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Leucovorin lv

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Leucovorin (LV) is a form of the B vitamin folate. It is used in combination with certain chemotherapy medications to help reduce side effects and improve the effectiveness of the treatment.

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Lab products found in correlation

Celltiter glo assay, by Promega (2 mentions) L ohp, by Merck Group (1 mentions)

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Leucovorin (6 citations)

3 protocols using leucovorin lv

1

Evaluating Leucovorin's Cytotoxicity Effects

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HCT116 cells were allowed to grow in folic acid free DMEM for a few months until cells reached normal doubling time of about 20 h. Ten μmol/L of leucovorin (LV; Sigma, St. Louis, Missouri) was co-treated with 5-FU and F10 for 72 h as described before along with a drug control. Cell viability was assessed using Promega’s CellTiter-Glo assay as described before. Results were plotted using GraphPad Prism.
Dominijanni A, & Gmeiner W.H. (2018). Improved potency of F10 relative to 5-fluorouracil in colorectal cancer cells with p53 mutations. Cancer drug resistance (Alhambra, Calif.), 1, 48-58.
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2

Evaluating Leucovorin's Cytotoxicity Effects

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HCT116 cells were allowed to grow in folic acid free DMEM for a few months until cells reached normal doubling time of about 20 h. Ten μmol/L of leucovorin (LV; Sigma, St. Louis, Missouri) was co-treated with 5-FU and F10 for 72 h as described before along with a drug control. Cell viability was assessed using Promega’s CellTiter-Glo assay as described before. Results were plotted using GraphPad Prism.
Dominijanni A, & Gmeiner W.H. (2018). Improved potency of F10 relative to 5-fluorouracil in colorectal cancer cells with p53 mutations. Cancer drug resistance (Alhambra, Calif.), 1, 48-58.
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3

Synergistic Effects of FOLFOX Chemotherapy

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L-OHP, 5-FU, and leucovorin (LV) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Stock solutions of these drugs were prepared in sterile distilled water with filtration. We chose concentrations of these drugs that caused 80%–90% growth reduction when used alone for HCT116 cell line: 2.5 µM of L-OHP, 25 µM of 5-FU, and 25 µM of LV. Cells were exposed to FL regimen (5-FU/LV) or folfox regimen (L-OHP/5-FU/LV) at 18 hours after transfection.
Oh B.Y., Kim K.H., Chung S.S, & Lee R.A. (2016). Silencing the livin gene enhances the cytotoxic effects of anticancer drugs on colon cancer cells. Annals of Surgical Treatment and Research, 91(6), 273-277.
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