitivity Cardiac Troponin-T: The Atherosclerosis Risk in Communities Cohort Study. International journal of cardiology, 187, 651-657.

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Cardiac Biomarker Measurement Protocols

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hs-cTnT was measured using a high-sensitive sandwich immunoassay method (Roche Elecsys T; Roche Diagnostic). Stored serum samples obtained at visit 2 were assayed for hs-cTnT using a Roche Elecsys 2010 Analyzer (Roche Diagnostics). Stored plasma samples obtained at visit 4 and visit 5 were assayed for hs-cTnT using a Cobas e411 analyzer (Roche Diagnostics, Indianapolis, Indiana). For NT-proBNP, stored serum samples obtained at visit 2 were measured using a sandwich immunoassay method (Roche Diagnostics) implemented on a Roche Elecys 2010 Analyzer. Stored plasma samples collected at visit 4 and visit 5 were analyzed using an electrochemiluminescent immunoassay on an automated Cobas e411 analyzer (Roche Diagnostics). The as is measurable limit of hs-TnT and NT-proBNP were 3 ng/L and 5 pg/mL, respectively. We assigned half the lower limit of each marker for participants with unmeasurable levels.

Mok Y., Sang Y., Ballew S.H., Hoogeveen R.C., Ballantyne C.M., Rosamond W., Coresh J., Selvin E, & Matushita K. (2019). Premorbid levels of high-sensitivity cardiac troponin T and natriuretic peptide and prognosis after incident myocardial infarction. American heart journal, 216, 62-73.

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Longitudinal High-Sensitivity Cardiac Troponin T Measurement

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Cardiac troponin T was measured at two time points, 6 years apart, using the same highly sensitive (pre-commercial) sandwich immunoassay method (Roche Elecsys T; Roche Diagnostics, Indianapolis, Indiana). We measured hs-cTnT in stored serum samples collected at visit 2 (1990-1992) using a Roche Elecys 2010 Analyzer (Roche Diagnostics) at the University of Minnesota in 2012-2013. We measured hs-cTnT in stored plasma samples collected at visit 4 (1996-1998) using a Cobas e411 analyzer (Roche Diagnostics) at Baylor College of Medicine. We conducted a formal calibration study (N=200 paired samples) to evaluate possible differences across specimen type and laboratory. No significant differences were observed and statistical correction was not indicated ²⁵.

Selvin E., Lazo M., Chen Y., Shen L., Rubin J., McEvoy J.W., Hoogeveen R.C., Sharrett A.R., Ballantyne C.M, & Coresh J. (2014). Diabetes, Pre-Diabetes and Incidence of Subclinical Myocardial Damage. Circulation, 130(16), 1374-1382.

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Mixed-Meal Tolerance Test for C-Peptide

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The mixed-meal tolerance test (Boost™ Nutritional Drink, Nestle, Vevey, Switzerland) was conducted after a 10-h fast, preceded by a 3-day consumption of a high carbohydrate diet of ≥150 g, and a fasting blood glucose of 70–200 mg/dl the morning of the test. The mixed meal was given at a dose of 6 ml per kg body weight, with a maximum dose of 360 ml. Timed collections were obtained at −10, 0, 15, 30, 60, 90, 120, 180 and 240 min relative to the ingestion of the stimulus at time zero. All samples were frozen on the day of collection at −70° C and thawed only once at the time of assay. C-peptide was assayed from plasma at all of these times with the Roche Elecys 2010 Analyzer (Roche Diagnostics Corp., Indianapolis, IN, USA) using a chemiluminescent immunoassay method (Roche Diagnostics Corp.) in the DCCT/EDIC Central Biochemistry Laboratory at the University of Minnesota. The laboratory interassay coefficient of variation is 2.7% at low concentrations. We report all C-peptide concentrations, with the lowest at 0.004 nmol/l, in effect the lower limit of detection.

McGee P., Steffes M., Nowicki M., Bayless M., Gubitosi-Klug R., Cleary P., Lachin J, & Palmer J. (2014). Insulin secretion measured by stimulated C-peptide in long-established Type 1 diabetes in the Diabetes Control and Complications Trial (DCCT)/ Epidemiology of Diabetes Interventions and Complications (EDIC) cohort: a pilot study. Diabetic medicine : a journal of the British Diabetic Association, 31(10), 1264-1268.

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Thyroid Dysfunction Screening in Young Women

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The study was conducted in seven colleges in the area of Madurai District. This was representative of the mix of the urban plus rural population. This study subjects were women aged 18–25 years. We visited each college and all female students in the above age group were invited to participate in the study. Only those who were willing to give blood samples were included in the study after informed consent.
Thyroid-stimulating hormone (TSH) assay was done in all blood samples as a screening test for thyroid disease. TSH assay was performed using electrochemiluminescence immunoassay on the Elecys 2010 Analyzer (Roche Diagnostics) It is a sandwich assay and the method has been standardized against the 2^nd IRP WHO Reference Standard 80/558. The functional sensitivity of the TSH kit was 0.014 mIU/ml. The laboratory's reference value for TSH was 0.4–4.5 mIU/ml. All the subjects with abnormal TSH were requested to come for follow-up for further testing.
Abnormal TSH values were grouped into three categories:

Mild TSH elevation: TSH of 4.5–10 mIU/ml

Significant TSH elevation: TSH > mIU/ml

Suppressed TSH: TSH <0.4 mIU/ml.

Velayutham K., Selvan S.S, & Unnikrishnan A.G. (2015). Prevalence of thyroid dysfunction among young females in a South Indian population. Indian Journal of Endocrinology and Metabolism, 19(6), 781-784.

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Maternal Blood Biomarker Measurement

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Non-fasting maternal blood was obtained from the antecubital vein at antenatal clinic (10-12 weeks). The CV and CA blood was obtained at delivery after clamping the umbilical cord. Maternal and cord blood was collected into tubes with either potassium EDTA or lithium heparin as anticoagulant, placed on ice, and centrifuged at 1000g for 10 minutes. Separated plasma was stored at 80 C and transferred for analysis (University Hospital of Wales, Cardiff). Plasma tHcy was measured by high-performance liquid chromatography and fluorometric detection following reduction, deproteinization, and derivatization with the fluorophore SBDF (ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sullfonate). 32 This assay was standardized using National Institute of Standards and Technology Standard Reference Material. Plasma folate and Cbl were measured by competitive protein-binding assays on an Elecys 2010 analyzer (Roche Diagnostics, Burgess Hill, West Sussex, UK).

D'Souza S.W., Solanky N., Guarino J., Moat S., Sibley C.P., Taggart M, & Glazier J.D. (2017). Human Placental Arterial Distensibility, Birth Weight, and Body Size Are Positively Related to Fetal Homocysteine Concentration. Reproductive sciences (Thousand Oaks, Calif.), 24(7).

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