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Miglyol 812

Manufactured by Merck Group
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Sourced in United States

Miglyol® 812 is a medium-chain triglyceride oil derived from vegetable sources. It is a clear, colorless, and odorless liquid with a low viscosity. Miglyol® 812 is commonly used as an excipient in pharmaceutical and cosmetic formulations.

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Lab products found in correlation

Tween 80, by Merck Group (2 mentions) Citral, by Merck Group (1 mentions) Nutrient dextrose agar, by Merck Group (1 mentions) Mueller hinton broth (mhb), by Merck Group (1 mentions) Mueller hinton agar (mha), by Merck Group (1 mentions) Poloxamer 407, by Merck Group (1 mentions) Precirol ato 5, by Gattefosse (1 mentions) Xanthan, by Merck Group (1 mentions) 3 4 5 dimethylthiazol 2 yl 2 5 diphenyltetrazolium bromide mtt, by Merck Group (1 mentions) Pluronic f 68 p68, by Merck Group (1 mentions) Dmem medium, by Merck Group (1 mentions) Fetal bovine serum (fbs), by Merck Group (1 mentions) Chitosan, by Merck Group (1 mentions) Rhodamine 123, by Merck Group (1 mentions) Amicon ultra 10 kda, by Merck Group (1 mentions) Gelucire 44 14, by Gattefosse (1 mentions) Low molecular weight chitosan, by Merck Group (1 mentions) Epikuron 145 5, by Cargill (1 mentions) Curcumin, by Merck Group (1 mentions) Ethanol, by Merck Group (1 mentions)

Spelling variants of this product

Miglyol (3 citations) Miglyol 812 N (2 citations)

6 protocols using miglyol 812

1

Formulation and Evaluation of Antimicrobial Topical Gel

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Citral, Tween® 80, Mueller Hinton agar, Mueller Hinton Broth, and nutrient dextrose agar were supplied from Merck Chemicals Co. (Germany). Poloxamer® 407 and Miglyol® 812 were obtained from Sigma-Aldrich Company (USA) and Sasol Company (Germany), respectively. Glyceryl palmitostearate (Precirol® ATO-5) was kindly donated by Gattefossé Company (France).
Mokarizadeh M., Kafil H.S., Ghanbarzadeh S., Alizadeh A, & Hamishehkar H. (2017). Improvement of citral antimicrobial activity by incorporation into nanostructured lipid carriers: a potential application in food stuffs as a natural preservative. Research in Pharmaceutical Sciences, 12(5), 409-415.
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2

Melanoma and Fibroblast Cell Lines Evaluation

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Docetaxel powder (DTX) and lidocaine hydrochloride (LDC) were donated by Cristália Prod. Quim. Farm. Ltd.a (Itapira, SP, Brazil). Docetaxel trihydrate 20 mg mL−1 (DTXT-HYD) was kindly provided by Blau Pharmaceutica S.A. (Cotia, SP, Brazil). 18F-fluorodeoxyglucose (18F-[FDG]) was a gift from Cyclobras Ind. Com. Lab. Services Ltda (São Paulo, SP, Brazil). Pluronic F-68 (P68), Myristyl myristate (MM), Miglyol 812® (MG), chitosan (CHT), xanthan (XAN), DMEM medium, fetal bovine serum and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) were supplied by Sigma-Aldrich (St. Louis, MO, USA). Deionized water (18 MΩ) was obtained from an Elga USF Maxima ultra-pure water purifier. Phosphate-buffered saline (PBS), dimethyl sulfoxide and ultrapure water are from Laborclin (Pinhais, PR, Brazil), Vetec (São Paulo, SP, Brazil) and Barnstead™, Thermo Scientific (Thermo Scientific, Waltham, MA, USA), respectively. Murine fibroblasts (NIH-3T3) and murine melanoma (B16-F10) cells were purchased from American type culture collection (ATCC, Manassas, VA, USA). Human melanoma (SK-MEL-103) and human keratinocytes (HaCaT) cell line were purchased from Memorial Sloan Kettering cancer center (New York, NY, USA and CLS cell lines Service GmbH (Heidelberg, Germany), respectively. All other reagents were of analytical grade.
de Moura L.D., Ribeiro L.N., de Carvalho F.V., Rodrigues da Silva G.H., Lima Fernandes P.C., Brunetto S.Q., Ramos C.D., Velloso L.A., de Araújo D.R, & de Paula E. (2021). Docetaxel and Lidocaine Co-Loaded (NLC-in-Hydrogel) Hybrid System Designed for the Treatment of Melanoma. Pharmaceutics, 13(10), 1552.
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3

Formulation and Characterization of Nanoparticles

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Gelucire® 44/14 was donated (Gattefosse, Lyon, France). Miglyol® 812, Tween® 80, Rhodamine 123 (≥85%) were purchased (Sigma-Aldrich, St. Louis, MO, USA). Amicon Ultra® 10 KDa was purchased (Merck, Darmstadt, Germany). SnakeSkinTM Dialysis Tubing of cellulose membrane with a MWCO 10 kDa was purchased (Thermo Fisher Scientific, Rockford, IL, USA). A Milli Q water Ultrapure Simplicity® equipment was used to produce ultrapure water used in all experiments (Merck, Darmstadt, Germany).
Ortiz A.C., Yañez O., Salas-Huenuleo E, & Morales J.O. (2021). Development of a Nanostructured Lipid Carrier (NLC) by a Low-Energy Method, Comparison of Release Kinetics and Molecular Dynamics Simulation. Pharmaceutics, 13(4), 531.
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4

