Compound b

Manufactured by Daiichi Sankyo

Compound B is a laboratory reagent used for various applications in scientific research and drug development. It serves as a key component in analytical and experimental procedures, providing a specific function without interpretation of its intended use.

Automatically generated - may contain errors

Lab products found in correlation

Geneticin g418, by Thermo Fisher Scientific (2 mentions) Doxycycline, by Merck Group (2 mentions) Puromycin, by InvivoGen (2 mentions) Ve 822, by Selleck Chemicals (1 mentions) Ly2603618, by Apexbio (1 mentions) Imatinib, by Selleck Chemicals (1 mentions) Osimertinib, by Selleck Chemicals (1 mentions) Gefitinib, by Selleck Chemicals (1 mentions) Amg510, by MedChemExpress (1 mentions) Mrtx849, by Selleck Chemicals (1 mentions)

2 protocols using compound b

Inhibitors for DNA Damage Response Pathways

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Compound B (RUVBL1 inhibitor) and Compound C (Compound B control) were synthesized by Daiichi-Sankyo. VE-822 (ATR inhibitor) was purchased from Selleckchem (catalog # S7102). LY2603618 (CHEK1 inhibitor) was purchased ApexBio (catalog # A8638). Puromycin was purchased from InvivoGen (catalog #ant-pr-1). Geneticin (G418) was purchased from ThermoFisher Scientific (catalog # 11811031). Doxycycline was purchased from MilliporeSigma (catalog # D9891).

Yenerall P., Das A.K., Wang S., Kollipara R.K., Li L.S., Villalobos P., Flaming J., Lin Y.F., Huffman K., Timmons B.C., Gilbreath C., Sonavane R., Kinch L.N., Rodriguez-Canales J., Moran C., Behrens C., Hirasawa M., Takata T., Murakami R., Iwanaga K., Chen B.P., Grishin N.V., Raj G.V., Wistuba I.I., Minna J.D, & Kittler R. (2019). RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer. Cell chemical biology, 27(1), 105-121.e14.

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Drug Resistance Screening Protocol

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Puromycin was purchased from InvivoGen (catalog # ant-pr-1) and used at 1.5 μg/mL. Geneticin (G418) was purchased from ThermoFisher Scientific (catalog # 11811031) and used at 800 μg/mL. Doxycycline was purchased from MilliporeSigma (catalog # D9891) and used at 1 μg/mL unless otherwise stated. Compound B was synthesized by Daiichi-Sankyo and used at 500 nM to identify drug-resistant cells. Gefitinib was purchased from Selleck Chemicals (catalog # S1025) and used at 1 μM to identify drug-resistant cells. Osimertinib was purchased from Selleck Chemicals (catalog # S7297) and used at 100 nM to identify drug-resistant cells. Imatinib was purchased from Selleck Chemicals (catalog # S2475) and used at 1 μM to identify drug-resistant cells. AMG 510 was purchased from MedChemExpress (catalog # HY-114277) and used at 1 μM to identify drug-resistant cells. MRTX849 was purchased from SelleckChemicals (catalog # S8884).

Yenerall P., Kollipara R.K., Avila K., Peyton M., Eide C.A., Bottomly D., McWeeney S.K., Liu Y., Westover K.D., Druker B.J., Minna J.D, & Kittler R. (2021). Lentiviral-Driven Discovery of Cancer Drug Resistance Mutations. Cancer Research, 81(18), 4685-4695.

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