Signa 750

Manufactured by GE Healthcare

Sourced in United States

The SIGNA 750 is a magnetic resonance imaging (MRI) system developed by GE Healthcare. It is designed to provide high-quality imaging capabilities for healthcare professionals. The SIGNA 750 utilizes advanced technology to capture detailed images of the body's internal structures, enabling medical professionals to make informed diagnoses and treatment decisions.

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Lab products found in correlation

Magnetom trio, by Siemens (4 mentions) Signa 750, by Siemens (2 mentions) Matlab, by MathWorks (1 mentions) Ecat hr pet scanner, by Siemens (1 mentions) Magnetom prisma, by Siemens (1 mentions)

Close spelling variants of this product

Signa Excite 750

11 protocols using signa 750

Gradient Defocusing for Artifact Avoidance

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The MASTER sequence was implemented on a 3T GE Signa 750 scanner using developmental builds SpinBench and RTHawk (HeartVista, Inc. Menlo Park, CA USA) [27 (link)]. A single-channel GE head coil was used for transmit and receive in the initial validation experiment, and the body coil was used for the subsequent comparison experiments. All analysis was performed using MATLAB (The Mathworks, Inc. Natick, MA USA).
As an estimate of the minimum necessary gradient defocusing area to avoid inter-slice interference, a simple GRE sequence was used to image a GE grid phantom with different amounts of k_z offset. At a k_z offset of 6.66 cycles/cm, measurements at a k_x offset of 5 cycles/cm were similar in magnitude to the noise floor. A conservative minimum diffusion offset of 7.5 cycles/cm in k_z and 15 cycles/cm in k_x or k_y was used in all of the work presented here.

Marx M., Plata J, & Pauly K.B. (2014). Toward Volumetric MR Thermometry with the MASTER Sequence. IEEE transactions on medical imaging, 34(1), 148-155.

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PiB-PET and MRI Imaging Protocol

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For PET scans, [¹¹C]PiB scans were acquired on Siemens ECAT HR + PET scanners at both sites using a nominal dose of 15 mCi of radiotracer. Preprocessing of dynamic [¹¹C]PiB data was performed in AIR, version 3.0 [26] . Dynamic PET data were corrected for inter frame motion and averaged over 50–70 min after injection. Parametric SUVR images were generated using a cerebellar gray matter ROI. For MRI scans, T1-weighted MRIs were acquired on a 3.0 T GE SIGNA 750 at the University of Wisconsin-Madison site and on a 3.0 T Siemens Magnetom Trio at the University of Pittsburgh Medical Center site. The SIGNA 750 acquisition used high-resolution volumetric spoiled gradient sequence (TI/TE/TR = 450/3.2/8.2 ms, flip angle = 12°, slice thickness = 1 mm no gap, matrix size = 256 × 256 × 156), whereas the Magnetom Trio acquisition used a magnetization prepared rapid acquisition gradient echo sequence (TI/TE/TR = 900/2.98/2300 ms, flip angle = 9°, slice thickness = 1.2 mm, matrix size = 160 × 240 × 256).

Tudorascu D.L., Minhas D.S., Lao P.J., Betthauser T.J., Yu Z., Laymon C.M., Lopresti B.J., Mathis C.A., Klunk W.E., Handen B.L., Christian B.T, & Cohen A.D. (2018). The use of Centiloids for applying [11C]PiB classification cutoffs across region-of-interest delineation methods. Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, 10, 332-339.

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Multimodal Imaging and Amyloid Burden

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A subset of participants (N = 285) underwent T1‐weighted magnetic resonance imaging (MRI; 3T GE Signa 750) as well as Aβ (¹¹C‐Pittsburgh compound B [PiB]) positron emission tomography (PET) imaging. Detailed methods for radioligand synthesis and PET and MRI acquisition, processing and quantification, and analysis were implemented as reported previously.²⁹, ³⁰ Aβ burden was assessed as a global cortical average PiB distribution volume ratio (DVR),²⁹ and a previously established threshold of DVR >1.19 was used to determine Aβ positivity.³¹ Age of Aβ onset and Aβ duration (age at visit – estimated age Aβ+), defined as the approximate number of years that an individual has had suprathreshold Aβ positivity, were estimated using a combination of group‐based trajectory modeling and Bayes’ theorem.⁶

Cody K.A., Koscik R.L., Erickson C.M., Berman S.E., Jonaitis E.M., Williams V.J., Mueller K.D., Christian B.T., Chin N.A., Clark L.R., Betthauser T.J, & Johnson S.C. (2022). Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention. Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, 14(1), e12351.

