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Magnetom 7t scanner

Manufactured by Siemens
Sourced in Germany

The Magnetom 7T is a magnetic resonance imaging (MRI) system produced by Siemens. It is a high-field MRI scanner that operates at a magnetic field strength of 7 Tesla, which is significantly stronger than the magnetic field strength of conventional MRI systems. The Magnetom 7T is designed for advanced research applications and provides high-resolution imaging capabilities for detailed anatomical and functional studies.

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43 protocols using magnetom 7t scanner

1

High-resolution 7T Diffusion Weighted Imaging

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We first re-analyzed the dataset from a whole body 7 T MAGNETOM scanner (Siemens Healthcare) used and described already in Becker et al. (2012) (link). The scanner was equipped with gradients with a peak amplitude of 70mT/m and a maximum slew rate of 200 T/m/s (SC72, Siemens Healthcare, Erlangen, Germany). Diffusion weighting gradients were applied along 60 different directions at a b-value of 1000 s/mm2. 7 interspersed non-diffusion weighted S0 images were acquired. The scan was repeated 4 times. An optimized monopolar Stejskal–Tanner sequence according to Morelli et al. (2010) (link) together with the ZOOPPA approach described in Heidemann et al. (2012) (link) has been used for the scan. The experiment was performed using a single channel transmit, 24-channel receive phased array head coil (Nova Medical, Wilmington, MA, USA). 91 slices with 10% overlap were acquired at a field-of-view (FoV) of 143 × 147 mm2 resulting in an isotropic high resolution of 800 μm. Further imaging protocol parameters were: TR 14.1 s, TE 65 ms, BW 1132Hz/pixel, ZOOPPA acceleration factor of 4.6. A healthy adult volunteer was scanned four times using this protocol in one session after obtaining written informed consent in accordance with the ethical approval from the University of Leipzig. Total acquisition time was 65 min. We used the raw diffusion weighted data.
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2

High-Resolution Functional Imaging at 7T

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Participants were scanned on a research-dedicated Siemens 7T Magnetom scanner in the Clinical Research Center on the National Institutes of Health Campus (Bethesda, MD). Partial T2*-weighted functional image volumes were acquired using a gradient echo planar imaging (EPI) sequence with a 32-channel head coil (47 slices; 1.6 × 1.6×1.6 mm; 10% interslice gap; TR, 2 s; TE, 27 ms; matrix size, 126 × 126; FOV, 192 mm). Oblique slices were oriented approximately parallel to the base of the temporal lobe and were positioned such that they covered the occipital, temporal, and parietal cortices, and as much as possible of frontal cortex. After the functional imaging runs, standard MPRAGE (magnetization-prepared rapid-acquisition gradient echo) and corresponding GE-PD (gradient echo–proton density) images were acquired, and the MPRAGE images were then normalized by the GE-PD images for use as a high-resolution anatomical image for the following fMRI data analysis (Van de Moortele et al., 2009 (link)).
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3

High-Resolution 7T MRSI Protocol

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We imaged with a concentric ring trajectory-based MRSI sequence on a 7 T Magnetom scanner (Siemens Healthcare, Erlangen, Germany) with a 32-channel receive array coil (Nova Medical, Wilmington, MA, USA), featuring a 64 × 64 × 39 matrix with 3.4 mm3 isotropic resolution [15 (link)]. The acquisition took 15 min with 450 ms TR and 1.3 ms acquisition delay, covering a manually placed 220 × 220 × 133 mm3 field of view (FOV) [10 (link), 15 (link)]. More details are found in Supplementary Table 2, which reports MRS parameters in the MRSinMRS standard [16 (link)]. We additionally obtained 7 T 0.8 mm3 isotropic T1-weighted MP2RAGE in 8:02 min and 0.8 mm3 isotropic fluid-attenuated inversion recovery (FLAIR) in 8:10 min.
Clinical 3 T MRI consisted of FLAIR, T2-weighted MRI, and pre- and post-contrast T1-weighted MRI (Gadoteridol, 0.1 mmol/kg).
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4

MRS Acquisition on 7T Scanner

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All MRS measurements were performed on a 7 T Magnetom scanner (Siemens Healthineers, Erlangen, Germany) with a 28‐channel knee coil (Quality Electrodynamics, Mayfield Village, OH).
The spectroscopic voxel was positioned according to T1‐weighted scout images. The frequency was adjusted on the CH2 signal at 1.3 ppm and the homogeneity of the B0 field was first improved with automatic B0 shimming calculated from gradient echo images, then manually adjusted in an interactive mode. The reference voltage for RF pulses was automatically calibrated by the scanner. A frequency offset of –0.3 ppm was used for all measurements.
The PRESS sequence was equipped with the same Hermite pulses and durations as in the simulation. The signal was acquired with 2048 complex points and the receiver bandwidth was set to 3000 Hz.
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5

