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Ku55933

Manufactured by Cayman Chemical
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KU55933 is a small molecule inhibitor that targets and inhibits the activity of the phosphoinositide 3-kinase-related kinase (PIKK) family, which includes ATM, ATR, DNA-PK, and mTOR. This product is intended for research use only.

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Lab products found in correlation

Doxorubicin, by Bio-Techne (1 mentions) Jnk in 8, by Selleck Chemicals (1 mentions) Bay 11 7082, by Cayman Chemical (1 mentions) Ara c, by Selleck Chemicals (1 mentions) Ly2228820, by Selleck Chemicals (1 mentions) D luciferin, by Cayman Chemical (1 mentions)

3 protocols using ku55933

1

Ionizing Radiation-Induced DNA Damage

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Indicated cells were pre-treated with 10μM KU55933 (Cayman Chemical Company) for 2 hours before being dosed with 2GYs ionizing radiation (IR). Protein was harvested from plates as described above and analyzed via immunoblotting.
Pearson S.J., Sarkar T.R., McQueen C.M., Elswood J., Schmitt E.E., Wall S.W., Scribner K.C., Wyatt G., Barhoumi R., Behbod F., Rijnkels M, & Porter W.W. (2018). ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition. Oncogene, 38(14), 2611-2626.
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2

Pharmacological Agents for Cell Studies

Cited 3 times
Check if the same lab product or an alternative is used in the 5 most similar protocols
Pirfenidone (10 to 300 μg/ml [71 (link), 116 –118 (link)]) was obtained from Chemietek. AraC (1 to 10 μM [119 (link), 120 ]), LY2228820 (0.03 to 2 μM [68 (link), 69 (link), 121 (link), 122 (link)]), BIRB796 (BIRB, 5 μM [70 (link), 123 (link)–126 (link)]), and JNK-IN-8 (1 μM [127 (link)] were from Selleckchem. KU55933 (10 μM [128 (link)], tested but was toxic for the cells tested), BAY 11-7082 (10 μM [78 (link)]), and D-luciferin were from Cayman Chemical and doxorubicin (10 to 500 nM [129 (link)]) was from Tocris Bioscience.
Lee S., Micalizzi D., Truesdell S.S., Bukhari S.I., Boukhali M., Lombardi-Story J., Kato Y., Choo M.K., Dey-Guha I., Ji F., Nicholson B.T., Myers D.T., Lee D., Mazzola M.A., Raheja R., Langenbucher A., Haradhvala N.J., Lawrence M.S., Gandhi R., Tiedje C., Diaz-Muñoz M.D., Sweetser D.A., Sadreyev R., Sykes D., Haas W., Haber D.A., Maheswaran S, & Vasudevan S. (2020). A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells. Genome Biology, 21, 33.
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3

Ionizing Radiation-Induced DNA Damage

Check if the same lab product or an alternative is used in the 5 most similar protocols
Indicated cells were pre-treated with 10μM KU55933 (Cayman Chemical Company) for 2 hours before being dosed with 2GYs ionizing radiation (IR). Protein was harvested from plates as described above and analyzed via immunoblotting.
Pearson S.J., Sarkar T.R., McQueen C.M., Elswood J., Schmitt E.E., Wall S.W., Scribner K.C., Wyatt G., Barhoumi R., Behbod F., Rijnkels M, & Porter W.W. (2018). ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition. Oncogene, 38(14), 2611-2626.
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