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Neuroimaging of Face-Emotion and Visual Search

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Neuroimaging data were collected on two 3T General Electric Signa 750 scanners each using a 32‐channel head coil with identical acquisition sequences. After a sagittal localizer scan, an automated shim calibrated the magnetic field to reduce signal dropout due to susceptibility artifact. BOLD signal was measured by T2*‐weighted echo‐planar imaging at a voxel resolution of 2.5 × 2.5 × 3.0 mm (repetition time = 2,300 ms, field of view = 24.0 mm, frequency × phase: 96 × 96; face‐emotion labeling: 179 volumes, flip angle = 70°, echo time = 30 ms, visual search: 151 volumes, flip angle = 75°, echo time = 25 ms). To reach longitudinal magnetization equilibrium, the four initial images from each run were discarded. A structural MPRAGE scan (echo time = min full; inversion time = 425; field of view = 25.6; frequency × phase = 256 × 256; flip angle = 7°; 1 mm isotropic voxels) was acquired for co‐registration with the functional data.

Haller S.P., Chen G., Kitt E.R., Smith A.R., Stoddard J., Abend R., Cardenas S.I., Revzina O., Coppersmith D., Leibenluft E., Brotman M.A., Pine D.S, & Pagliaccio D. (2022). Reliability of task‐evoked neural activation during face‐emotion paradigms: Effects of scanner and psychological processes. Human Brain Mapping, 43(7), 2109-2120.

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Multimodal MRI Acquisition and Preprocessing

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T1 weighted 3.0 T MRI scans were acquired on a GE SIGNA 750 (UW-Madison) or a Siemens Magnetom Trio (UPMC). The SIGNA 750 acquired data using a high resolution volumetric spoiled gradient sequence (TI/TE/TR = 450/3.2/8.2 ms, flip angle = 12°, slice thickness = 1 mm no gap, matrix size = 256x256x156). The Magnetom Trio acquired data using a magnetization prepared rapid acquisition gradient echo sequence (MPRAGE; TI/TE/TR = 900/2.98/2300 ms, flip angle = 9°, slice thickness = 1.2 mm, matrix size = 160x240x256). In the 68 available baseline T1 MRI images, 8 (12%) were flagged at UPMC during preprocessing as containing “severe motion” or “significant motion”, leaving 60 T1 MRIs suitable for tissue type segmentation.
T2 weighted MRIs were also acquired on a 3.0 T GE SIGNA 750 (TE/TR = 85/9000 ms, slice thickness = 2 mm no gap, matrix size = 256x256x96) at UW-Madison. T2 weighted MRIs acquired at UPMC were not available for this analysis. Of the 40 available baseline T2 MRI images, 3 (7.5%) were flagged at UPMC during preprocessing as containing “severe motion” or “significant motion”, leaving 37 T2 MRIs suitable for tissue type segmentation.

Lao P.J., Handen B.L., Betthauser T.J., Cody K.A., Cohen A.D., Tudorascu D.L., Stone C.K., Price J.C., Johnson S.C., Klunk W.E, & Christian B.T. (2018). Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation. Brain Imaging and Behavior, 13(2), 345-353.

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MRI Protocol for PET-MRI Registration

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Magnetic resonance imaging (MRI) scans were conducted on 3.0T MRI scanners; specifically, a GE SIGNA 750 with an 8-channel head coil (University of Wisconsin-Madison site) and Siemens Magnetom Prisma scanner with a 64-channel head coil (University of Pittsburgh site). MRI data were used for PET-MRI registration, region definition, and magnetic resonance-guided correction of PET Aβ and tau data. At Wisconsin, T1-weighted MRI brain images were acquired in the sagital plane with a high resolution volumetric-spoiled gradient sequence (inversion time/echo time/repetition time = 400/3.0/7.4 ms, flip angle = 11°, slice thickness = 1.2 mm no gap, and matrix size = 256 × 256 × 196). At Pittsburgh, T1-weighted MRI brain images were acquired in the sagittal plane with a Magnetization Prepared Rapid Gradient Echo sequence (inversion time/echo time/repetition time = 900/2.95/2300 ms, flip angle = 9.0°, slice thickness = 1.2 mm, and matrix size = 240 x 256 x 176).

Fleming V., Gambetti B., Patrick A., Zammit M., Alexander A., Christian B.T., Handen B., Cohen A., Klunk W., Laymon C., Okonkwo O., Ances B.M., Plante D.T, & Hartley S.L. (2021). Physical Activity and Cognitive and Imaging Biomarkers of Alzheimer’s Disease in Down Syndrome. Neurobiology of aging, 107, 118-127.

