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Advantage v2 kit

Manufactured by Quanterix
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The Advantage v2 kit is a laboratory equipment product manufactured by Quanterix. It is designed to perform sensitive and precise protein measurements. The core function of the Advantage v2 kit is to enable researchers to analyze and quantify specific proteins in biological samples.

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Lab products found in correlation

Sr x analyzer, by Quanterix (1 mentions) Neurology 2 plex b, by Quanterix (1 mentions)

Close spelling variants of this product

Simoa NF-light V2 Advantage Kit PTau-181 V2 Advantage Kit Ptau181 Advantage V2 Assay Kit P-tau181 Advantage V2 kit Simoa® pTau-181 V2 Advantage Kit

2 protocols using advantage v2 kit

1

Plasma Biomarkers for Neurological Diseases

Cited 1 time
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Duplicate blood samples were analyzed in-house (Quanterix SRX analyzer), blinded to all clinical and demographic data, using single molecule array (Simoa) technology for p-tau181 (Quanterix Advantage v2 kit), GFAP, and NfL (Quanterix Neurology 2-Plex B). Our group previously reported separate plasma NfL data in a smaller sample of the 1FLADRC.19 (link) NfL data are reported here in a larger cohort with different study aims and using a different Quanterix Simoa assay. Samples with coefficients of variation >20% were excluded (p-tau181: 10.8% of sample, GFAP: 7.4%, NfL: 6.3%). Additional sample collection and processing details are provided in Supplementary Methods.
Asken B.M., Wang W., McFarland K., Arias F., Fiala J., Velez‐Uribe I., Mayrand R.P., Sawada L.O., Freytes C., Adeyosoye M., Marsiske M., Rosselli M., Barker W.W., Curiel Cid R., Loewenstein D.A., DeKosky S.T., Armstrong M.J., Smith G.E., Adjouadi M., Vaillancourt D.E, & Duara R. (2023). Plasma Alzheimer's biomarkers and brain amyloid in Hispanic and non‐Hispanic older adults. Alzheimer's & Dementia, 20(1), 437-446.
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2

Quantification of NfL in CSF and Plasma

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NfL levels were measured in CSF and plasma using a Quanterix Simoa digital immunoassay platform (NF-Light kit, 103186, and NF-Light Advantage V2 kit, 104073). The minimum required dilutions for CSF and blood analysis were 100-fold and four-fold, respectively. All calibrators, controls and buffers were prepared in accordance with the manufacturer’s instructions. In addition to controls provided by the manufacturer, buffer and matrix QCs were included in each run.
Sevigny J., Uspenskaya O., Heckman L.D., Wong L.C., Hatch D.A., Tewari A., Vandenberghe R., Irwin D.J., Saracino D., Le Ber I., Ahmed R., Rohrer J.D., Boxer A.L., Boland S., Sheehan P., Brandes A., Burstein S.R., Shykind B.M., Kamalakaran S., Daniels C.W., David Litwack E., Mahoney E., Velaga J., McNamara I., Sondergaard P., Sajjad S.A., Kobayashi Y.M., Abeliovich A, & Hefti F. (2024). Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results. Nature Medicine, 30(5), 1406-1415.
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