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Cann cg foxn1nu cr

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CAnN.Cg-Foxn1nu/Cr is a mouse model maintained by Jackson ImmunoResearch. It is a nude mouse strain that is characterized by the absence of a functional thymus gland, leading to a lack of T cells. This model is commonly used in immunology research.

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Lab products found in correlation

P4543, by Merck Group (2 mentions) C0621, by Merck Group (2 mentions) Ci 994, by Merck Group (2 mentions)

2 protocols using cann cg foxn1nu cr

1

Xenograft Mouse Model for Cancer

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The animal protocol for this study was approved by the NCI/CCR Animal Care and Use Committee (ASP SOP-001). QGP-1 or BON-1 cells (5 × 106 cells) were injected subcutaneously into both flanks of five- to seven-week-old athymic nude male mice CAnN.Cg-Foxn1nu/Cr, (The Jackson Laboratory). The resulting tumors were further subcutaneously implanted, to create homogenous tumors. Only tumors from generations 1 to 3 were utilized. Tumor size was monitored using a Vernier caliper, with tumor initiation size ranging from 5 to 7 mm. The mice were euthanized if they exhibited impeded movement, if there were signs of breathing difficulty or tumors exceeded 2 cm in diameter at any point in the study. Mice were randomly grouped into control and treatment groups and then treated via intraperitoneal daily injections with either VPA (300 mg/kg; P4543; Sigma-Aldrich) dissolved in water, CI-994 (5 mg, 7.5 mg, and 10 mg/kg; C0621; Sigma-Aldrich) dissolved in 0.1% DMSO, or 0.1% DMSO as control group. All interventions were done during the light cycle, and mice were not fasted before assessments.
Sharma R., Earla B., Baidoo K.E., Zeiger M.A., Madigan J.P., Escorcia F.E, & Sadowski S.M. (2023). Upregulation of Somatostatin Receptor Type 2 Improves 177Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model. Molecular Cancer Therapeutics, 22(9), 1052-1062.
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2

Xenograft Mouse Model for Cancer

Check if the same lab product or an alternative is used in the 5 most similar protocols
The animal protocol for this study was approved by the NCI/CCR Animal Care and Use Committee (ASP SOP-001). QGP-1 or BON-1 cells (5×106 cells) were injected subcutaneously into both flanks of five- to seven-week-old athymic nude male mice CAnN.Cg-Foxn1nu/Cr, (Jackson Laboratory). The resulting tumors were further subcutaneously implanted, to create homogenous tumors. Only tumors from generations 1 to 3 were utilized. Tumor size was monitored using a Vernier caliper, with tumor initiation size ranging from 5 to 7 mm. The mice were euthanized if they exhibited impeded movement, if there were signs of breathing difficulty or tumors exceeded 2 cm in diameter at any point in the study. Mice were randomly grouped into control and treatment groups and then treated via intraperitoneal (i.p.) daily injections with either VPA (300 mg/kg; P4543; Sigma Aldrich) dissolved in water, CI-994 (5mg, 7.5mg and 10mg/kg; C0621; Sigma Aldrich) dissolved in 0.1% DMSO, or 0.1% DMSO as control group. All interventions were done during the light cycle, and mice were not fasted before assessments.
Sharma R., Earla B., Baidoo K.E., Zeiger M.A., Madigan J.P., Escorcia F.E, & Sadowski S.M. (2023). Upregulation of Somatostatin Receptor Type 2 Improves 177Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model. Molecular Cancer Therapeutics, 22(9), 1052-1062.
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