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4.7 t magnet

Manufactured by Agilent Technologies
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The 4.7-T magnet is a high-field superconducting magnet designed for use in various laboratory applications. It provides a strong and stable magnetic field of 4.7 Tesla, which is suitable for a range of scientific research and analytical techniques, such as nuclear magnetic resonance (NMR) spectroscopy.

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Lab products found in correlation

9.4 t magnet, by Agilent Technologies (1 mentions) Unity inova spectrometer, by Agilent Technologies (1 mentions)

Close spelling variants of this product

Horizontal bore 4.7-T magnet

3 protocols using 4.7 t magnet

1

Dynamic Spin Preparation CEST Imaging

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In the DSP-CEST, after the signal preparation based on a rectangular RF saturation pulse with a duration of 5 seconds, single-shot spin-echo echo planar imaging (SE-EPI) is used for a 2D image readout with parameters: matrix size = 64 × 64, field of view = 30 × 30 mm2. DSP-CEST Z-spectra (B1 = 0.5 μT and 1 μT) were acquired with the frequency offsets from −2000 Hz to −1250 Hz with a step size of 250 Hz (−10 ppm to −6.25 ppm with a step size of 1.25 ppm at 4.7 T), −1000 Hz to 1000 Hz with a step size of 25 Hz (−5 ppm to 5 ppm with a step size of 0.125 ppm at 4.7 T), and 1250 Hz to 2000 Hz with a step size of 250 Hz (6.25 ppm to 10 ppm with a step size of 1.25 ppm at 4.7 T). Control images were acquired with the frequency offset of 100,000 Hz (500ppm at 4.7T). R1w and MT pool size ratio were obtained using a selective inversion recovery (SIR) method with inversion times of 4, 5, 6, 8, 10, 12, 15, 20, 50, 200, 500, 800, 1000, 2000, 4000, and 6000 ms (57 (link)). All measurements were performed on a Varian 4.7-T magnet with a 38-mm receive coil.
Terry R.W., Kwee L., Levine J.F, & Labow M.A. (1993). Cytokine induction of an alternatively spliced murine vascular cell adhesion molecule (VCAM) mRNA encoding a glycosylphosphatidylinositol-anchored VCAM protein.. Proceedings of the National Academy of Sciences of the United States of America, 90(13), 5919-5923.
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2

CW-CEST Imaging and Quantification

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A continuous wave (CW)-CEST sequence with a 5-second hard saturation pulse followed by single-shot spin-echo echo planar imaging (SE-EPI) acquisitions with a TR of 7 second was used on animal imaging. Images were acquired with matrix size 64 × 64, field of view 30 mm × 30 mm, 2 mm slice thickness, and one acquisition. A non-imaging CW-CEST sequence with free induction decay (FID) readout and 8-second hard saturation pulse and TR of 10 second was used for phantom imaging. Z-spectra were acquired with RF offsets (Δω) from −10 ppm to 10 ppm. Control images were acquired with RF offsets of 250 ppm. R1w and MT pool size ratio were obtained using a selective inversion recovery quantitative MT method (33 (link)). All in vivo and phantom imaging were performed at 37°C with saturation power of 0.5 μT. Experiments on all animals and phantoms were performed on a Varian 4.7-T magnet, and the reconstituted phospholipids were performed on a Varian 9.4-T magnet.
McCune S.L., Reilly M.P., Chomo M.J., Asakura T, & Townes T.M. (1994). Recombinant human hemoglobins designed for gene therapy of sickle cell disease.. Proceedings of the National Academy of Sciences of the United States of America, 91(21), 9852-9856.
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3

Cardiac MRI Imaging Protocol

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MR imaging was performed using a Varian 4.7T magnet with a UnityInova spectrometer. A birdcage volume coil (72 mm inner diameter) was used for both transmitting and receiving. An animal monitoring system (Small Animal Instruments Inc., Stony Brook, NY) enabled image acquisition to be gated to ECG and respiration. Throughout imaging, the core body temperature of the animal was maintained at 35–38°C by directing a regulated stream of warm air over the animal, and both heart rate and body temperature were recorded.
Cine MR images at 3 long‐axis (angular spacing = 60°) and 6 short‐axis slices (spacing = 0.6 mm–1.0 mm) were acquired to ensure full coverage of the LV. Each slice was imaged at 18 evenly spaced time‐points through the cardiac cycle. T1‐weighted gradient‐echo cine acquisitions used the following parameters: repetition time, TR = 2 ×  R‐R interval, ~ 280 ms ‐ 360 msec; echo time, TE = 2.2 msec; cardiac phases = 20; flip angle = 20°; slice thickness = 2 mm; averages = 2, field of view = 60 mm × 60 mm; matrix = 128 pixels × 128 pixels; gap between slices = 0.6 mm–1.0 mm according to the size of the heart.
Wilson A.J., Wang V.Y., Sands G.B., Young A.A., Nash M.P, & LeGrice I.J. (2017). Increased cardiac work provides a link between systemic hypertension and heart failure. Physiological Reports, 5(1), e13104.
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