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Sonata 1.5 tesla scanner

Manufactured by Siemens
Sourced in Germany

The Sonata 1.5 Tesla scanner is a magnetic resonance imaging (MRI) system designed by Siemens. It has a static magnetic field strength of 1.5 Tesla, which is a commonly used field strength for clinical MRI scans. The Sonata 1.5 Tesla scanner is capable of producing high-quality images of the body's internal structures and is used by healthcare professionals for diagnostic purposes.

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4 protocols using sonata 1.5 tesla scanner

1

High-Resolution Brain MRI Acquisition Protocol

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High-resolution MRI scans were obtained using a Siemens Sonata 1.5 Tesla scanner (Siemens AG, Munich, Germany). Head positioning was standardized using canthomeatal landmarks. Brain scans were acquired using a 3D MP-RAGE sequence (repetition time, 24 ms; echo time, 2.96 ms; 45° flip angle; 256 × 192 matrix; field of view, 30 cm; 2 excitations, slice thickness 1.2 mm; 124 contiguous slices encoded for sagittal slice reconstruction with voxel dimensions of 1.17 × 1.17 × 1.2 mm).
During scan acquisition, we closely monitored data from each sequence in real time as images were reconstructed and displayed on the scanner console. Any visible motion triggered a repeat of the sequence. Image quality within individual pulse sequences was assessed in more detail during preprocessing within 48 h of the scan, as described below. Every effort was made to bring back for repeat scanning, with the relevant pulse sequences, any participants who had images containing a motion artifact. Additional quality control for anatomical images included ratings of image sharpness, ringing, contrast-to-noise ratio of subcortical nuclei, and gray/white matter interface.
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2

Comprehensive Cytogenetic Analyses of Rare Condition

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Standard cytogenetic protocols were used to culture amniocytes, peripheral blood lymphocytes and skin fibroblasts and to perform conventional G‐banded chromosome analysis. Fluorescence in situ hybridization (FISH) was performed using subtelomeric probes for chromosome 12p (RP11‐283I3) and 12q (RP11‐46H11). Probes were labeled with SpectrumOrange and SpectrumGreen (Abbott Molecular, USA) and FISH signals were examined using the Applied Imaging CytoVision image capture system (Leica Biosystems, Germany). DNA was extracted from peripheral blood and skin fibroblasts from proband two using standard methods. Chromosomal microarray was performed using an Infinium® HumanCytoSNP‐12 BeadChip assay according to manufacturer's instructions (Illumina, San Diego, CA, USA) and data were analyzed using KaryoStudio software. Magnetic Resonance Imaging (MRI) data were generated using a Siemens Sonata 1.5 tesla scanner. Parents of both probands provided informed consent for this study.
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3

High-Resolution Anatomical Brain Imaging

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We obtained 1.17×1.17×1.2mm3 resolution anatomical MRI scans on a Siemens Sonata 1.5 Tesla scanner (Siemens AG) using a 3D-MPRAGE sequence: Repetition Time(TR)=24 msec; Echo Time(TE)=2.96 msec; Flip Angle(FA)=45°; Matrix size = 256 × 192; Field of View(FOV)=30 cm; Phase Field of View=100%; Number of Excitations(NEX)=2, Slice Thickness=1.2mm; and 124 contiguous slices encoded for sagittal slice reconstruction.
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4

Standardized MRI Acquisition and Analysis

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MRI scans were obtained using a Siemens Sonata 1.5 Tesla scanner (Siemens, AG, Erlangen, Germany). Head positioning was standardized using canthomeatal landmarks. Anatomical images were acquired using a 3D MP-RAGE sequence (repetition time, 24 msec; echo time, 2.96 msec; 45° flip angle; 256 × 192 matrix; field of view, 30 cm; 2 excitations, slice thickness 1.2 mm; 124 contiguous slices encoded for sagittal slice reconstruction with voxel dimensions of 1.17 mm × 1.17 mm × 1.2 mm).
We corrected large-scale variations in image intensity using a validated algorithm developed at the Montreal Neurological Institute (Sled et al., 1998 (link)). We removed extracerebral tissues using an automated tool for extracting the brain (Shattuck and Leahy, 2002 (link)). Connecting dura was then removed manually on each slice in the sagittal view and checked in the orthogonal views. The brainstem was transected at the pontomedullary junction. We measured whole brain volume (WBV) for use as a covariate to control for global scaling effects in statistical analyses of conventional volumes. This measure included not only gray and white matter but also cerebrospinal fluid within the ventricles and cortical sulci to ensure the exclusion of any possible confound of age-related effects of tissue atrophy with this general measure of body scaling (Skullerud, 1985 (link)).
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