Amitriptyline

Manufactured by Selleck Chemicals

Sourced in Germany

Amitriptyline is a solid chemical compound used in the manufacture of various pharmaceutical products. It serves as a key ingredient in the production of medications. The primary function of amitriptyline is to provide a core chemical structure for further formulation and development of drugs.

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Lab products found in correlation

Melphalan, by Merck Group (1 mentions) Gw4869, by Merck Group (1 mentions) Bortezomib, by Selleck Chemicals (1 mentions) Clozapine, by Merck Group (1 mentions) Agomelatine, by Selleck Chemicals (1 mentions) Ketanserin, by Selleck Chemicals (1 mentions) Sb258585, by Merck Group (1 mentions) Sb271046, by Selleck Chemicals (1 mentions) Sb742457, by Selleck Chemicals (1 mentions) Asenapine, by Selleck Chemicals (1 mentions)

2 protocols using amitriptyline

Solubilization of Pharmacological Compounds

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Bortezomib and amitriptyline were purchased from Selleckchem (Munich, Germany), GW4869 and melphalan were purchased from Sigma-Aldrich (St-Louis, MO, USA). Bortezomib and amitriptyline were dissolved in dimethylsulfoxide while melphalan was dissolved in ethanol with a few drops of HCl, all according to the manufacturer’s instructions. GW4869 was also dissolved in DMSO, resuspended, and vortexed, after which the solution was incubated at 37 °C for 15 min to reach maximum solubility.

Faict S., Oudaert I., D’Auria L., Dehairs J., Maes K., Vlummens P., De Veirman K., De Bruyne E., Fostier K., Vande Broek I., Schots R., Vanderkerken K., Swinnen J.V, & Menu E. (2019). The Transfer of Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma. Cancers, 11(12), 1823.

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Diverse Pharmacological Compounds for Research

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Asenapine (S1283), blonanserin (S2112), droperidol (S4096), ziprasidone (S1444), iloperidone (S1483), amitriptyline (S3183), SB271046 (S2856), ketanserin (S2232), agomelatine (S1243), levosulpiride (S2104), SB742457 (S2894) and chlorprothixene (S1771) were purchased from Selleck. 3-methylade (5142-23-4) was purchased from Energy Chemical. Clozapine (C6305), SB258585 (S1194) and bafiloycinA1 (B1793) were purchased from Sigma. Sertindole (106516-24-9) was purchased from UHN.

Zhang W., Zhang C., Liu F., Mao Y., Xu W., Fan T., Sun Q., He S., Chen Y., Guo W., Tan Y, & Jiang Y. (2018). Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases. Scientific Reports, 8, 15753.

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