Curcumin-Chitosan Nanoemulsion Development

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Curcumin (from curcuma longa, CAS# 458-37-7, purity 75%, product number C1386, Sigma-Aldrich, Burlington, MA, USA), low-molecular-weight chitosan (CAS# 9012-76-4, 84% deacetylation, 94 cps, product number 448869, Sigma-Aldrich, USA), Miglyol 812 (neutral oil formed by esterification of caprylic fatty acids, CAS# 73398-61-5, 57.2% of C8 fatty acids and 42.4% of C10 fatty acids, Sasol, Houston, TX, USA), Epikuron 145 V (soy lecithin fraction enriched with phosphatidylcholine, CAS 8002-43-5, ≥97% phospholipids, Cargill, Düsseldorf, Germany), acetone, and ethanol were from Merck (Darmstadt, Germany).
Hidalgo A., Bravo D., Soto C., Maturana G., Cordero-Machuca J., Zúñiga-López M.C., Oyarzun-Ampuero F, & Quest A.F. (2023). The Anti-Oxidant Curcumin Solubilized as Oil-in-Water Nanoemulsions or Chitosan Nanocapsules Effectively Reduces Helicobacter pylori Growth, Bacterial Biofilm Formation, Gastric Cell Adhesion and Internalization. Antioxidants, 12(10), 1866.
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5

Formulation and Characterization of Topical Antimicrobial Agents

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Thymol (TH), Tween 20 (TW), poloxamer 188 (P), caprylic/capric triglyceride (Miglyol 812) (CCTG), benzalkonium chloride (BZ), glycerin (GLY), propylene glycol (PG), hydroxypropyl methylcellulose (HPMC), and poloxamer 407 (Pluronic®F127) (PP) were acquired from Sigma-Aldrich (Madrid, Spain). Glyceryl behenate (GBH) (Compritol CG 888 ATO), PEG-8 Caprylic/Capric Glycerides (PCCG), and Transcutol P® (Diethylene glycol monoethyl ether) were provided by Gattefossé (Cedex, France). Carbomer® 934 (Polyacrylic acid, CB) was purchased from Fagron Iberica (Barcelona, Spain). Double-distilled water was filtered through a Millipore filter (Molsheim, France). All other reagents used were of analytical grade.
DMEM (Dulbecco’s Modified Eagle’s medium) was purchased from ThermoFisher, MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) from Sigma-Aldrich (St. Louis, MO, USA) and DMSO (99% dimethyl sulfoxide) from Sigma-Aldrich (Barcelona, Spain).
Mueller–Hinton broth (MHB), Brain Heart Infusion (BHI), Clostridium reinforced medium (CRM), Tryptone Soy Agar (TSA), and Sabouraud Dextrose Agar (SDA) were purchased from Oxoid (Basingstoke, UK). Beren (cosmetic diluent) was acquired from Scharlab (UK).
Folle C., Marqués A.M., Díaz-Garrido N., Carvajal-Vidal P., Sánchez López E., Suñer-Carbó J., Halbaut L., Mallandrich M., Espina M., Badia J., Baldoma L., García M.L, & Calpena A.C. (2024). Gel-Dispersed Nanostructured Lipid Carriers Loading Thymol Designed for Dermal Pathologies. International Journal of Nanomedicine, 19, 1225-1248.
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6

Pomegranate Fruit Compound Extraction

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Pomegranate fruits (cv. Wonderful) were collected at the ripening stage (April 2017) from a commercial farm located in Vallenar (28°SL), in the Atacama Region of Chile. Fruit samples were stored at 4 °C and processed within 24 h of collection. Orange oil (density 843 kg/m3 at 25 °C), castor oil (density 836 kg/m3 at 25 °C), Miglyol® 812 (density 945 kg/m3 at 20 °C), sunflower oil (density 919.3 kg/m3 at 25 °C) and soybean oil (density 850 kg/m3 at 25 °C) were supplied by Sigma–Aldrich Co. (Darmstadt, Germany). Polyglycerol polyricinoleate (PGPR, C21H42O6) was purchased from Brenntag AG (Essen, Germany) and used as a lipophilic emulsifier. Tween 80 (polyoxyethylene sorbitan monooleate), supplied by Sigma–Aldrich Co. (Germany), was used as hydrophilic emulsifier. HPLC-grade acetonitrile, methanol and chloroform were obtained from Sigma–Aldrich (St. Louis, MO, USA).
Sanhueza L., García P., Giménez B., Benito J.M., Matos M, & Gutiérrez G. (2022). Encapsulation of Pomegranate Peel Extract (Punica granatum L.) by Double Emulsions: Effect of the Encapsulation Method and Oil Phase. Foods, 11(3), 310.
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