Teklad standard diet

CD1 male mice (8-weeks-old, 18–24 g) were acquired from Envigo (Milan, Italy), placed in a controlled environment and provided with standard rodent chow (Teklad standard diet acquire from Envigo) and water available ad libitum. They were housed with five mice/cage and maintained in a 12:12 h light–dark cycle at 21 ± 1 °C and 50 ± 5% humidity. The University of Messina Review Board for animal care (OPBA) approved the study (protocol number n° 211/2021-PR dated 3/16/2021). In addition, the experiments on mice complied with U.S. regulations (Animal Welfare Insurance No. A5594-01, Department of Health and Human Services, Washington, DC, USA), Europe (OJ of ECL 358/1 12/18/1986), and Italy (DM 116192).

CD1 male mice (8-week-old, 18–24 g) were acquired from Envigo (Milan, Italy) and located in a controlled environment and provided with standard rodent chow (Teklad standard diet acquire from Envigo) and water available ad libitum. They were housed 5 mice/cage and maintained in a 12:12 h light–dark cycle at 21°C ± 1°C and 50% ± 5% humidity. The University of Messina Review Board for animal care (OPBA) approved the study (P.R. 89126.8).