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Multimodal MRI Acquisition and Quality Control

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T1 weighted 3.0 T MRI scans were acquired on a GE SIGNA 750 (UW-Madison) or a Siemens Magnetom Trio (UPMC). The SIGNA 750 acquired data using a high resolution volumetric spoiled gradient sequence (TI/TE/TR = 450/3.2/8.2 ms, flip angle = 12°, slice thickness = 1 mm no gap, matrix size = 256×256×156). The Magnetom Trio acquired data using a magnetization prepared rapid acquisition gradient echo sequence (MPRAGE; TI/TE/TR = 900/2.98/2300 ms, flip angle = 9°, slice thickness = 1.2 mm, matrix size = 160×240×256). In the 68 available baseline T1 MRI images, 8 (12%) were flagged at UPMC during preprocessing as containing “severe motion” or “significant motion”, leaving 60 T1 MRIs suitable for tissue type segmentation.
T2 weighted MRIs were also acquired on a 3.0 T GE SIGNA 750 (TE/TR= 85/9000 ms, slice thickness = 2 mm no gap, matrix size = 256×256×96) at UW-Madison. T2 weighted MRIs acquired at UPMC were not available for this analysis. Of the 40 available baseline T2 MRI images, 3 (7.5%) were flagged at UPMC during preprocessing as containing “severe motion” or “significant motion”, leaving 37 T2 MRIs suitable for tissue type segmentation.

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3T MRI Acquisition Protocol

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T1-weighted MRIs were acquired on a 3T GE SIGNA 750 at the University of Wisconsin-Madison site and on a 3T Siemens Magnetom Trio at the University of Pittsburgh site. The SIGNA 750 acquisition used high resolution volumetric spoiled gradient sequence (TI/TE/TR=450/3.2/8.2ms, flip angle=12°, slice thickness=1mm no gap, matrix size=256×256×156), while the Magnetom Trio acquisition used a magnetization prepared rapid acquisition gradient echo (MPRAGE) sequence (TI/TE/TR=900/2.98/2300ms, flip angle=9°, slice thickness=1.2 mm, matrix size=160×240×256).

Tudorascu D.L., Anderson S.J., Minhas D.S., Yu Z., Comer D., Lao P., Hartley S., Laymon C.M., Snitz B.E., Lopresti B.J., Johnson S., Price J.C., Mathis C.A., Aizenstein H.J., Klunk W.E., Handen B.L., Christian B.T, & Cohen A.D. (2018). Comparison of longitudinal Aβ in non-demented elderly and Down syndrome. Neurobiology of aging, 73, 171-176.

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High-resolution 3T MRI brain imaging

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T1-weighted 3.0 T MRI scans were acquired on a SIGNA 750 (General Electric) for image coregistration and region of interest (ROI) definition. The SIGNA 750 acquisition used a high resolution volumetric spoiled gradient sequence (TI/TE/TR:450/3.2/8.2 ms, flip angle:12°, slice thickness:1 mm no gap, FOV:256, matrix size:256 × 256 × 156).

Lao P.J., Betthauser T.J., Tudorascu D.L., Barnhart T.E., Hillmer A.T., Stone C.K., Mukherjee J, & Christian B.T. (2017). [18F]Nifene test–retest reproducibility in first-in-human imaging of α4β2* nicotinic acetylcholine receptors. Synapse (New York, N.Y.), 71(8), 10.1002/syn.21981.

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Cardiac MRI Assessment Protocol

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CMR assessments were performed either on a 1.5-T scanner at the UMCG (Siemens, Erlangen, Germany, SUMC and LPCG; Signa TwinSpeed, Signa 450-w) or a 3 T MR scanner at SUMC (Signa 750, GE Healthcare, Wisconsin, the United States). A retrospectively gated steady-state freeprecession (SSFP) sequence was used to obtain ECG-gated cine loop images with breath holding. The four-chamber view was used for long-axis slices and short-axis slices were subsequently acquired covering both ventricles from base to apex. To help define positions of the tricuspid and mitral valves, additional SSFP cine images were taken in the long axis planes. All non-sedated patients were instructed to hold their breath during the examinations, and the images were acquired during end-expiratory breath holds. Two-dimensional velocity encoded CMR flow measurements, perpendicular and ± 1.5 cm cranial to the pulmonary valve, were performed using 2-D gradient echo Fast Low Angle SHot (FLASH), acquired during normal respiration with retrospective cardiac gating.

Beurskens N.E.G., Hagdorn Q.A.J., Gorter T.M., Berger R.M.F., Vermeulen K.M., van Melle J.P., Ebels T.E., Lui G.K., Ceresnak S.R., Chan F.P, & Willems T.P. (2019). Risk of cardiac tachyarrhythmia in patients with repaired tetralogy of Fallot: a multicenter cardiac MRI based study. The international journal of cardiovascular imaging, 35(1).

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