2 deoxy glucose 2 dog

Manufactured by Merck Group

Sourced in United States, Spain

2-deoxy-glucose (2-DOG) is a glucose analog commonly used as a laboratory tool. It functions as a competitive inhibitor of glucose transport and phosphorylation, leading to the disruption of cellular glucose metabolism. 2-DOG is utilized in research applications to study various cellular processes related to glucose utilization and energy production.

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Lab products found in correlation

Oligomycin, by Merck Group (1 mentions) Methotrexate, by Merck Group (1 mentions) Fetal bovine serum (fbs), by Thermo Fisher Scientific (1 mentions) Liquid scintillation counting cocktail, by PerkinElmer (1 mentions) Wortmannin, by Merck Group (1 mentions) Recombinant human hgf, by Merck Group (1 mentions) Rpmi 1640 medium without glucose, by Thermo Fisher Scientific (1 mentions) Cytochalasin b, by Merck Group (1 mentions)

2 protocols using 2 deoxy glucose 2 dog

Evaluating Mitochondrial Membrane Potential

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Oligomycin (5 mM) (Sigma 04876, St. Louis, MO, USA) and 2-deoxy-glucose (2-DOG, 1 mM) (Sigma D6134, St. Louis, MO, USA) were used in experiments evaluating the mitochondrial membrane potential. Final concentration of DMSO in medium was <0.04.

Montemurro C., Nomoto H., Pei L., Parekh V.S., Vongbunyong K.E., Vadrevu S., Gurlo T., Butler A.E., Subramaniam R., Ritou E., Shirihai O.S., Satin L.S., Butler P.C, & Tudzarova S. (2019). IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function. Nature Communications, 10, 2679.

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Radioactive Tracer Uptake in Cell Culture

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Cell culture reagents (RPMI-1640 medium without glucose) and fetal bovine serum were from Invitrogen/Gibco, California, USA. The [9,10-3 [1,2-14 C]-acetic acid, L-[N-methyl- 14 C]-carnitine-HCl and liquid scintillation counting cocktail were from PerkinElmer, Massachusetts, USA. Methotrexate, Wortmannin, 2-deoxy-glucose (2-DOG) and cytochalasin B were purchased from Sigma-Aldrich (Madrid, Spain). Recombinant human HGF was purchased from Millipore Iberica (Madrid, Spain).

Visiedo F., Bugatto F., Carrasco-Fernández C., Sáez-Benito A., Mateos R.M., Cózar-Castellano I., Bartha J.L, & Perdomo G. (2015). Hepatocyte growth factor is elevated in amniotic fluid from obese women and regulates placental glucose and fatty acid metabolism. Placenta, 36(4).

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