B6.129s tnfrsf1atm1imxtnfrsf1btm1imx j

C57BL/6 wild-type control mice were obtained from the UT Southwestern Mouse Breeding Core Facility. IL-1β^−/− mice were generated by David Chaplin, UA at Birmingham and provided to us by Fayyaz S. Sutterwala at Cedars Sinai. Rip3^−/− and Rip3^−/−Casp8^−/− mice were provided by Andrew Oberst at the University of Washington. ASC KO mice were a gift from Genentech. Gsdmd^−/− mice were provided by Jonathan Kagan at Boston Children’s Hospital. Caspase-1 KO were provided by Russell Vance at University of California, Berkeley. B6.MRL-Fas^lpr/J (lpr), B6.129S-Tnf^tm1Gkl/J (Tnfa^−/−), B6.129S-Tnfrsf1a^tm1ImxTnfrsf1b^tm1Imx/J (Tnfrsf1a/b^−/−), Rag1^tm1Mom, Casp1/11^null, 2D2 TCR transgenic mice and Zbtb46^gfpwere obtained from Jackson Laboratories. All mice were bred and housed in a specific pathogen-free facility at UT Southwestern Medical Center and Cincinnati Children’s Hospital Medical Center. For isolation of steady state CD4 memory T cells, mice were housed in a conventional facility for 2–4 weeks before tissue isolation. All mouse experiments were done as per protocols approved by Institutional Animal Care and Use Committee (IACUC) at UT Southwestern Medical Center and Cincinnati Children’s Hospital Medical Center.