Tetraethoxysilane

The following reagents were used as received: Pluronic P123 (P123, Sigma-Aldrich, Saint Louis, MO, USA), tetraethoxysilane (TEOS, 99%, ABCR GmbH, Karlsruhe, Germany), HCl (36%, POCH, Polish Chemical Reagents, Gliwice, Poland), ethanol (EtOH, 99.8%, POCH, Polish Chemical Reagents, Gliwice, Poland), NaOH (POCH, Polish Chemical Reagents, Gliwice, Poland), H₂SO₄ (96%, Merck KGaA, Darmstadt, Germany), sucrose (food sugar, Pfeifer & Langen GmbH & Co. KG, Cologne, Germany), H₂O₂ (30%, Sigma-Aldrich, Saint Louis, MO, USA), dicyandiamide (99%, Sigma-Aldrich, Saint Louis, MO, USA), thiourea (>99%, Sigma-Aldrich, Saint Louis, MO, USA), diclofenac sodium salt (DICL, >98%, Sigma-Aldrich, Saint Louis, MO, USA). The above-mentioned chemicals were used as received, without further purification. Deionized water (DW, resistivity <17.5 mV cm) was obtained from a Millipore system (Merck Millipore, Burlington, MA, USA).

Polylactide (PLA) type Ingeo 2003D was purchased from NatureWorks (Minneapolis, MN, USA). The chemicals were purchased from the following sources: Tetraethoxysilane (TEOS), chlorodimethylsilane, tetramethylammonium hydroxide (TMAH) 25 wt% methanol solution from ABCR, vinyltrimethoxysilane, octadec-1-ene from Linegal Chemicals (Warsaw, Poland) chloroform-d, 2 wt% Karstedt’s catalyst xylene solution from Aldrich (Poznan, Poland), P2O5, toluene, from Avantor Performance Materials Poland S.A. (Gliwice, Poland). Toluene was degassed and dried by distilling it from P2O5 under an argon atmosphere.