Rag2 andrag2 il2rg

Wild-type,
Rag1^−/−, Thy1.1,
OT-II, Lck^cre,
Il1r^f/f,
H2-Ab1^f/f,
Csf2^−/−,
Myd88^−/− and
Nod2^−/− mice on a
C57BL/6 background were purchased from the Jackson Laboratory.
Rag2^−/− and
Rag2^−/−Il2rg^−/−on a C57BL/6 background were purchased from Taconic Farms. C57BL/6
Rorc^cre mice and
Rorc(γt)-Gfp^TG mice were
provided by G. Eberl. C57BL/6
Il2^f/f mice were provided by K.
A. Smith. C57BL/6 Ncr1^cre were
provided by E. Vivier and only heterozygous
Ncr1^cre mice were utilized
in this study. All mice were bred and maintained in specific pathogen-free
facilities at Weill Cornell Medicine and littermates were used as controls in
all experiments. C57BL/6 germ free mice were maintained at the gnotobiotic
facility at Weill Cornell Medicine. Sex- and age-matched animals between 8 and
14 weeks of age were used for experiments if not otherwise indicated. Gender was
not found to influence results of any experiments. No animals were excluded from
the analysis unless clearly indicated. All animal experiments were approved and
are in accordance with the Institutional Animal Care and Use Committee
guidelines at Weill Cornell Medicine.