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Azd5991

Manufactured by Chemietek
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Sourced in United States

AZD5991 is a laboratory instrument designed for the analysis and measurement of various chemical and biological samples. It utilizes advanced technological principles to provide accurate and reliable data. The core function of AZD5991 is to facilitate scientific research and experimentation, but its specific applications may vary depending on the user's requirements.

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Lab products found in correlation

Abt 199, by Selleck Chemicals (2 mentions) A 1155463, by Chemietek (2 mentions) Dimethyl sulfoxide (dmso), by Merck Group (2 mentions) Trametinib, by Selleck Chemicals (1 mentions) Amg 176, by Chemietek (1 mentions) Degrasyn wp1130, by Selleck Chemicals (1 mentions) Maritoclax, by Selleck Chemicals (1 mentions) Oxaliplatin, by Merck Group (1 mentions) Wehi 539, by Selleck Chemicals (1 mentions) 5 aza 2 deoxycytidine decitabine, by Merck Group (1 mentions) Abt 263, by Selleck Chemicals (1 mentions) Q vd oph, by Selleck Chemicals (1 mentions) Rapamycin, by Thermo Fisher Scientific (1 mentions) Chloroquine, by Merck Group (1 mentions) Cb 839, by Selleck Chemicals (1 mentions) Ibrutinib, by Selleck Chemicals (1 mentions) Bafilomycin a1, by Merck Group (1 mentions) Molecular grade water, by Corning (1 mentions)

4 protocols using azd5991

1

Evaluation of Novel Anticancer Agents

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AMG-176 and AZD5991 were purchased from Chemietek; MG-132, Degrasyn (WP1130), Maritoclax, and trametinib were purchased from Selleckchem, Houston, TX. Agents were dissolved in DMSO (Sigma-Aldrich, Burlington, MA).
Tantawy S.I., Sarkar A., Hubner S., Tan Z., Wierda W.G., Eldeib A., Zhang S., Kornblau S, & Gandhi V. (2023). Mechanisms of MCL-1 protein stability induced by MCL-1 antagonists in B-cell malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research, 29(2), 446-457.
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2

Compound Preparation Protocol

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ABT-199 and WEHI-539 were purchased from Selleck Chemicals (Breda, The Netherlands), A-1155463 and AZD5991 from Chemietek (Indianapolis, USA). 5-Aza-2′-deoxycytidine (Decitabine) and Oxaliplatin were purchased from Sigma Aldrich. All compounds were dissolved in DMSO to a stock of 20 mM, except Oxaliplatin, which was dissolved in water to a stock of 12.5 mM.
Ramesh P., Lannagan T.R., Jackstadt R., Atencia Taboada L., Lansu N., Wirapati P., van Hooff S.R., Dekker D., Pritchard J., Kirov A.B., van Neerven S.M., Tejpar S., Kops G.J., Sansom O.J, & Medema J.P. (2021). BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer. Cell Death and Differentiation, 28(12), 3282-3296.
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3

Chemical Compound Preparation Protocol

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ABT-199, ABT-263, and Q-VD-OPh were purchased from Selleckchem, Houston, TX, US. A-1155463 and AZD5991 were purchased from Chemietek, Indianapolis, IN, US. All compounds were dissolved in dimethyl sulfoxide (DMSO) at a 10 mM stock concentration.
Zhang L., Ramesh P., Steinmetz M, & Medema J.P. (2021). BH3 Mimetic Sensitivity of Colorectal Cancer Cell Lines in Correlation with Molecular Features Identifies Predictors of Response. International Journal of Molecular Sciences, 22(8), 3811.
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4

Combinatorial Drug Screening for Cancer

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CB-839 (0.1-100 μM; Selleckchem), L-buthionine-(S,R)-sulfoximine (BSO; 1-500 μM; Selleckchem), ibrutinib (1-20 μM; Selleckchem), venetoclax (0.01-10 μM; XcessBio), and AZD-5991 (0.25-10 μM; ChemieTek) were used in various concentrations and combinations for the treatment. Rapamycin (Thermo Fisher), bafilomycin A1 (Sigma-Aldrich), and chloroquine (Sigma-Aldrich) were used for the autophagy assays. For all drugs, except BSO, stock solutions were made in dimethyl sulfoxide (DMSO; Sigma-Aldrich), and BSO was reconstituted in molecular-grade water (Corning). DMSO only in matching concentrations (0.1-1%) was used as the vehicle control.
Timofeeva N., Ayres M.L., Baran N., Santiago-O’Farrill J.M., Bildik G., Lu Z., Konopleva M, & Gandhi V. (2023). Preclinical investigations of the efficacy of the glutaminase inhibitor CB-839 alone and in combinations in chronic lymphocytic leukemia. Frontiers in Oncology, 13, 1161254.
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