Lunar prodigy advance dxa scanner

Manufactured by GE Healthcare

Sourced in United States

The Lunar Prodigy Advance DXA scanner is a medical imaging device used for the assessment of bone density. It utilizes dual-energy X-ray absorptiometry (DXA) technology to measure the bone mineral content and density of various regions of the body. The scanner provides precise and accurate measurements, which are essential for the diagnosis and monitoring of conditions such as osteoporosis.

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4 protocols using lunar prodigy advance dxa scanner

Whole-Body Composition Measures via DXA

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Criterion whole body measures of body composition were obtained using a Lunar Prodigy Advance DXA scanner (General Electric Healthcare, Encore Software Version 16). Prior to each scan, the DXA was calibrated according to the manufacturer’s instructions using a standard calibration block. Whole body scans were performed with participants in a supine position on the scanning bed with hands at their side. The following whole-body derivative values were calculated using the following equations:

LBMI and FMI were converted to sex- and age-adjusted z-scores for the participants in the study.

Holmes C.J., Racette S.B., Symonds L., Arbeláez A.M., Cao C, & Granados A. (2022). Feasibility and Efficacy of Telehealth-Based Resistance Exercise Training in Adolescents with Cystic Fibrosis and Glucose Intolerance. International Journal of Environmental Research and Public Health, 19(6), 3297.

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Assessing Bone Density in ADO2 Patients

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Areal bone mineral density was measured for the lumbar spine (L1-L4), total hip, femur neck, and whole-body using a GE Lunar Prodigy Advance DXA scanner (Madison, WI, USA). DXA assessment of energy absorption within the projected bone area included tissue of both higher and lower densities, as is standard technique. ADO2 patients have areas of lower density bone within the projected image, but absorption (reflecting bone density) is measured across the total area (i.e. low and high density) and compared to the same composite in ‘normal’ individuals. As per standard technique, visual assessment of the vertebral bodies and hip confirmed appropriate area of interest demarcation, including both dense endplates and relatively decreased mineralization centrally in vertebral bodies, as well as excluding analysis of hips with prior fractures or hardware. The underlying anatomy, as evidenced by the skeletal survey, revealed no confounding factors, such as osteophytosis, that may result in falsely elevated bone mineral density [19 (link)]. Z-scores were calculated from age, sex and race normative data using the manufacturer’s software Version 13.6.

Ladd L.M., Imel E.A., Niziolek P.J., Liu Z., Warden S.J., Liang Y, & Econs M.J. (2020). Radiographic imaging, densitometry and disease severity in Autosomal dominant osteopetrosis type 2.. Skeletal radiology, 50(5), 903-913.

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Whole-Body Composition Analysis via DXA

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Criterion whole-body measures of FM and %Fat were obtained using a Lunar Prodigy Advance DXA scanner (General Electric Healthcare, Encore Software Version 16). Prior to each scan, the DXA scanner was calibrated according to the manufacturer’s instructions using a standard calibration block. Whole-body scans were performed with participants in a supine position on the scanning bed with hands at their sides. FFM was calculated using the equation outlined in the previous section.

Holmes C.J., Racette S.B., Symonds L., Arbeláez A.M., Cao C, & Granados A. (2022). Comparison of Bioelectrical Impedance Analysis with DXA in Adolescents with Cystic Fibrosis before and after a Resistance Training Intervention. International Journal of Environmental Research and Public Health, 19(7), 4037.

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Bone Composition Analysis by DXA

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After removing the head and ovary, BC was analyzed from the same carcasses at 14, 16, 18, 20, 22, and 25 woa (n = 6 birds/treatment/strain) via Dual Energy X-ray Absorptiometry (DXA). After euthanasia, carcasses were placed at 4°C to slowly decrease the core temperature before being stored at −20°C until analysis. Before DXA scanning, all carcasses were placed at 4°C for 48 h and then at room temperature until thawed. Scans were performed using a Lunar Prodigy Advance DXA scanner (GE Healthcare, Madison, WI) with the enCore software version 16. A quality assurance block was conducted daily prior to the scans to calibrate the machine. Carcasses were placed on the scanning bed in a uniform lateral position. DXA scans were run using the small animal setting in small mode according to Swennen et al. (2004) (link) to measure, BMC (g), total bone area (cm²), fat tissue weight (g), lean tissue weight (g) and total tissue weight (g). Fat % and lean % were calculated as

(\frac{f a t o r l e a n w e i g h t}{T i s s u e w e i g h t}) \times 100

and BMD (g/cm²) was calculated as

(\frac{B M C}{t o t a l b o n e a r e a}) \times 100

Bahry M.A., Hanlon C., Ziezold C.J., Schaus S, & Bédécarrats G.Y. (2023). Impact of growth trajectory on sexual maturation in layer chickens. Frontiers in Physiology, 14, 1174238.

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