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Tdt workstation

Manufactured by Tucker-Davis Technologies
Sourced in United States

The TDT Workstations are high-performance computer systems designed for research and development applications. They provide a platform for data acquisition, signal processing, and real-time analysis. The Workstations offer configurable hardware and software solutions to meet the specific needs of each customer.

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4 protocols using tdt workstation

1

Auditory Brainstem Response Measurements

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Five animals for each mouse strain were used for ABR recordings. The mouse was anesthetized with a mixture of ketamine/xylazine (ketamine 100 mg/kg; xylazine 15 mg/kg; ip), and supplemented as needed. ABRs were recorded in response to tone bursts of 2, 4, 8, 16, 22, and 32 kHz using standard procedures previously described [25 (link),26 (link)]. Tone pipe with 1 ms rise cosine on/off ramps were generated digitally using a clock rate of 125 kHz and 16-bit D/A converters. Stimulus levels were calibrated using a 1/8 inch B & K microphone (Model 4138) and were presented as sound pressure levels measured in decibels (dB SPL: referenced to 20 mPa). ABR signals were collected with subcutaneous platinum needle electrodes placed at the vertex, mastoid prominence, and shoulder. Response signals were amplified (100,000x), filtered, and acquired by TDT Workstations (Tucker-Davis Technologies). Each averaged response was based on 200 stimulus repetitions. During the procedure, the body temperature was maintained at 37°C with a heating pad. All records were obtained in a sound-attenuating chamber.
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2

Auditory Brainstem Response Thresholds in Guinea Pigs

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ABR thresholds were recorded in all guinea pigs 48 h after surgery. Animals were anesthetized with 10% chloral hydrate (0.5 mL/100 mg). The body temperature of guinea pigs was maintained at 38°C by an electric heating pad. The ABR signal was acquired through subcutaneous platinum needle electrodes at the vertex (active), the test ear (reference), and the contralateral ear pinna (ground). Response signals were amplified (100,000×), filtered, and procured via TDT Workstations (Tucker-Davis Technologies, USA). Fifteen millisecond tone bursts with a 1 ms rise/fall time were shown at a proportion of 10/s respectively at 4, 8, 16, and 32 kHz. Through reduction of the sound intensity at 5 dB intervals around the threshold, the average response to 1,000 stimuli was gained and defined as the critical value of stimulation decibel level with an evidently positive wave in the evoked response trace.
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3

Closed-Loop Deep Brain Stimulation Protocol

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Three experimental conditions were tested: Off-DBS, Traditional DBS (tDBS), and Closed-Loop (CL-DBS). tDBS consisted of a continuous biphasic pulse train (133Hz, 700μA, 80μs/phase, no interphase gap, monopolar C2 cathodic first). The pulse train for CL-DBS was similar but was triggered on only when a real-time measure of beta amplitude in the bipolar LFP activity from contacts 1–3 exceeded a pre-determined threshold level. LFP C1-3 was bandpass filtered (9–20Hz, chosen based on beta peak observed in LFP power spectral density, Fig. 1A), rectified and low-pass filtered (400ms moving average) to produce the beta amplitude signal (Fig. 1B). This signal is referred to as ‘beta’ for simplicity and because the bandpass filter peaked in the beta range, though the filter range does include much of the alpha (8–13Hz) band. CL-DBS included a 250ms ramp up/down when triggered on/off, respectively. This methodology is similar to Little et al. [15 (link)]. Recording, online processing and stimulation were programmed using a TDT workstation (Tucker Davis Technologies) operating at ~25kHz sampling rate. There was a 5 sample point delay (0.205 ms) delay between the detection of a beta threshold crossing and the change in stimulation output. The beta LFP and stimulus signals were saved for analysis (Fig. 1G)
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4

Auditory Brainstem Response Evaluation in Mice

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ABR recording experiment were performed as detailed elsewhere (38 (link)). ABR thresholds were recorded to assess the hearing of mice. Mutant and WT mice were anesthetized by i.p. injection of chloral hydrate (500 mg/kg) and the mouse temperature was maintained at 37°C–38°C. The evoked brainstem response to click (300–3000 Hz) and pure tones (8, 12, 24, 32 kHz) were amplified (50,000×) and averaged by 1024 times. The SPL from 90 to 10 dB in a 5 dB step and the lowest dB SPL level at which the ABR pattern could be recognized was defined as the ABR threshold. The Tucker-Davis Technologies (TDT) workstation provided the auditory stimulation, signal reception, and amplification; the coupled BioSigRZ software was used to analyze data.
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