Z vad fmk

Manufactured by CSNpharm

Sourced in United States

Z-VAD-FMK is a broad-spectrum caspase inhibitor. It functions by irreversibly binding and inhibiting caspase enzymes, which are crucial mediators of apoptosis (programmed cell death).

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Lab products found in correlation

Ferrostatin 1, by CSNpharm (2 mentions) Bafilomycin a1, by CSNpharm (1 mentions) Fetal bovine serum (fbs), by Thermo Fisher Scientific (1 mentions) Caki 1, by American Type Culture Collection (1 mentions) Cisplatin, by Selleck Chemicals (1 mentions) Rapamycin, by Selleck Chemicals (1 mentions) Proliferating cell nuclear antigen (pcna), by Proteintech (1 mentions) Cathepsin d, by Proteintech (1 mentions) Lamp2, by Proteintech (1 mentions) N acetyl l cysteine nac, by Beyotime (1 mentions) Dorsomorphin, by Selleck Chemicals (1 mentions) Gapdh, by Proteintech (1 mentions) P70s6k, by Proteintech (1 mentions) Capivasertib, by MedChemExpress (1 mentions) Rsl3 hy 100218a, by MedChemExpress (1 mentions) Docetaxel, by CSNpharm (1 mentions) Ver 155008, by MedChemExpress (1 mentions)

3 protocols using z vad fmk

RCC Cell Lines and Pharmacological Inhibitors

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RCC cell lines 786-O, Caki-1, A498, 769-P and ACHN and the normal cell line HK-2 were obtained from the American Type Culture Collection (Manassas, VA, USA). All cell lines were cultured in the recommended medium supplemented with 10% heat-inactivated fetal bovine serum (FBS, Gibco, Australia) at 37 °C with 5% CO₂. Chemical reagents, including ferrostatin-1 (CSN12654), z-VAD-FMK (CSN19230), necrostatin 1 (CSN11637), bafilomycin A1 (CSN10374), VX-765 (CSN15837), UNC0638 (CSN16350) and chaetocin (CSN19229) were provided by CSNpharm (Chicago, IL, USA).

Wang J., Yin X., He W., Xue W., Zhang J, & Huang Y. (2020). SUV39H1 deficiency suppresses clear cell renal cell carcinoma growth by inducing ferroptosis. Acta Pharmaceutica Sinica. B, 11(2), 406-419.

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Optimizing Autophagy Modulation for Cancer Therapy

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The reagents used in this study were purchased from Chinese suppliers: Z-VAD-fmk (CSNpharm, CSN15936, Chicago, USA), CQ (Sigma-Aldrich, C6628, St. Louis, MO, USA), NAC N-acetyl-L-cysteine (Beyotime, S0077, Shanghai, China), AO (Sigma-Aldrich, A6014), 3-MA (Selleck, S2767, Houston, Texas, USA), rapamycin (Selleck, S1039), Cisplatin (Selleck, S1166), and Dorsomorphin (Selleck, S7846). The following antibodies were also purchased from Chinese suppliers: GAPDH (Proteintech, 10,494–1-AP, Wuhan, China), cathepsin D (Proteintech, 21,327–1-AP), PCNA (Proteintech, 10,205–2-AP), Ki-67 (Proteintech, 27,309–1-AP), LAMP2 (Proteintech, 66,301–1-lg), p70s6K (Proteintech, 14,485–1-AP), tubulin (Proteintech,1124–1-AP), P21(Proteintech, 10,355–1- AP), cleaved-caspase9 (Asp175) (CST, 52873, Beverly, MA, USA), cleaved caspase 8 (Asp391) (CST,9496), Bax (CST 2774), Bid (CST,2003), Raptor (CST,2282), p-raptor(Ser792) (CST,2083), Rab7 (CST,9367), AMPK (CST, 5832), p-AMPK (CST, 2535), mTOR (CST, 2983), p-mTOR (CST,5536), p-p70s6K (CST,9234), LC3B (CST, 3868), LAMP1 (CST 15665), Atg7 (CST,8558), p62 (CST, 88588).

Yang Y., Wang Q., Song D., Zen R., Zhang L., Wang Y., Yang H., Zhang D., Jia J., Zhang J, & Wang J. (2020). Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway. Journal of Experimental & Clinical Cancer Research : CR, 39, 197.

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Ferroptosis and Apoptosis Modulation Protocols

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The ferroptosis inducer RSL3 (HY-100218 A), HSP70 inhibitor apoptozole (HY-15098), VER-155008 (HY-10941), and AKT inhibitor capivasertib (HY-15431) were procured from MedChemExpress. Additionally, Doxorubicin HCl (CSN16255), docetaxel (CSN12495), the apoptosis inhibitor Z-VAD-FMK (CSN19230), and the ferroptosis inhibitor ferrostatin-1 (CSN12654) were sourced from CSNpharm.

Shen M., Cao S., Long X., Xiao L., Yang L., Zhang P., Li L., Chen F., Lei T., Gao H., Ye F, & Bu H. (2024). DNAJC12 causes breast cancer chemotherapy resistance by repressing doxorubicin-induced ferroptosis and apoptosis via activation of AKT. Redox Biology, 70, 103035.

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