Multimodal Neuroimaging in Anesthetized Sheep

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Anatomical MR images and MRS data were collected a 3 time points throughout the study on a 7T MAGNETOM scanner (Siemens Healthcare, Erlangen, Germany). A 32-channel head coil (Nova Medical, Boston, MA) was used for all scans. The imaging protocol included 3D T1-weighted sequence and 2D T2-weighted TSE sequence. Single voxel spectroscopy was acquired using the stimulated echo acquisition mode with variable pulse power and optimized relaxation delays water suppression, TE/TR= 4.6/10,000ms and 32 averages. In all animals, a 10mm· 10mm· 17mm voxel was placed in the striatothalamic region that was well defined on the high-resolution anatomical images. Sheep were premedicated with buprenorphine (0.02 mg/kg), acepromazine (0.05 mg/kg), and glycopyrrolate (0.01 mg/kg) intramuscularly. Sheep were anesthetized using midazolam (0.3 mg/kg) and ketamine (10 mg/kg) intravenously, intubated, and anesthesia was maintained using isoflurane gas during the procedure. Sheep were imaged in dorsal recumbency.
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6

High-Resolution 7T fMRI of Somatosensory Cortex

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All MRI measurements were acquired using a Siemens 7 T Magnetom scanner with a 32‐channel head coil. Task fMRI data were acquired using a multiband GE echo planar imaging (EPI) sequence with an acceleration factor of 2 (Moeller et al., 2010 (link); Ugurbil et al., 2013 (link)). A limited field‐of‐view (FOV) was used consisting of 56 slices each 1 mm thick over the primary somatosensory cortex with a 192 × 192 mm in‐plane FOV (TR: 2000 ms, TE: 25 ms, FA: 85°, GRAPPA factor: 3). This resulted in spatial resolution of 1 mm isotropic. A whole brain anatomical T1‐weighted (MPRAGE) image was also collected with a 1 mm isotropic spatial resolution (FOV: 192 × 192 × 176, TR: 2200 ms, TE: 2.82 ms, FA: 7°, TI: 1050 ms, GRAPPA factor: 4).
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7

High-resolution 7T resting-state fMRI

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MR images were acquired using a 7 T Magnetom scanner (Siemens Healthcare, Erlangen, Germany). MPRAGE images were acquired first using the following imaging parameters: TR/TE/TI = 2200/2.79/1050 ms, flip angle = 7°, partition thickness = 0.94 mm, image matrix = 256 × 208, 192 partitions, and FOV = 24.0 cm × 19.5 cm. Subsequently, two 6-min resting-state scans were acquired using the blipped Partition-encoded Simultaneous Multi-Slab (bPRISM) sequence. The details of the bPRISM sequence can be found in the Supplementary Information. The participants were instructed to remain awake with eye opened during the resting-state scans. The spatial resolution was 0.94 mm isotropic using the following imaging parameters: FOV = 169 × 112.7 × 164.5 (R-L × H-F × A-P) mm3; SMS factor = 7; TE = 23 ms; TR per slab volume = 400 ms; effective TR = 2 s; and number of repetitions 180.
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8

Multi-site T1-weighted MRI Protocols

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In IMAGEN, T1-weighted images were collected using 3-T scanners and the ADNI protocols [33 ]. UKB used a Siemens Skyra 3-T scanner with a 3D MPRAGE protocol (Additional file 1: Method S2). All data were preprocessed in SPM8 using the VBM8 toolbox, including the segmentation, normalization, modulation, and smoothing. The resulting voxel size was 1.5 × 1.5 × 1.5 mm3 (Additional file 1: Method S1). HCP used a Siemens 7-T MAGNETOM scanner with a high spatial resolution of 1.05 mm isotropic (Additional file 1: Method S3) [49 (link)].
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9

High-Resolution 7T fMRI Protocol

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Data were acquired using a Siemens 7 T Magnetom scanner in the Clinical Research Centre on the National Institutes of Health campus (Bethesda, MD). Partial EPI volumes of the occipital and temporal cortices were acquired using a 32-channel head coil (42 slices; 1.2 × 1.2 × 1.2 mm; 10% interslice gap; TR, 2 s; TE, 27 ms; matrix size, 170 × 170; FOV, 192 mm). Anatomical T1 weighted volumes were acquired before the experimental runs. Standard MPRAGE (Magnetization-Prepared Rapid-Acquisition Gradient Echo) and corresponding GE-PD (Gradient Echo–Proton Density) images were collected and the MPRAGE images were then normalized by the GE-PD images, for use as high-resolution anatomical data for the fMRI data analysis.
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10

High-Resolution Retinotopic Mapping at 7T

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For six participants, retinotopy was measured in a separate session, at 7T, using nonperiodic traveling bar stimuli and analyzed using the population receptive field (pRF) method [100 (link)]. Bars were 3 deg wide and traversed the field of view in sweeps lasting 24 s. Eight different bar configurations (four orientations and two traversal directions) were presented. Data were acquired on a research-dedicated Siemens 7T Magnetom scanner using a 32-channel head coil. Functional imaging was conducted with 54 slices oriented perpendicular to the calcarine sulcus covering the posterior half of the brain (TR: 1,500 ms; TE: 23 ms; FA: 55°; voxel size: 1.2 × 1.2 × 1.2 mm with 10% gap between slices, respectively; grid size: 160 × 160 voxels. Multiband factor 2, GRAPPA/iPAT factor 3). The pRF of each voxel was estimated using standard fitting procedures [100 (link)], implemented in Matlab using mrTools. A map of the eccentricity of the center of each voxel’s fitted pRF was used solely for visual comparison to maps of task-related activity.
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